Sample pretreatment on microfabricated devices

Lichtenberg, Jan; Rooij, N. F. de; Verpoorte, Elisabeth

doi:10.1016/s0039-9140(01)00593-8

Cited by 183 publications

(126 citation statements)

References 91 publications

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“…The other field in this area is design of a microscale analytical systems with electrochemical detections, where in appropriate microfluidic system flow analysis or capillary electrophoresis can be carried out [118], including various sample pretreatment operations [119]. Microfluidic capillary electrophoresis systems will be discussed separately below.…”

Section: Miniaturization In Flow Electroanalysismentioning

confidence: 99%

Electroanalytical Flow Measurements–Recent Advances

2003

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As general trends in current development of chemical analysis, including electroanalysis, one can indicate a search for methods fast and multianalyte, for miniaturized measuring devices, mechanization and automation of analytical processes. In all these trends a significant role is played by measurements in flow conditions. The major advantage of flow electroanalysis is a possibility of utilizing a kinetic discrimination in potentiometric measurements and enhancement of mass transport in voltammetric techniques. Flow injection techniques provide shortening of time of a single analytical determination due to reproducible use of transient signal from the detector without need of obtaining a steady-state equilibrium signal. Electrochemical detection in HPLC gives often improved selectivity and detection limit for electroactive solutes, whereas in capillary electrophoresis it allows a convenient design of portable, integrated chips for field application. This review presents state-of-the -art of flow electroanalysis based on 226 cited literature references

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Section: Miniaturization In Flow Electroanalysismentioning

confidence: 99%

Electroanalytical Flow Measurements–Recent Advances

2003

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“…Furthermore, microchips can be used as a microreactor in organic synthesis, and high reaction yields compared to the conventional procedure have been reported. [7][8][9] For example, the enzyme reaction of horseradish peroxidase in a microchip was compared to that in a cuvette by using thermallens microscopy, and an almost twofold higher reaction rate than the bulk scale was reported. It is considered that such advantages of mTAS arise from the unique mass-transfer mechanism in microchannels.…”

Section: Introductionmentioning

confidence: 99%

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

2008

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The diffusion phenomena, dispersion and mixing processes of the sample solute (Basic Blue 3 dye and KMnO4 aqueous solutions) were directly observed in laminar flow in glass microchannels. Quasi steady-state UV-visible absorption spectrometry was carried out using CCD camera images of the colored sample dispersion and mixing processes, and the absorbance change (DAbs) was discussed based on the dimensionless parameter, t which represents the flow time renormalized to the diffusion coefficient and the channel cross section. It was found that DAbs showed almost the same t dependence, even though the solutions and the microchannel sizes differed in laminar flow, if the microchannel fabrication method was the same. On the basis of this fundamental result, the total microchannel length required for the reaction of 2,3-diaminonaphthalene (DAN) and NO2 -at a flow rate of 2 mL min -1 was calculated, and the obtained value (~100 mm) showed very good agreement with our previous microchip research. It was concluded that both results were useful for designing the microchannel width, depth and length to control the chemical reaction time in recent microfluidic systems.

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“…There are numerous examples of microanalytical systems that cover many applications and processes, such as pumping, mixing and diluting, precolumn and postcolumn reactors, injectors, filters, preconcentrators, cell sorters, detectors, and so on. [5][6][7][8] Considering that in most situations the sample pretreatment is crucial for the success of the analysis, 9 future developments in this field should address not only the analytical steps but also the connection with the macroscopic world.…”

Section: Introductionmentioning

confidence: 99%

Retention of copper(II) metal ions in a silicon-glass microfluidic device

Silva

Lago

Furlan³

2007

J. Braz. Chem. Soc.

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Neste trabalho é descrita a construção de um microssistema em silício para retenção de íons cobre(II). Processo fotolitográfico convencional foi empregado para transferir o padrão de microcanais para o substrato de silício. Utilizando corrosão por íons reativos (RIE) com plasma de SF 6 , foram produzidos canais de 50 μm de largura e 10 μm de profundidade. Os canais foram selados com vidro de borossilicato utilizando-se a técnica de soldagem anódica. Para promover a retenção dos íons cobre(II), a superfície dos canais foi modificada através de reação de silanização com N-(β-aminoetil)-γ-aminopropiltrimetóxisilano. Os íons cobre ( This work describes the construction of a silicon microchip for retention of copper(II) metal ions. Conventional photolithographic process was applied to transfer the generated pattern to silicon wafers. Using Reactive Ion Etching (RIE), SF 6 based, channels 50 μm wide and 10 μm deep were produced. The channels were sealed with borosilicate glass using anodic bonding process. The surface of the channels were modified with N-(β-aminoethyl)-γ-aminopropyltrimetoxysilane through a silanization reaction to promote the adsorption of copper(II) ions. An amperometric detector was placed at the microchip outlet and copper(II) ions were detected by a gold electrode at 0 V (against Ag/AgCl (KCl sat.) reference electrode). Copper(II) ions were retained and eluted with HCl 50 μmol L -1 in a micro-flow system at a flow rate about 100 μL min -1 . Reproducibility in the peak area and height were about 4.6 % and 10 %, respectively, for three consecutive injections of 600 μL of 10 μmol L -1 copper(II) sample.

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Sample pretreatment on microfabricated devices

Cited by 183 publications

References 91 publications

Electroanalytical Flow Measurements–Recent Advances

Electroanalytical Flow Measurements–Recent Advances

Direct Observation of Dispersion and Mixing Processes in Microfluidic Systems

Retention of copper(II) metal ions in a silicon-glass microfluidic device

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