Sarcoidosis Diagnosed in Elderly Subjects

Chevalet, P.; Clément, Renaud; Rodat, O.; Moreau, Anne; Brisseau, Jean-Marie; Clarke, Jean-Patrick

doi:10.1378/chest.126.5.1423

Cited by 63 publications

(27 citation statements)

References 30 publications

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“…In our study, the peak occurred at 41-50 years of age in males and 41-60 years in females, with a higher proportion of women patients above the age of 70 years. Limited reports appearing to date have described sarcoidosis among elderly patients 15–17. In an earlier study, Chevalet and colleagues reviewed 30 elderly patients (21 women and 9 men) above 70 years of age (mean age, 74 years) diagnosed with sarcoidosis 15.…”

Section: Discussionmentioning

confidence: 99%

“…Limited reports appearing to date have described sarcoidosis among elderly patients 15–17. In an earlier study, Chevalet and colleagues reviewed 30 elderly patients (21 women and 9 men) above 70 years of age (mean age, 74 years) diagnosed with sarcoidosis 15. Whereas alterations in general health were the major diagnostic sign, overall prognosis was similar to that in young subjects.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Alhamad

Alanezi

Idrees

et al. 2009

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVE:Sarcoidosis is prevalent worldwide with significant heterogeneity across different ethnic groups. We aimed To describe the clinical characteristics and computed tomography findings among Arab patients with pulmonary sarcoidosis.METHODS:A retrospective study of patient demographics, symptoms, co-morbid illness, sarcoidosis stage, treatment, pulmonary function and CT results.RESULTS:Of 104 patients, most (77%) were 40 years of age or older at diagnosis, and females in this category (≥40 years) significantly outnumbered male patients (69/104 (66.3%) vs. 35/104 (33.7%), P=.003). The most common complaints were dyspnea (76%), cough (72.1%) and weight loss (32.7%). The majority of patients displayed impairment in lung function parameters at presentation. However, significant impairment in forced vital capacity, percentage predicted (FVC%) (<50%) was present in only 17% of patients. The most frequent CT finding was mediastinal lymph node enlargement in 49 patients (73.1%). Parenchymal abnormalities indicating lung fibrosis were noted in 31 patients (46.3%), and traction bronchiectasis was the most common (35.8%) fibrotic pattern detected on CT scans.CONCLUSION:At presentation, clinical manifestations of sarcoidosis among this sample of Arab patients were similar to reports from other nations. Further studies are needed to explore the effects of race and ethnicity on disease severity in the Middle East.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Alhamad

Alanezi

Idrees

et al. 2009

Annals of Saudi Medicine

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“…(1) The most common symptoms in aged patients with sarcoidosis were dyspnea, cough, and chest pain [11][12][13][14][15][16][17]. Alterations of general health (asthenia and/or anorexia and/or weight loss) were frequent [16].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Alterations of general health (asthenia and/or anorexia and/or weight loss) were frequent [16]. Comparative studies of age difference in clinical presentations showed as follows both: sarcoidosis patients, diagnosed at age over 50 years and those diagnosed below age 50 had similar presenting symptoms (respiratory symptoms) and organ involvement (lung, lymph node, and skin) [18].…”

Section: Clinical Presentationmentioning

confidence: 99%

Sarcoidosis in the aged: review and management

Tachibana

Iwai

Takemura

2010

Current Opinion in Pulmonary Medicine

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Autopsy studies revealed that both apparent and subclinical or inapparent systemic involvement of sarcoidosis might exist in aged patients with sarcoidosis. Aged sarcoidosis patients often present with unusual clinical features of sarcoidosis. Occasionally, these features resemble malignancy. New treatment with tumor necrosis factor antagonists for intractable sarcoidosis, methylphenidate hydrochloride for fatigue, and bosentan for sarcoidosis-associated pulmonary hypertension may be effective in sarcoidosis in the aged. Sarcoidosis and malignancy may coexist.

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“…This may often be nonspecific and have shared associations with more frequent diseases, resulting in a diagnosis that is delayed by months to years [7]. Occasionally, rare misleading manifestations, although within the realm of sarcoidosis manifestations, can lead to sarcoidosis being missed among the gamut of possible diagnoses by physicians inexperienced in recognising sarcoidosis, particularly in elder patients [8][9][10][11][12][13][14]. Other diagnosis problems may arise during outcome, i.e.…”

Section: Introductionmentioning

confidence: 99%

Management of sarcoidosis in clinical practice

et al. 2016

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Sarcoidosis is a systemic disease of unknown cause with very diverse presentation, outcome, severity and need for treatments. While some presentations may be very typical, for many patients, the presentation is nonspecific, with shared associations with other diseases at times being by far more frequent or misleading, which can be a cause of significant delay and often several consultations before a diagnosis of sarcoidosis can be confirmed. This is particularly the case when pulmonary manifestations are in the forefront. The diagnosis relies on three well-known criteria. In clinical practice, these criteria are not easily implemented, particularly by physicians without expertise in sarcoidosis, which can lead to a risk of either under-or over-diagnosis. Qualifying the presentation according to sarcoidosis diagnosis is essential. However, it is often not easy to classify the presentation as typical versus compatible or compatible versus inconsistent. Further investigations are needed before any other hypothesis is to be considered. It is important to detect events and to determine whether or not they are indicative of a flare of sarcoidosis. Eventually, treatment needs to be related to the correct indications. The evaluation of the efficacy and safety of treatments is crucial. To address such issues, we present five emblematic cases that illustrate this. @ERSpublications Showing emblematic cases is the best way to illustrate the multiple conditions to deal with for managing sarcoidosis http://ow.ly/10A5Yv

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Sarcoidosis Diagnosed in Elderly Subjects

Cited by 63 publications

References 30 publications

Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Sarcoidosis in the aged: review and management

Management of sarcoidosis in clinical practice

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