San-Huang-Xie-Xin-Tang reduces lipopolysaccharides-induced hypotension and inflammatory mediators

Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells

“…C. chinensis is one of the herbal plants formulated for Huang-Lian-JieDu decoction (HLJDD) and Xiexin decoction (XXD), which have been used to treat inflammation for nearly two thousand years in the clinical practice of Traditional Chinese Medicine. HLJDD and XXD have been reported to attenuate inflammatory responses in carrageenan-induced mice paw edema and LPS-exposed rats (Lo et al, 2005a(Lo et al, , 2005bLu et al, 2011). In this study, coptisine was also found to suppress carrageenan-induced rats paw edema and production of NO and TNF-α in inflamed tissues, suggesting that coptisine is one of major constituents for the anti-inflammatory effects of HLJDD and XXD.…”

Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC‐ESI‐MS/MS: application in pharmacokinetics

“…Modern pharmacological studies revealed that XXD has a variety of effects, such as anti-inflammation (Ma et al, 2009;Lo et al, 2005), antimicrobial (Yu et al, 2005), gastric protection (Saegusa et al, 2003), and anti-hypertension (Sanae et al, 2001). XXD is commonly employed to treat dysentery, arrhythmia, diabetes mellitus and inflammation-related diseases in the clinical setting.…”

San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

“…In our previous study, we have analyzed its components and, in spite of other unknown chemical components included in SHXT, baicalin is the most abundant one. The preventive effects of SHXT on LPS-induced reactions such as generation of cytokines, iNOS, COX-2, PGE 2 and arterial hypotension were studied in Wistar rats and RAW 264.7 macrophages (Lo et al, 2005). However, therapeutic effect of SHXT on lung injury has not been elucidated.…”