Sarcoidosis onset after breast cancer; a potential association

Schweitzer, M.D.; Salamó, Oriana; Holt, G.E.; Donna, Elio; Mirsaeidi, Mehdi

doi:10.1016/j.ejim.2017.08.006

Cited by 15 publications

(25 citation statements)

References 10 publications

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“…This may be an incidental finding or indicate that dysregulation of the immune system mediated by either the breast cancer or sarcoidosis lead to the granulomatous inflammation of sarcoidosis or neoplasm, respectively [3, 4, 34]. In addition, there was complete resolution of the cutaneous sarcoidal lesions following treatment of the patient's metastatic breast cancer, strengthening the correlation between both entities.…”

Section: Discussionmentioning

confidence: 96%

“…In most cases, sarcoidosis was diagnosed before the detection of an associated neoplasm. Haematological malignancies remain most strongly associated compared to solid tumours [1–3]. Brincker and Wilbek in 1974 were first to describe this association, reporting that, in patients with sarcoidosis, lymphoma occurred 11 times more frequently and lung cancer occurred three times more frequently compared with the general population [5].…”

Section: Discussionmentioning

confidence: 99%

“…Haematological malignancies, in particular lymphoproliferative disorders such as Hodgkin lymphoma, are most strongly associated with sarcoidosis compared to solid organ malignancies [2, 3]. We present a rare case of cutaneous sarcoidosis occurring in association with breast carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence?

Deen

Mellick²,

Wheller³

2018

Case Reports in Dermatological Medicine

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Sarcoidosis is a rare, chronic, multisystem disease of unknown aetiology, characterised by non-caseating epithelioid cell granulomas. Its association with internal malignancy, in particular haematological cancers has been strongly documented in the literature, while its link with solid organ malignancies is less extensively reported. We present an atypical case of cutaneous sarcoidosis occurring in association with breast cancer recurrence in a 49-year-old female. Physician recognition of this link between sarcoidosis and internal malignancy is vital because many cases of sarcoidosis in association with neoplasia present initially, or even exclusively, with cutaneous sarcoidal lesions that may precede the development of cancer by several years, or as in our case, present as a cutaneous marker of concomitant underlying malignancy. Our case highlights the importance of age-appropriate cancer screening in additional to a routine work-up for systemic sarcoidosis in a patient with cutaneous sarcoidosis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence?

Deen

Mellick²,

Wheller³

2018

Case Reports in Dermatological Medicine

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“…Schweitzer et al reported 10 such cases, where sarcoidosis was diagnosed at 61 years old females, on average 4 years after breast cancer diagnosis. The authors concluded that patients with breast cancer may be at risk for developing sarcoidosis [ 7 ]. Further, Grados et al reported 4 cases of sarcoidosis diagnosed 3 years after breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis and breast cancer: A retrospective case series

Papanikolaou

2020

Respiratory Medicine Case Reports

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Background Sarcoidosis and breast cancer co-incidence is reported in the literature in the form of case reports. Aim To describe our experience from a single large sarcoidosis clinic. Methods Retrospective chart review of 1000 sarcoidosis cases seen in our clinic from 2003 to 2008. Results 429/1000 female sarcoidosis cases were identified. Among them 20/429 had a history of sarcoidosis and breast cancer. In 12/20 breast cancer preceded sarcoidosis by 52 months, in 4/20 sarcoidosis preceded breast cancer by 200 months and in 4/20 they presented concurrently. Mean age of sarcoidosis diagnosis was 53.9 (±12.4) years. Majority were of European decent (16/20), 3 were African-Americans and 1 Asian. Scadding radiography stages distribution was (n) 4/11/3/2/0 for stages 0/I/II/III/IV respectively. They had 3.4 (±1.3) organs involved, mainly with intrathoracic involvement. 10/20 were asymptomatic and 11/20 received chronic treatment. Compared to 409 cases of sarcoidosis sine breast cancer (mean age 46.7 ± 13.1), sarcoidosis-breast cancer cases had sarcoidosis diagnosed at a significantly later age (p = 0.01). Histological diagnosis applied in all co-incidence cases, in 5 via mediastinoscopy. Conclusions Older females with breast cancer may develop sarcoidosis, with features indistinguishable from stand-alone sarcoidosis. When sarcoidosis is suspected histological diagnosis is mandatory.

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“…[1][2][3] It has been proposed that breast cancer may constitute a risk or triggering factor for developing sarcoidosis which most commonly occurs in the thorax or lymph nodes, whereas hepatosplenic manifestation is infrequent. 1,2 In a sarcoidosis registry, 18% of patients had a history of breast cancer, however, this potential association remains still unproven. 2 Interestingly, the mean age of sarcoidosis onset after breast cancer is 61 years which is much higher than that of the regular population with no cancer history.…”

mentioning

confidence: 99%