Sarcoid-Like Reaction in the Spleen Following Chemotherapy for Non-Hodgkin’s Lymphoma

Reilly, Thomas B.; Schuster, David M.; Starsiak, Michael D.; Kost, Christine B.; Halkar, Raghuveer

doi:10.1097/rlu.0b013e3180646aad

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…In a few reports, however, sarcoid reactions after antineoplastic therapy have been observed only in the spleen (Reilly et al, 2007), or axial lymph nodes (Martella et al, 2012). Therefore, our study may have failed to include cases of sarcoidosis or sarcoid reactions that occurred in organs other than intrathoracic nodes.…”

Section: Discussionmentioning

confidence: 99%

FDG-PET/CT of sarcoidosis and sarcoid reactions following antineoplastic treatment

et al. 2013

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Sarcoidosis or sarcoid reactions, which appear as FDG-avid lesions in oncologic patients, need to be differentiated from disseminated malignancies. We aimed to promote awareness of development of sarcoidosis or sarcoid reactions after antineoplastic therapy to avoid diagnostic errors with FDG-PET/CT findings and assess the utility of FDG-PET/CT for follow-up. We retrospectively reviewed radiological reports of FDG-PET/CT scans performed between January 2009 and December 2011. Among oncologic patients with more than 2 FDG-PET/CT scans, those with nearly symmetrical increases in FDG uptake in the hilar or mediastinal lymph nodes were identified, and those with known sarcoidosis, concurrent diagnoses of sarcoidosis with malignancy, or histopathologically proven malignancies were excluded. Then, only those cases were selected for which sarcoidosis or sarcoid reactions were diagnosed. Four of 376 oncologic cases met the criteria. At 9 months to 6 years after antineoplastic therapy, abnormal FDG uptakes were observed in the hilar, mediastinal, abdominal, pelvic, and inguinal nodes, and/or spleen and lung parenchyma with SUVmax up to 17.7. On the basis of these findings, 1 patient received anticancer chemotherapy because of tumor recurrence suspicion. A gradual decrease in FDG uptake was observed on subsequent PET/CT scans. Sarcoidosis or sarcoid reactions should be considered in differential diagnosis of oncologic patients who have developed FDG-avid lesions any time after antineoplastic therapy. FDG-PET/CT can be used for follow-up in nondiagnostic situations to detect decreases in FDG uptake due to presence of sarcoidal granulomas.

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Section: Discussionmentioning

confidence: 99%

FDG-PET/CT of sarcoidosis and sarcoid reactions following antineoplastic treatment

et al. 2013

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“…These 2 cases show the importance of the sarcoid reaction and the importance of a pathological analysis in case of suspicion. 24 In a case report published by Han and coworkers, 25 an allergic reaction mimicked lymphoma on FDG PET/CT after contact with ginkgo nut with reactive hyperplasia on axillary lymph node. On the study of Laroche and coworkers, 4 from 1989 to 2013, 304 reports of ARRPs were identified (43.0% serious, 12 deaths) in 54.6% women and 45.4% men in France.…”

Section: Adverse Reaction To Fluorodeoxyglucose (Fdg)mentioning

confidence: 98%

“…These 2 cases show the importance of the sarcoid reaction and the importance of a pathological analysis in case of suspicion. 24…”

Section: Reviewmentioning

confidence: 99%

Adverse Reactions to Radiopharmaceuticals: A Survey Based on Clinical Cases Using Criteria of Systematic Review

Pinto

Santos

Reis

et al. 2018

Ther Innov Regul Sci

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Adverse reactions to radiopharmaceuticals are still not reported worldwide. However, the type of reaction may be severe and cause death. A review of the literature was performed using some criteria of a systematic review established by the Cochrane Collaboration. The results showed that there are a large number of adverse reactions to radiopharmaceuticals. Nuclear medicine staff must be aware of the possibility of adverse reaction with radiopharmaceuticals and find time to share this information with the radiopharmacist and the national pharmacovigilance system.

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“…6,8,9,13-15,21,23,33,45-56 , 5,7,10-12,16-20,22,24,25,27-32,34-44,59 Most often, these reactions are observed in lymph nodes draining the malignancy but can also occur in distant organs or the tumor-affected organ itself. [5][6][7][10][11][12][16][17][18][19][20]22,24,25,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]46,47,59 The mechanism for sarcoidlike reactions remains unknown. 46 Some authors have suggested a T-cell-mediated host response to soluble tumor antigens and others a reaction to tumor cell metabolites.…”

mentioning

confidence: 99%

Paraneoplastic Sarcoid-Like Reactions and the Eye

Balasubramaniam

Salomão

Davies

et al. 2015

Retina

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Sarcoid-Like Reaction in the Spleen Following Chemotherapy for Non-Hodgkin’s Lymphoma

Cited by 15 publications

References 15 publications

FDG-PET/CT of sarcoidosis and sarcoid reactions following antineoplastic treatment

FDG-PET/CT of sarcoidosis and sarcoid reactions following antineoplastic treatment

Adverse Reactions to Radiopharmaceuticals: A Survey Based on Clinical Cases Using Criteria of Systematic Review

Paraneoplastic Sarcoid-Like Reactions and the Eye

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