Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase

Lande, Anirudha A.; Ambavade, Shirishkumar D.; Swami, Uma S.; Adkar, Prafulla P.; Ambavade, Prashant D.; Waghamare, Arun B.

doi:10.1016/s2095-4964(15)60157-1

Cited by 15 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many saponins isolated from medicinal plants have been informed to have antinociceptive and anti-inflammatory activities. For example, saponins separated from roots of Chlorophytum borivilianum significantly reduced histamine-and carrageenan-induced inflammation in rats (26). Saponin from Quillaja saponaria was also found to reduce the carrageenan induced inflammation in mice (27).…”

Section: Discussionmentioning

confidence: 98%

“…For example, saponins separated from roots of Chlorophytum borivilianum significantly reduced histamine-and carrageenan-induced inflammation in rats (26). Saponin from Quillaja saponaria was also found to reduce the carrageenan induced inflammation in mice (27). The saponin fraction of Zizyphus lotus was reported to alleviate paw edema and pain by inhibition of the nitrite production (28).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Astragalus fasciculifolius manna; antinociceptive, antiinflammatoryand antioxidant properties in mice

et al. 2020

View full text Add to dashboard Cite

Introduction: Inflammation is one of the body›s natural defence mechanisms alongside the cells or tissues damage due to various stimuli or infections. Pain is one of the greatest common symbols associated with different diseases. Therefore, researchers are trying to find new medications that bring patients relief with fewer side effects. Herbal medicine has been used for periods to treat acute and chronic pains. Objectives: This research evaluated the anti-inflammatory, antinociceptive and antioxidant properties of Astragalus fasciculifolius manna extract. Materials and Methods: The anti-inflammatory and antioxidant potency of the extract were determined by xylene test and ferric reducing antioxidant power assay. Results: Astragalus fasciculifolius manna extract at doses of 400, 800 and 1200 mg/kg significantly reduced acetic acid-induced writhing and formalin-induced paw licking (late and early phase) but did not affect mechanical hyperalgesia caused by heat. Moreover, naloxone failed to inhibit the antinociceptive activity of the extract. The extract of A. fasciculifolius manna also exhibited high anti-inflammatory activity against xylene induced ear edema. Treatment of mice with the extract did not improve serum antioxidant capacity. Conclusion: Results of the present research showed that A. fasciculifolius manna can prevent pain and inflammation because of the presence of high amount of saponin.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Astragalus fasciculifolius manna; antinociceptive, antiinflammatoryand antioxidant properties in mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The late phase occurs One hour after carrageenan exposure due to infiltration of polymorphonuclear (PMN) leukocytes and the formation of advanced prostaglandins (Zhang et al, 2013). Suppression of the early phase may be associated with the inhibition of the release of early mediators, such as serotonin and histamine, whereas suppression of the second phase may be attributed to the inhibition of cyclooxygenase activity (Lande et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Anti-inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol Extract

2018

J App Pharm Sci

View full text Add to dashboard Cite

Coptosapelta flavescens Korth is a liana plant of the Rubiaceae family known in East Kalimantan as Akar Tambolekar or Akar Merung. Its anti-inflammatory activity has not been scientifically proven in vitro or in vivo. The current study aimed to prove the anti-inflammatory activity of C. flavescens root (CFR) methanol extract in vitro and in vivo. The anti-inflammatory activity of CFR methanol extract was evaluated in vitro by examining its ability to stabilize the membrane of hypotonicity-induced red blood cells (RBC), and in vivo study showed the effect on carrageenaninduced inflammation on the left leg of Wistar rats following its oral administration at 1 hour before, during, and after carrageenan induction. Result of in vitro study revealed that the EC50 of CFR methanol extract was 1.905 ± 0.119 mg/ml, lower than that of indomethacin (10.288 ± 0.212 mg/ml). In vivo study showed that CFR methanol extract at doses of 600 and 1200 mg/kg administered 1 hour before and during carrageenan induction exhibited antiinflammatory activity, but only the CFR methanol extract showed anti-inflammatory activity at a dose of 1200 mg/ kg when administered 1 hour after carrageenan induction. CFR methanol extract exhibited anti-inflammatory activity both in vitro and in vivo.

show abstract

“…Due to its long use in history in traditional medicine, the Chlorophytum genus has drawn the attention of researchers in evidence-based medicine. Preparations obtained from different Chlorophytum species have been studied for their biological activity and were found to possess immunomodulatory and anti-infectious [ 11 , 12 , 13 , 14 , 15 , 16 ], antibacterial [ 17 ], antinociceptive [ 18 ] and antioxidant activities [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] to improve male sexual health [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], to ameliorate manifestations of diabetes, hyperglycemia and hyperlipidemia [ 35 , 36 , 37 , 38 ] or toxic hepatic and testicular impairments [ 20 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq

et al. 2022

View full text Add to dashboard Cite

Chlorophytum genus has been extensively studied due to its diverse biological activities. We evaluated the methanolic extract of leaves of Chlorophytum comosum (Green type) (Thunb.) Jacques, the species that is less studied compared to C. borivilianum. The aim was to identify phytoconstituents of the methanolic extract of leaves of C. comosum and biological properties of its different fractions. Water fraction was analyzed with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Nineteen compounds belonging to different chemical classes were identified in the methanolic extract of leaves of C. comosum (Green type) (Thunb.) Jacques. In addition to several fatty acids, isoprenoid and steroid compounds were found among the most abundant constituents. One of the identified compounds, 4′-methylphenyl-1C-sulfonyl-β-d-galactoside, was not detected earlier in Chlorophytum extracts. The water fraction was toxic to HeLa cells but not to Vero cells. Our data demonstrate that methanolic extract of leaves of C. comosum can be a valuable source of bioactive constituents. The water fraction of the extract exhibited promising antitumor potential based on a high ratio of HeLa vs. Vero cytotoxicity.

show abstract

Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase

Cited by 15 publications

References 19 publications

Astragalus fasciculifolius manna; antinociceptive, antiinflammatoryand antioxidant properties in mice

Astragalus fasciculifolius manna; antinociceptive, antiinflammatoryand antioxidant properties in mice

In vitro and In vivo Anti-inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol Extract

Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq

Contact Info

Product

Resources

About