Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Shah, Bhahwal Ali; Chib, Reena; Gupta, Pankaj; Sethi, Vijay; Koul, Surrinder; Andotra, Samar S.; Nargotra, Amit; Sharma, Sujata; Pandey, Anjali; Bani, Sarang; Purnima, Basant; Taneja, Subhash C.

doi:10.1039/b902041a

Cited by 35 publications

(13 citation statements)

References 34 publications

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“…Some saponin rich extracts are well demonstrated to process anti-oxidative, anti-inflammatory (Wang et al, 2008) and anti-neuralgic (Kaur et al, 2010) effects in animal studies. Moreover, some saponins have also been reported to cause inhibition of calcium accumulation and reduction of TNF-a levels (Shah et al, 2009;Kaur et al, 2010). Further it has been well documented that massive rise in free radicals and calcium levels induce oxidative stress and neuro-inflammation (Honda et al, 2004;.…”

Section: Discussionmentioning

confidence: 98%

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

Muthuraman

Singh

2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 98%

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

Muthuraman

Singh

2012

Journal of Ethnopharmacology

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“…Results of analysis of three principal components between the levels of secondary metabolites (tannins (TAN), phenols (FEN), cyanogenic glycosides (GLUC), alkaloids (ALC) and saponins (SAP)) and cytotoxic activity expressed in LC 50 present in five selected medicinal plants. hysterophorus se reportó que fueron aisladas dos nuevas saponinas terpenoides, las cuales resultaron ser potentes inhibidores del factor de necrosis tumoral alfa (TNF-α) (Shah et al, 2009 (2003) no encontraron actividad hemolítica producida por el extracto de la planta. Para A. absinthium, C. aconitifolius y P. carpunya, solamente en la literatura se han reportado análisis cualitativos que indican la presencia de saponinas.…”

Section: Discussionunclassified

Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Jaramillo-Jaramillo

Jaramillo-Espinoza

D’Armas

et al. 2016

RBT

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Concentraciones de alcaloides, glucósidos cianogénicos, polifenolesy saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina Alcoholic and aqueous extracts from leaves of these selected plants were prepared at different concentrations. To assess cytotoxicity of these extracts, different bioassays with A. salina were undertaken, and the mortality rates and LC 50 were obtained. Besides, concentrations of alkaloids, cyanogenic glycosides, phenols, tannins and saponins were determined by spectrophotometric methods; this constituted the first report of quantification of secondary metabolites in the selected plants from Ecuador. T. officinale had the highest concentration of total phenols (22.30 ± 0.23 mg/g) and tannins (11.70 ± 0.10 mg/g), C. aconitifolius of cyanogenic glycosides (5.02 ± 0.37 µg/g) and P. hysterophorus of saponins (6.12 ± 0.02 mg/g). Tannins values obtained were not adverse to their consumption. Alcoholic and aqueous extracts of selected plants had hemolytic activity depending on the concentration of saponins. Although the values of cyanogenic glycosides were permissible, it was necessary to monitor the presence of this metabolite in plants to minimize health problems. LC 50 values ranged from extremely toxic (3.37 µg/mL) to highly toxic (274.34 μg/mL), in P. carpunya and T. officinale, respectively. From correlation analysis, it was observed that increase values of alkaloids concentrations had highly significant (p<0.001) acute toxicity against A. salina, while at a higher polyphenol concentration the level of plants cytotoxicity decreased significantly (p<0.001). The results of principal component analysis showed that saponins apparently were in synergy with polyphenols to decrease cytotoxicity, but antagonize with alkaloids and cyanogenic glycosides, indicating that these secondary metabolites present variability in the mechanisms of action against A. salina, as cytotoxic compounds. These results also demonstrate that polyphenols and saponins can be lethal at low concentrations, demonstrating the potential of brine shrimp bioassay as a model to evaluate plant extracts containing low concentrations of chemical compounds with high polarities. The significant positive correlation between cytotoxicity and concentration of alkaloids confirmed by the bioassay of brine shrimp can be useful to identify promising sources of antitumor compounds, and to evaluate tolerable limits not affecting other benign cells. Contents of secondary metabolites found in the selected plants confer them great pharmacologic values. Rev. Biol. Trop. 64 (3):

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“…The decay in dynamic surface tension over increasing PHCE and PHNE concentrations indicates that both treatments were surface active and can reduce the surface tension of pure distilled water from 72.94 to 38.62 mN m 1 for PHCE and from 72.94 to 37.32 mN m 1 for PHNE. In this study, PHCE contained saponin 30 which work as a natural emulsifier by having hydrophobic parts from triterpene or steroid backbone covalently bond to hydrophilic parts such as carbohydrate groups 31 . While the present of surfactant Tensiofix and Tween 80 in PHNE have in-creased the ability of PHCE in reducing the interfacial tension of water.…”

Section: Surface Tension Analysismentioning

confidence: 99%

Optimization and Characterization of Palm Oil-based Nanoemulsion Loaded with <i>Parthenium hysterophorus</i> Crude Extract for Natural Herbicide Formulation

et al. 2019

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Introduction Parthenium hysterophorus is one of the world s seven most devastating and aggressive weed commonly known as carrot grass and bitter weed 1. The Asteraceae family belonging weeds were often spotted on abandoned lands, drainage and railway tracks. Parthenium hysterophorus contained allelochemical parthenin which play as a major phytotoxic compound in the plant. Allelochemical is a chemical compound that influences growth, survival, and reproduction of other organism 2. Due to its noxious ability, P. hysterophorus could be exploited as a potential bioactive component in herbicide formulation for natural weed management 3 .

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Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Cited by 35 publications

References 34 publications

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Optimization and Characterization of Palm Oil-based Nanoemulsion Loaded with <i>Parthenium hysterophorus</i> Crude Extract for Natural Herbicide Formulation

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