SANS Characterization of an Anisotropic Poly(vinyl alcohol) Hydrogel with Vascular Applications

Millon, Leonardo E.; Nieh, Mu‐Ping; Hutter, Jeffrey L.; Wan, Wankei

doi:10.1021/ma062781f

Cited by 88 publications

(103 citation statements)

References 35 publications

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“…Such factors may influence the motion of the biomodeling when there is pulsatile flow in its lumen, as may the mechanical interaction between the biomodeling and the interventional devices during the training of endovascular intervention. Methods of representing these factors of a blood vessel with PVA-H have been reported by Wan et al (23) and Millon et al (24), (25) . Wan et al first indicated that PVA-H can represent the nonlinearity of a blood vessel in a tensile test by performing freeze-thaw cycles, which is a method in which PVA gel is repeatedly frozen and thawed.…”

Section: Discussionmentioning

confidence: 99%

Measurements of Dynamic Viscoelasticity of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling

Kosukegawa

Mamada²,

Kuroki

et al. 2008

JFST

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In vitro blood vessel biomodeling with realistic mechanical properties and geometrical structures is helpful for training in surgical procedures, especial those used in endovascular treatment. Poly (vinyl alcohol) hydrogel (PVA-H), which is made of Poly (vinyl alcohol) (PVA) and water, may be useful as a material for blood vessel biomodeling due to its low surface friction resistance and good transparency. In order to simulate the mechanical properties of blood vessels, measurements of mechanical properties of PVA-H were carried out with a dynamic mechanical analyzer, and the storage modulus (G') and loss modulus (G'') of PVA-H were obtained. PVA-Hs were prepared by the low-temperature crystallization method. They were made of PVA with various concentrations (C) and degrees of polymerization (DP), and made by blending two kinds of PVA having different DP or saponification values (SV). The G' and G'' of PVA-H increased, as the C or DP of PVA increased, or as the proportion of PVA with higher DP or SV increased. These results indicate that it is possible to obtain PVA-H with desirable dynamic viscoelasticity. Furthermore, it is suggested that PVA-H is stable in the temperature range of 0°C to 40°C, indicating that biomodeling made of PVA-H should be available at 37°C, the physiological temperature. The dynamic viscoelasticity of PVA-H obtained was similar to that of the dog blood vessel measured in previous reports. In conclusion, PVA-H is suggested to be useful as a material of blood vessel biomodeling.

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Section: Discussionmentioning

confidence: 99%

Measurements of Dynamic Viscoelasticity of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling

Kosukegawa

Mamada²,

Kuroki

et al. 2008

JFST

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“…[87][88][89] Recent work resulted in a strain-induced aligned hydrogel that has extremely high Adv. Mater.…”

Section: Mechanical Strainmentioning

confidence: 99%

“…[88] During the prestretching process, polymer chains of chemically crosslinked poly(acrylic acid-co-acrylamide) hydrogels could be aligned along the stretched direction at the molecular scale. Then, Fe 3+ -mediated physical crosslinking fixed this structure and improved the mechanical strength of the aligned network.…”

Section: Mechanical Strainmentioning

confidence: 99%

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their “soft and wet” properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited. Inspired by biological soft tissues with well‐ordered structures, researchers have increasingly investigated highly ordered nanocomposite hydrogels as functional biological engineering soft materials with unique mechanical, optical, and biological properties. These hydrogels incorporate long‐range ordered nanocomposite structures within hydrogel network matrixes. Here, the critical design criteria and the state‐of‐the‐art fabrication strategies of nanocomposite hydrogels with highly ordered structures are systemically reviewed. Then, recent progress in applications in the fields of soft actuators, tissue engineering, and sensors is highlighted. The future development and prospective application of highly ordered nanocomposite hydrogels are also discussed.

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“…That being said, the use of hydrogels as cryoprotectants for cells in conjunction with cryogelation processes has been demonstrated to successfully create cell-loaded macroporous gel scaffolds, albeit with some loss of cell activity following the freezing process. [70] Furthermore, although the rates of heating and cooling and the number of freeze/thaw cycles conducted can at least in part be used to rationally control the pore size and distribution generated, [71,72] the generated pores still typically have a broad pore size distribution and minimal if any directionality. Tam et al have demonstrated the possible benefits of adding typical cryoprotectant carbohydrates such as d-galactose, d-glucose, d-trehalose, or d-sucrose to the pre-gel solution, as all these sugars interact with water to alter the nature of ice crystallization and thus create more transparent hydrogels with improved pore size control.…”

Section: Cryogelationmentioning

confidence: 99%

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Hoare

2017

Adv Healthcare Materials

178

168

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Structured macroporous hydrogels that have controllable porosities on both the nanoscale and the microscale offer both the swelling and interfacial properties of bulk hydrogels as well as the transport properties of “hard” macroporous materials. While a variety of techniques such as solvent casting, freeze drying, gas foaming, and phase separation have been developed to fabricate structured macroporous hydrogels, the typically weak mechanics and isotropic pore structures achieved as well as the required use of solvent/additives in the preparation process all limit the potential applications of these materials, particularly in biomedical contexts. This review highlights recent developments in the field of structured macroporous hydrogels aiming to increase network strength, create anisotropy and directionality within the networks, and utilize solvent‐free or additive‐free fabrication methods. Such functional materials are well suited for not only biomedical applications like tissue engineering and drug delivery but also selective filtration, environmental sorption, and the physical templating of secondary networks.

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SANS Characterization of an Anisotropic Poly(vinyl alcohol) Hydrogel with Vascular Applications

Cited by 88 publications

References 35 publications

Measurements of Dynamic Viscoelasticity of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling

Measurements of Dynamic Viscoelasticity of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

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