Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice

Liu, Wencong; Zheng, Yi-Nan; Han, Li; Wang, Haimin; Saito, Masato; Ling, Mingsong; Kimura, Yoshiyuki; Feng, Yixiong

doi:10.1016/j.phymed.2008.07.002

Cited by 80 publications

(48 citation statements)

References 21 publications

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“…Fat absorption has often been reported to be suppressed by lipase inhibition (20)(21)(22)(23). Therefore, we investigated whether WEH affected pancreatic lipase activity in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-obesity effect of WEH was evaluated using obese mice that were fed a HFD with or without WEH for 11 wk. Female mice (3 wk old), but not male mice (6 wk old), were used in the experiment because it was easier to induce obesity in female mice by the HFD than in male mice (data not shown), and female mice (3-4 wk old) have been used in anti-obesity tests in previous studies (23,37,38). While there was hardly any difference in food intake between the HFD and WEH groups, the body-weight gain in the WEH groups was significantly lower than that in the HFD group (Fig.…”

Section: 29)mentioning

confidence: 99%

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Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

Miyata

Koyama

Yazawa

2010

J Nutr Sci Vitaminol

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Summary Houttuynia cordata Thunb. is used in folk medicine for diuresis and detoxification. However, it has not yet been reported to have an anti-obesity effect. We found that the water extract of H. cordata leaves (WEH) inhibited the corn oil-induced increase in plasma triglyceride levels in mice. WEH also inhibited the oleic acid-and glycerol-induced increase in the levels of plasma nonesterified fatty acids and glycerol, respectively. Moreover, WEH had anti-obesity effects in mice with high-fat-diet-induced obesity. Therefore, WEH may be able to prevent or reduce obesity induced by a high-fat diet. Key Words Houttuynia cordata Thunb., anti-obesity, fatty acid, glycerol, triglycerideObesity is an abnormal condition in which excessive triglycerides (TGs) accumulate in the adipose tissue. In Japan, the number of obese people older than 20 y (body mass index, Ͼ 25) has been increasing yearly because of inadequate exercise, westernization of diet, and irregular eating habits. According to a national health and nourishment investigation conducted by the Ministry of Health, Labour and Welfare in 2007, about 1 of 4 Japanese adults is obese. Obesity is the most important risk factor for lifestyle-related diseases such as hypertension, type 2 diabetes and hyperlipemia ( 1-4 ). In particular, obesity causes an imbalance in the level of adipocytokines secreted by adipocytes, such as leptin, adiponectin, resistin, and plasminogen activator inhibitor-1, due to the excessive accumulation of visceral fat, and can cause metabolic syndrome ( 5 , 6 ). Furthermore, when symptoms worsen, metabolic syndrome can develop into atherosclerotic disease, which is associated with a very high mortality rate ( 7 , 8 ). Therefore, it is important to prevent or reduce obesity to achieve a better health-related quality of life.Houttuynia cordata Thunb. (Saururaceae), which is called dokudami in Japanese, is widely distributed in eastern Asia, including China, Korea, and Japan, and is used in folk medicine for diuresis and detoxification. It contains many flavonoids (quercitrin, isoquercitrin, rutin, etc.), alkaloids (aristolactam B, norcepharadione B, splendidine, etc.), and volatile components of essential oils (methyl-n -nonyl ketone, lauraldehyde, ␤ -myrcene, etc.) ( 9-11 ). Thus far, the extracts and components of H. cordata have been demonstrated to exhibit antioxidative, antiviral, antibacterial, antihypertensive and anti-inflammatory effects ( 12-17 ). However, these extracts have not yet been reported to have anti-obesity effects. Therefore, in this study we examined the antiobesity action of H. cordata . MATERIALS AND METHODS Materials. The Free Glycerol Determination Kit andLipase Kit S were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA) and DS Pharma Biomedical Co. Ltd. (Osaka, Japan), respectively. Porcine pancreatic lipase was obtained from ICN Biomedicals (Aurora, OH, USA). The mouse diet was purchased from Oriental Yeast Co., Ltd. (Tokyo, Japan). The other materials were purchased from Wako Pure Chemical Industries, Ltd....

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“…Fat absorption has often been reported to be suppressed by lipase inhibition (20)(21)(22)(23). Therefore, we investigated whether WEH affected pancreatic lipase activity in vitro.…”

Section: Discussionmentioning

confidence: 99%

Section: 29)mentioning

confidence: 99%

Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

Miyata

Koyama

Yazawa

2010

J Nutr Sci Vitaminol

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“…51 Certain saponins such as oleanane, lupine and dammarane-type can inhibit pancreatic lipase activity and therefore have potential as treatments that could prove effective for obesity and related disorders. [52][53][54] However, the clinical potential of saponins remains difficult to judge with such limited clinical data available.…”

Section: Saponinsmentioning

confidence: 99%

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

Tucci¹

2010

DMSO

123

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“…It has been well documented that plant saponins, such as ginseng saponins, suppress pancreatic lipase and prevent high fat diet-induced obesity in mice (11,12). Therefore, there is a good possibility that soy saponins may also contribute to the inhibition of TG digestion by lipase.…”

Section: Discussionmentioning

confidence: 99%

Effects of Alternatively Prepared Meju Methanolic Extracts on Dietary Lipid Digestion

Kang¹,

Nam²,

Kim

2010

JFN

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We examined the effect of extracts of meju prepared with traditional and standardized methods on pancreatic lipase and the absorption of dietary lipid. Aqueous methanolic (80%, v/v) extracts of meju dose-dependently inhibited the activities of porcine pancreatic lipase. The plasma triglyceride levels in Imprinting Control Region mice after a single oral administration of lipid emulsion containing aqueous methanolic extracts from meju made by the standardized methods were lower than that of the group given a lipid emulsion containing the extracts of meju made by traditional methods. The inhibitory activity of the meju extract on dietary lipid digestion appears to be more closely associated with aglycone forms of phenolic compounds such as free isoflavones than with glycosides, since meju samples with higher total phenolic or free isoflavone content showed the stronger inhibition against pancreatic lipase. Furthermore, the data suggest that meju made using the standardized method, which contains higher levels of total isoflavones relative to traditionally prepared meju, could effectively suppress digestion of dietary lipids and therefore have the potential to help ameliorate hyperlipidemia and obesity.

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Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice

Cited by 80 publications

References 21 publications

Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

Effects of Alternatively Prepared Meju Methanolic Extracts on Dietary Lipid Digestion

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