Sandalwood oil prevents skin tumour development in CD1 mice

Dwivedi, Chandradhar; Zhang, Y

doi:10.1097/00008469-199910000-00011

Cited by 38 publications

(21 citation statements)

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“…This oil is widely used in aromatherapy and it is employed by industry as an ingredient of perfumes and cosmetics. Furthermore, several biological activities have been reported, including the antidepressant, anti-inflammatory, antifungal, antiviral [2], anticarcinogenic [3] and antitumorous [4,5] ones.…”

Section: Introductionmentioning

confidence: 99%

Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography–two-dimensional gas chromatography for the collection of volatile constituents

Pantò¹,

Sciarrone²,

Maimone³

et al. 2015

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography–two-dimensional gas chromatography for the collection of volatile constituents

Pantò¹,

Sciarrone²,

Maimone³

et al. 2015

Journal of Chromatography A

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“…It is interesting that although sandalwood oil has been utilized by cultures across the world for its health benefits for centuries, very few studies on the chemopreventive properties of the oil have been published [2, 5]. We propose that there are several potential mechanisms by which EISO may act as a chemopreventive agent, and in the current study we investigated the effect of EISO on apoptosis and cell death, cell proliferation, and inhibition of key signaling pathways that mediate the cellular response to UV.…”

Section: Discussionmentioning

confidence: 99%

A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes

Dickinson¹,

Olson²,

Levenson³

et al. 2014

Archives of Biochemistry and Biophysics

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One of the primary components of the East Indian sandalwood oil (EISO) is α-santalol, a molecule that has been investigated for its potential use as a chemopreventive agent in skin cancer. Although there is some evidence that α-santalol could be an effective chemopreventive agent, to date, purified EISO has not been extensively investigated even though it is widely used in cultures around the world for its health benefits as well as for its fragrance and as a cosmetic. In the current study, we show for the first time that EISO-treatment of HaCaT keratinocytes results in a blockade of cell cycle progression as well as a concentration-dependent inhibition of UV-induced AP-1 activity, two major cellular effects known to drive skin carcinogenesis. Unlike many chemopreventive agents, these effects were not mediated through an inhibition of signaling upstream of AP-1, as EISO treatment did not inhibit UV-induced Akt, or MAPK activity. Low concentrations of EISO were found to induce HaCaT cell death, although not through apoptosis as annexin V and PARP cleavage were not found to increase with EISO treatment. However, plasma membrane integrity was severely compromised in EISO-treated cells, which may have led to cleavage of LC3 and the induction of autophagy. These effects were more pronounced in cells stimulated to proliferate with bovine pituitary extract and EGF prior to receiving EISO. Together, these effects suggest that EISO may exert beneficial effects upon skin, reducing the likelihood of promotion of pre-cancerous cells to actinic keratosis (AK) and skin cancer.

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“…Mariegold (http://www.mdidea.com, 2005) shows negative test against microbiology control E-coli and salimonella. Chemo-preventative effects (Dwivedi & Ghazaleh, 1997;Dwivedi & Zhang, 1999;Benencia & Courreges, 1999) of red sandal wood oil are observed on skin papillomas in mice. Further, it is studied for red sandal wood's prevention of skin tumor development in CD1 mice and antiviral activity against herpes simplex virus-1 and 2.…”

Section: Test Of Toxicity Biotechnological Processing and Environmenmentioning

confidence: 99%

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2011

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Sandalwood oil prevents skin tumour development in CD1 mice

Cited by 38 publications

References 0 publications

Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography–two-dimensional gas chromatography for the collection of volatile constituents

Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography–two-dimensional gas chromatography for the collection of volatile constituents

A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes

Dyeing of Textiles with Natural Dyes

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