This paper is concerned with sampled-data control problem for a class of nonlinear systems with input quantization. The nonlinear system is converted into a linear-like system with modeling error by using partition of unity method. A time-dependent Lyapunov functional is introduced to capture the characteristic of nonlinear sampled-data systems and the exponential stability conditions are derived by the use of inequality techniques. The desired sampled-data controller is then synthesized. An example is provided to illustrate the effectiveness and benefits of the proposed scheme.