Sanguinarine in Chelidonium majus induced antifeeding and larval lethality by suppressing food intake and digestive enzymes in Lymantria dispar

Zou, Chuanshan; Wang, Yajun; Zou, Hang; Ding, Nan; Geng, Nannan; Cao, Chuanwang; Zhang, Guocai

doi:10.1016/j.pestbp.2018.10.003

Cited by 35 publications

(16 citation statements)

References 63 publications

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“…51 In 2018, compound 61 as well as four other bisbenzylisoquinoline alkaloids, liensinine (62), isoliensinine (63), norisoliensinine (64), and 6-hydroxynorisoliensinine (65) were found in P. nelumbinis. 30 Five alkaloids also were isolated from Alseodaphne corneri, including (−)-gyrolidine (66), (+)-O-methyllimacusine (67), (+)-2-norobaberine (68), (+)-norstephasubine (69), and (+)-stephasubine (70) 52 ( Figure 4).…”

Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

“…Benzophenanthridine isoquinoline compounds occur only in higher plants and show a wide spectrum of nonspecific biological activities as well as multiple pharmacological properties. Sanguinarine ( 299 ) (Figure 15), the most extensively studied alkaloid of this group, exhibits many biological effects, such as antibacterial, 135 antifungal, 136,137 anti‐inflammatory, 138 antioxidant, 139 antiviral, 140 nematicidal, 141 antitumor, 142 immunomodulatory, 143 and insecticidal 69,92 activities.…”

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

147

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

147

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“…Diverse living surroundings mean more abundant stressors. Numerous research were devoted to study how gypsy moths responded to the stressors, such as heavy metal (Jiang, Dong, & Yan, ; Jiang & Yan, ), pathogenic microorganism (Yanar, Gömeç, Topkara, Solmaz, & Demir, ), and other pesticides and potential pesticides (Aslanturk, Kalender, Uzunhisarcikli, & Kalender, ; Zou et al, ). Ambient temperature was defined as a critical factor that can disrupt normal host homeostasis and develop both specific and nonspecific host immunity response (Prophete et al, ).…”

Section: Introductionmentioning

confidence: 99%

Ambient temperature‐mediated enzymic activities and intestinal microflora in Lymantria dispar larvae

Zeng

Shi

et al. 2019

Arch Insect Biochem Physiol

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To understand how ambient temperature affect the gypsy moth larvae, and provide a theoretical basis for pest control in different environments. Fourth instar gypsy moth larvae were incubating for 3 hr at 15℃, 20℃, 25℃, 30℃, 35℃, and 40℃, respectively. Afterward, digestive and antioxidant enzyme activities, total antioxidant capacity, and intestinal microflora community were analyzed to reveal how the caterpillars respond to ambient temperature stress. Results showed that both digestive and antioxidant enzymes were regulated by the ambient temperature. The optimum incubation temperatures of protease, amylase, trehalase, and lipase in gypsy moth larvae were 30℃, 25℃, and 20℃, respectively. When the incubation temperature was deviated optimum temperatures, digestive enzyme activities would be downregulated depending on the extent of temperature stress. In addition, glutathione S‐transferase, peroxidase, catalase, and polyphenol oxidase would be activated under a sufferable temperature stress, but superoxide dismutase and carboxylesterase (CarE) would be inhibited. In addition, results showed that the top two abundant phyla were Proteobacteria and Firmicutes. The phylum Firmicutes abundance was decreased and phylum Proteobacteria abundance was increased by ambient temperature stress. Moreover, it suggested that gypsy moth caterpillars at different ambient temperature mainly differed from each other by Escherichia‐Shigella and Bifidobacterium in control, Acinetobacter in T15, and Lactobacillus in T40, respectively.

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“…In sows, as well as in other species, it has been shown that insulin resistance appears during late gestation, as an adaptation to the high glucose demands of pregnancy [ 43 ]. Furthermore, sanguinarine has been shown to inhibit digestive enzyme activities (amylase, lipase and protease) and their relative expression in the digestive tract of Lepidoptera larvae [ 44 ]. Thus, sanguinarine and other isoquinoline alkaloids may have potential as anti-diabetic molecules and could have effects on pancreatic function, but further research is needed.…”

Section: Discussionmentioning

confidence: 99%

Isoquinoline Alkaloids in Sows’ Diet Reduce Body Weight Loss during Lactation and Increase IgG in Colostrum

Sureda

Zhao

Artuso-Ponte

et al. 2021

Animals

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Isoquinoline alkaloids (IQ) exert beneficial antimicrobial and anti-inflammatory effects in livestock. Therefore, we hypothesized that supplementing sows’ diets with IQ during gestation would decrease farrowing stress, affecting the piglets’ development and performance. Sows were divided into: IQ1, supplemented with IQ from gestation day 80 (G80) to weaning; IQ2, supplemented from gestation day 110 (G110) to weaning, and a non-supplemented (NC) group. Sow body weight (BW), feed intake, back-fat thickness and back-muscle thickness were monitored. Cortisol, glucose and insulin were measured in sows’ blood collected 5 d before, during, and after 7 d farrowing. Protein, fat, IgA and IgG were analyzed in the colostrum and milk. Piglets were monitored for weight and diarrhea score, and for ileum histology and gene expression 5 d post-weaning. IQ-supplemented sows lost less BW during lactation. Glucose and insulin levels were lower in the IQ groups compared to NC-sows 5 d before farrowing and had higher levels of protein and IgG in their colostrum. No other differences were observed in sows, nor in the measured parameters in piglets. In conclusion, IQ supplementation affected sows’ metabolism, reducing body weight loss during lactation. Providing IQ to sows from their entrance into the maternity barn might be sufficient to induce these effects. IQ improved colostrum quality, increasing the protein and IgG content, improving passive immunity for piglets.

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Sanguinarine in Chelidonium majus induced antifeeding and larval lethality by suppressing food intake and digestive enzymes in Lymantria dispar

Cited by 35 publications

References 63 publications

Biologically active isoquinoline alkaloids covering 2014–2018

Biologically active isoquinoline alkaloids covering 2014–2018

Ambient temperature‐mediated enzymic activities and intestinal microflora in Lymantria dispar larvae

Isoquinoline Alkaloids in Sows’ Diet Reduce Body Weight Loss during Lactation and Increase IgG in Colostrum

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