Saponins from Chinese folk medicine, "zhu jie xiang fu," Anemone raddeana Regel.

Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from <i>Anemone raddeana</i>

“…Therefore, the reaction temperature was raised to 0°C, so that the reaction could be completed successfully in 1 h with a 75% yield of the product 9. Then, the O-benzoyl groups of 9 were removed by NaOMe-MeOH to give 10, and benzylidene was introduced to protect 4″,6″-OH by the reaction of 10 with PhCH(OMe) 2 and p-toluenesulfonic acid in dry DMF to give diol 11. 16,17) The key step is the regioselective protection of the hydroxyl groups at C-2″ and C-3″ of 11.…”

“…The dry rhizome of Anemone raddeana REGEL (Ranunculaceae), a very important Chinese folk medicine, was used to treat rheumatism and neuralgia. [1][2][3] During the past 30 years, most of the studies focused on the isolation of alcohol extracts of this medicinal plant and more than thirty oleanane-type triterpenoid saponins have been identified. [4][5][6][7][8] Recent studies have suggested that one of these triterpenoid saponins, Raddeanin A (1), exhibited cytotoxicity in vitro.…”

Rapid determination of volatile composition from Polygala furcata Royle by MAE–HS-SPME followed by GC–MS

“…In recent years, studies on focused mainly on P. tenuifolia Willd, P. tatarinowii Regel, P. sibirca Linn and P. japonica Houtt, the literature reported that various types of activity constituents were separated from P. tenuifolia Willd, P. tatarinowii Regel, P. sibirca Linn and P. japonica Houtt, they are mainly saponins, ketones and sugar esters, and so on [4][5][6][7][8][9]. However, so far, the essential oils components in P. furcata Royle have not received much attention.…”

A new triterpenoid saponin from Anemone raddeana

“…Triterpenoid saponins are the main effective components. Up to now, eighteen new triterpenoid saponins have been reported from this plant [2][3][4][5][6][7][8]. From the water-soluble part, we again obtained several new triterpenoid saponins with more than nine sugar units.…”