San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

Lo, Yi-Ching; Lin, Ying-Chi; Yu, Kwong-Leung; Lai, Yu‐Hung; Wu, Yang Chang; Ann, L. M.; Chen, I. J.

doi:10.1016/j.jep.2005.03.015

Cited by 52 publications

(43 citation statements)

References 30 publications

(35 reference statements)

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“…The mechanism of action of these benefits produced by post-treatment with SHXT includes attenuating expression of iNOS, ICAM-1, TGF-␤ and phosphorylation of p38 MAP kinase in lung tissues and decreasing MCP-1, IL-1␤ and TNF-␣ in plasma levels of LPS-exposed rats (Lo et al, 2005a). Our recently study also revealed that SHXT reduced H. pylori-induced inflammation on AGS cells and confirmed the gastric protection of SHXT (Shih et al, 2007).…”

Section: Fig 4 Inhibitory Effect Of Shxt On U46619-induced Pde5 Ovesupporting

confidence: 76%

“…Post-treatment with SHXT attenuated LPS-induced inflammatory responses (Lo et al, 2005a), lung edema and lethality (Lo et al, 2005b). Furthermore, our report also showed that SHXT reduced H. pylori-induced inflammation on AGS cells (Shih et al, 2007).…”

Section: Introductionsupporting

confidence: 68%

“…injury of LPS-treated rats (Lo et al, 2005a). The mechanism of action of these benefits produced by post-treatment with SHXT includes attenuating expression of iNOS, ICAM-1, TGF-␤ and phosphorylation of p38 MAP kinase in lung tissues and decreasing MCP-1, IL-1␤ and TNF-␣ in plasma levels of LPS-exposed rats (Lo et al, 2005a).…”

Section: Fig 4 Inhibitory Effect Of Shxt On U46619-induced Pde5 Ovementioning

confidence: 99%

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Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Tsai

Chen

2008

Journal of Ethnopharmacology

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Section: Fig 4 Inhibitory Effect Of Shxt On U46619-induced Pde5 Ovesupporting

confidence: 76%

Section: Introductionsupporting

confidence: 68%

Section: Fig 4 Inhibitory Effect Of Shxt On U46619-induced Pde5 Ovementioning

confidence: 99%

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Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Tsai

Chen

2008

Journal of Ethnopharmacology

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“…Among them, traditional oriental medicines have been gaining great interest. Several traditional oriental medicines, including san-huangxie-xin-tang (5), Clematis mandshurica Rupr (6), Quercus infectoria (7), have been investigated for their anti-inflammatory effects. No satisfactory results, however, have been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats

Lee

Ko³

2012

BMB Reports

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To investigate the therapeutic effect of a Korean herbal medicine Pulsatilla koreana as an anti-septic agent, anti-inflammatory effects of the herbal medicine were determined in lipopolysaccharide (LPS)-exposed rats. Treatment with a methanol extract from Pulsatilla koreana significantly inhibited LPS-induced inflammatory responses. Results from ELISA analysis showed that Pulsatilla koreana decreased the plasma and hepatic levels of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α while increased the level of anti-inflammatory cytokine IL-10 in LPS-exposed rats. Pulsatilla koreana also decreased the plasma levels of other inflammatory mediators such as NO3

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“…BA is known for its anti-inflammatory and smooth muscle relaxant properties and as a constituent of some hepatoprotective herbal mixtures such as Xiaochahu-tang (Sho-saiko-to), popular in Japan and China (2)(3)(4). Previous studies have shown that 100 µg/mL BA inhibits by 98% in vitro superantigenic staphylococcal exotoxin-stimulated T-cell proliferation and production of IL-1ß, TNF-α, IFN-γ by peripheral blood mononuclear cells, a Th1-type immune response (5,6).…”

Section: Introductionmentioning

confidence: 99%

Baicalin reduces the severity of experimental autoimmune encephalomyelitis

Zeng

Song

Xin-sheng

et al. 2007

Braz J Med Biol Res

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Scutellaria baicalensis Georgi is one of the important medicinal herbs widely used for the treatment of various inflammatory diseases in Asia. Baicalin (BA) is a bioactive anti-inflammatory flavone found abundantly in Scutellaria baicalensis Georgi. To explore the therapeutic potential of BA, we examined the effects of systemic administration of the flavone (5 and 10 mg/kg, ip) on relapsing/remitting experimental autoimmune encephalomyelitis (EAE) induced by proteolipid protein 139-151 in SJL/J mice, an experimental model of multiple sclerosis. The mice treated with PBS or BA at day -1 and for 3 consecutive days were observed daily for clinical signs of disease up to 60 days after immunization. In the PBS-EAE group, neurological scores were: incidence (100%), mean day of onset (8.0 ± 0.73), peak clinical score (3.0 ± 0.4), and cumulative disease index (141.8 ± 19.4). In the BA-EAE group (5 or 10 mg kg -1 day -1 , respectively), incidence (95 or 90%), mean day of onset (9.0 ± 0.80 or 9.2 ± 0.75; P = 0.000), peak clinical score (2.2 ± 0.3 or 2.0 ± 0.3; P = 0.000), and cumulative disease index (75.9 ± 10.1 or 62.9 ± 8.4; P = 0.000) decreased, accompanied by the histopathological findings (decrease of dense mononuclear infiltration surrounding vascellum) for the spinal cord. Additionally, the in vitro effects of BA (5, 10, and 25 µM) on mononuclear cells collected from popliteal and inguinal lymph nodes of day-10 EAE mice were evaluated using an MTT reduction assay for cell proliferation, and ELISA to measure IFN-γ and IL-4 cytokines. Compared with the control group, BA caused an increase in IL-4 (EAE-DMSO: 3.56 ± 0.42 pg/mL vs EAE-BA (5, 10, and 25 µM): 6.03 ± 1.1, 7.83 ± 0.65, 10.54 ± 1.13 pg/mL, respectively; P < 0.001); but inhibited IFN-γ (EAE-DMSO: 485.76 ± 25.13 pg/mL vs EAE-BA (5, 10, and 25 µM): 87.08 ± 9.24, 36.27 ± 5.44, 19.18 ± 2.93 pg/mL, respectively; P < 0.001) and the proliferation of mononuclear cells (EAE-DMSO: 0.73 ± 0.021 vs EAE-BA (5, 10, and 25 µM): 0.41 ± 0.015, 0.31 ± 0.018, 0.21 ± 0.11, respectively; P < 0.001) in a concentration-dependent manner. The results suggest that BA might be effective in the treatment of multiple sclerosis.

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San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

Cited by 52 publications

References 30 publications

Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats

Baicalin reduces the severity of experimental autoimmune encephalomyelitis

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