Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors

Wang, Dong-Fan; Zhou, Zhi; Zhang, Xulan; Zhang, Changcheng; He, Yumin; Liu, Chaoqi; Yuan, Chengfu; Yuan, Ding; Wang, Ting

doi:10.1016/j.neuint.2021.105098

Cited by 15 publications

(4 citation statements)

References 45 publications

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“…Obesity can lead to behavioral alterations such as cognitive dysfunction and depression-like behaviors in both humans and rodents [ 70 ]. Saponins from P. japonicus treatment have been shown to alleviate high-fat diet (HFD)-induced recognitive impairment and depression-like behaviors in HFD-fed Balb/c mice, which could partly be due to the ability of saponins from P. japonicus to mitigate neuroinflammation through inhibition of NLRP3 inflammasome (NLRP3, caspase-1, ASC, and IL-1β) and upregulation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors signaling pathway [ 71 ]. Saponin fraction of KRG reveals an anti-inflammatory effect by ameliorating the mRNA expression of genes encoding NLRP3 inflammasome components (Nlrp3, Asc, pro-IL-1β, IL-1β, pro-caspase-1, and caspase-1) in cultured ovaries from aged C57BL/6 mice [ 72 ] ( Table 1 ).…”

Section: P Ginseng As a Potential Therapeutic For Neurologic...mentioning

confidence: 99%

Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Shin

Cho

2023

Journal of Ginseng Research

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Section: P Ginseng As a Potential Therapeutic For Neurologic...mentioning

confidence: 99%

Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Shin

Cho

2023

Journal of Ginseng Research

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“…168 Additionally, CY-09, a selective inhibitor of NLRP3, could regulate the NLRP3/ASC/cytokine signaling pathway in the HC of the LPS-induced animal model of depression. 169 Natural product ingredients such as Morinda off icinalis, 170 catalpol (from the root of Rehmannia glutinosa Libosch), 171 Xin San (a traditional Chinese medicinal formula), 172 ganoderic acid A (found in Ganoderma mushrooms), 173 albiflorin (from the roots of Paeonia lactif lora), 174 and saponins (from Panax japonicas) 175 effectively suppress NLRP3, contributing to their significant antidepressant effects. Therefore, targeting the NLRP3 inflammasome offers the potential for depression treatment, with various agents and natural compounds showing promising results in modulating its activity.…”

Section: ■ Inhibition Of Inflammation and Nlrp3 For Treating Post-sci...mentioning

confidence: 99%

Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications

Mokhtari,

Uludag

2023

ACS Chem. Neurosci.

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The majority of research on the long-term effects of spinal cord injury (SCI) has primarily focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments. Among SCI patients, mood disorders, such as anxiety and depression, have been extensively studied. It has been found that chronic stress and NP have negative consequences and reduce the quality of life for individuals living with SCI. Our review examined both human and experimental evidence to explore the connection between mood changes following SCI and inflammatory pathways, with a specific focus on NLRP3 inflammasome signaling. We observed increased proinflammatory factors in the blood, as well as in the brain and spinal cord tissues of SCI models. The NLRP3 inflammasome plays a crucial role in various diseases by controlling the release of proinflammatory molecules like interleukin 1β (IL-1β) and IL-18. Dysregulation of the NLRP3 inflammasome in key brain regions associated with pain processing, such as the prefrontal cortex and hippocampus, contributes to the development of mood disorders following SCI. In this review, we summarized recent research on the expression and regulation of components related to NLRP3 inflammasome signaling in mood disorders following SCI. Finally, we discussed potential therapeutic approaches that target the NLRP3 inflammasome and regulate proinflammatory cytokines as a way to treat mood disorders following SCI.

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“…In addition, Ginsenoside Rg1 attenuates depressive-like behavior by regulating the NF-κB/NLRP3 pathway in chronic unpredictable mild-stress rats (Zhang et al 2019 ). Moreover, saponins from Panax japonicus alleviate HFD-induced depressive-like behaviors via inhibiting NLRP3 inflammasome (Wang et al 2021a ). Therefore, ginseng alleviates COVID-19 pandemic depression by regulating NLRP3 inflammasomes.…”

Section: Effects Of Ginseng On Covid-19 Pandemic Caused Depressionmentioning

confidence: 99%

Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19

Zhao,

Zhang,

Chen

et al. 2023

Inflammopharmacol

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Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients has increased, some of those infected with SARS-CoV-2 have developed a variety of psychiatric symptoms, including depression, cognitive impairment, and fatigue. A distinct storm of inflammatory factors that contribute to the initial disease but also a persistent post-acute phase syndrome has been reported in patients with COVID-19. Neuropsychological symptoms including depression, cognitive impairment, and fatigue are closely related to circulating and local (brain) inflammatory factors. Natural products are currently being examined for their ability to treat numerous complications caused by COVID-19. Among them, ginseng has anti-inflammatory, immune system stimulating, neuroendocrine modulating, and other effects, which may help improve psychiatric symptoms. This review summarizes the basic mechanisms of COVID-19 pneumonia, psychiatric symptoms following coronavirus infections, effects of ginseng on depression, restlessness, and other psychiatric symptoms associated with post-COVID syn-dromes, as well as possible mechanisms underlying these effects.

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Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors

Cited by 15 publications

References 45 publications

Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications

Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19

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