Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

Gao, Yan; Yuan, Ding; Gai, Liyue; Wu, Xuelian; Shi, Yue; He, Yumin; Liu, Chaoqi; Zhang, Changcheng; Zhou, Gang; Yuan, Chengfu

doi:10.1016/j.jgr.2020.08.005

Cited by 28 publications

(14 citation statements)

References 42 publications

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“…It was proved that aging stimulates inflammation response and provokes consequent renal fibrosis [ 62 ]. Indeed, during aging, inflammatory mediators are released and activate fibroblasts to initiate renal fibrosis [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

et al. 2022

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Natural polyphenols are widely reported to have a large range of pharmacological properties, especially antioxidant activities and free radical scavenging capacities. In this study, we investigate the effects of naringin, chlorogenic acid, and quercetin mixtures (NCQ) on renal fibrosis in streptozotocin (STZ)-induced diabetic aged rats and its underlying mechanisms for ten consecutive weeks. The oxidative defense system in the kidneys of treated rats was found to be improved. Several biomarkers were investigated including the blood urea nitrogen, creatinine, and uric acid. Moreover, antioxidant parameters were evaluated and we found that superoxide dismutase, catalase, glutathione peroxidase, Na+-K+-ATPase activities, the nitric oxide production, the protein carbonyl, the advanced oxidation protein products, lipid peroxidation, and reduced glutathione levels were all significantly balanced and close to control values. In addition, NCQ restored renal injuries and fibrosis as assessed by histological method and molecular biology investigation of the matrix metalloproteinase, the transforming growth factor-beta TGF-β, the tumor necrosis factor TNFα, and p53 expression. Our study proposes the NCQ combination as potential plant-derived bioactive compounds to prevent diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

et al. 2022

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“…Studies show that some natural products can treat agingrelated fibrosis by targeting the TGF-β signalling pathway [151][152][153] (Table 1). Saponins from Panax japonicus (SPJ) exert anti-inflammatory and antioxidative effects.…”

Section: Natural Productsmentioning

confidence: 99%

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

Ren¹,

Miao²,

Wang³

et al. 2023

Aging and disease

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Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue fibrosis. Numerous clinical investigations have shown a correlation between the degree of liver and pulmonary fibrosis in patients and telomere length and mitochondrial DNA content, both of which are signs of aging. Aging involves the gradual loss of tissue function over time, which results in the loss of homeostasis and, ultimately, an organism's fitness. A major feature of aging is the accumulation of senescent cells. Senescent cells abnormally and continuously accumulate in the late stages of life, contributing to age-related fibrosis and tissue deterioration, among other aging characteristics. Furthermore, aging generates chronic inflammation, which results in fibrosis and decreases organ function. This finding suggests that fibrosis and aging are closely related. The transforming growth factorbeta (TGF-β) superfamily plays a crucial role in the physiological and pathological processes of aging, immune regulation, atherosclerosis, and tissue fibrosis. In this review, the functions of TGF-β in normal organs, aging, and fibrotic tissues is discussed: TGF-β signalling is altered with age and is an indicator of pathology associated with tissue fibrosis. In addition, this review discusses the potential targeting of noncoding.

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“…These responses are a common pathological process that starts in the tissues and organs of the body. The anti-inflammatory effects of TQ involve multiple complex signaling pathways as well as molecular mechanisms, which mainly involve anti-inflammatory and antioxidant activity from the inhibition of oxidative stress [ 18 ].…”

Section: Tq Effect On Inflammationmentioning

confidence: 99%

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

Liu

Huang

Kim

et al. 2022

IJMS

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Anti-inflammatory therapies have been shown to be effective in the prevention of various cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main active constituent of Nigella sativa, has shown promising therapeutic properties in many in vivo and in vitro models. However, TQ has poor bioavailability and is hydrophobic, prohibiting clinical trials with TQ alone. Studies have explored the combination of TQ with biological nanomaterials to improve its bioavailability. The TQ nanoparticle formulation shows better bioavailability than free TQ, and these formulations are ready for clinical trials to determine their potential as therapeutic agents. In this paper, we review current knowledge about the interaction between TQ and the inflammatory response and summarize the research prospects in Korea and abroad. We discuss the different biological activities of TQ and various combination therapies of TQ and nanomaterials in clinical trials.

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Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

Cited by 28 publications

References 42 publications

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

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