Sarcoma in Pagetʼs Disease of Bone in Australia

Barry, Hugh C.

doi:10.2106/00004623-196143080-00005

Cited by 47 publications

(10 citation statements)

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“…Although the difference did not reach statistical difference (probably do to the limited number of cases, 15 men and 3 women, in fact the power associated was 30.4%), we cannot exclude that males affected by Paget's disease are more sensitive to sarcomatous degeneration, as already reported [27,28]. Histological analysis of degenerate cases revealed that almost all the sarcomas were osteosarcoma (88.9%); again, this finding is in agreement with data reported in the literature [3,4,7,19,[29][30][31].…”

Section: Discussionsupporting

confidence: 88%

“…This percentage is actually much higher than others reported in the literature; in fact, the rates of other published series vary [1,2,4,30,32]. The high difference with respect to the previously reported rates can be accounted for the different ways of enrolment; for example, we analysed only patients who had been admitted to hospital, excluding patients who were merely receiving outpatient follow-up.…”

Section: Discussionmentioning

confidence: 63%

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Degeneration of Paget’s disease into sarcoma: clinical and therapeutic influencing factors

Zati

Bilotta

2008

Chir Organi Mov

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We analysed a series of 119 patients presenting with Paget's bone disease treated at the Istituto Ortopedico Rizzoli (Bologna Italy) over 35 years (from 1970 to 2006). Among these, we found 18 cases that had degenerated into sarcoma. The first goal of this study was to underline the potential factors of Paget's disease transformation into sarcoma. In detail we considered: age, gender, duration of disease, clinical expression, levels of total alkaline phosphatase and type of therapy. The results highlighted an interesting correlation between therapy and degeneration into sarcoma; more specifically, malignant transformation occurred both in patients who had not received any therapy and those who had received regular calcitonin treatment; otherwise, no sarcoma degeneration occurred in the patients treated with bisphosphonates. These data seem to indicate a preventing effect of bisphosphonates towards the degeneration of Paget's disease into sarcoma.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 63%

Degeneration of Paget’s disease into sarcoma: clinical and therapeutic influencing factors

Zati

Bilotta

2008

Chir Organi Mov

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“…10 A larger proportion (one third) of the rare cases that occur in children and adolescents are secondary. 11,12 Chondrosarcoma has been reported to develop concurrently with osteosarcoma 13 and in association with other benign conditions, including Paget's disease 14 and fibrous dysplasia.…”

mentioning

confidence: 99%

National cancer database report on chondrosarcoma of the head and neck

et al. 2000

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“…Since then, including our 2 cases, 59 patients in 24 families have been reported (Barry 1961;Bech-Hansen et al 1981;Bottomley et al 1971;Brenton et al 1980;Colyer 1979;Epstein et al 1970;Gilman et al 1985;Harmon and Morton 1966;Lee and Mackenzie 1964;Matejovsky 1977;McIntyre et al 1994;Miller and McLaughlin 1977;Miller 1968;Mulvihill et al 1977;Nassar and Gravanis 1981;Nishida et al 1994;Pohle et al 1936;Robbins 1967;Roberts and Roberts 1935;Salvati et al 1994;Schimke et al 1974;Smith et al 1980;Swaney 1973;Werner 1930). The authors collected data from 59 cases, including the age and sex of the patient, the anatomical site, and previous disorders, treatment, and prognosis.…”

Section: Discussionmentioning

confidence: 99%