In order to recycle the boulder powder produced in the process of manufactured sand production and reduce the cost of engineering concrete, this article studied the influence of boulders powder on the compressive strength of concrete. The results show that in the early stage of concrete test, the compressive strength of rock powder concrete is slightly lower than of fly ash and mineral powder concrete. With the development of curing age, the strength of boulders powder concrete developed slower. As the increase of boulders powder content, the compressive strength of different curing age gradually decreased, and it was suggested that the content of boulders powder should be controlled within 20% of cementitious materials mass. The positive effect of boulders powder fineness on the strength of concrete is limited, so it is suggested to use unprocessed collected boulders powder in the project, which is economical and environmentally friendly. With the adjustment of water-to-binder ratio, boulders powder can be prepared with different strength grades of concrete to meet the needs of engineering; the composite of boulders powder with traditional mineral admixtures, such as fly ash, and especially granulated blast furnace slag powder, can significantly improve the strength of concrete.