Sarcomatoid carcinoma of pancreas with liver metastases – A case report with review of literature

K, Rakul Nambiar; Roshni, S; Lijeesh, Attokaran L; Mony, Rari P.

doi:10.15761/jmt.1000112

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…Sarcomatoid carcinoma primarily occurs in the lungs, esophagus, breast, larynx, and genitourinary tract [2,3]. Sarcomatoid carcinoma of the pancreas (SCP) is extremely rare, and only a small number of cases have been reported in the English literature [2][3][4][5][6][7][8][9][10][11][12]. Sarcomatoid carcinoma is generally thought to represent a process of epithelial-mesenchymal transition (EMT) of an epithelial tumor, and EMT is a plausible mechanism of tumorigenesis of SCP [3,11].…”

Section: Introductionmentioning

confidence: 99%

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Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report

et al. 2020

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Background Sarcomatoid carcinoma of the pancreas (SCP) tends to have similar or even worse prognosis than that of conventional pancreatic ductal adenocarcinoma. The clinical and pathological features of SCP remain poorly characterized owing to its rarity. Case presentation A 58-year-old man was admitted to our hospital with the chief complaints of upper abdominal pain and weight loss. Abdominal contrast computed tomography revealed a 5-cm low-density mass in the pancreatic body. Magnetic resonance cholangiopancreatography revealed an obstruction of the main pancreatic duct and a dilation of the distal main pancreatic duct. Based on the clinicoradiological findings, pancreatic body cancer was suspected, and the distal pancreatectomy was performed. A pathological examination revealed that the tumor was composed of an area of invasive ductal adenocarcinoma and an area of sarcomatous spindle-shaped cells; the latter component predominated. The spindle cells were immunohistochemically positive for both cytokeratin and vimentin, and thus, a pathological diagnosis of SCP was made. In addition, immunohistochemical analysis suggested the sarcomatous component might be derived from the adenocarcinoma component via the process of epithelial-mesenchymal transition. After the operation, the patient received 6 months of chemotherapy with gemcitabine. At 10 years after the operation, the patient is alive with no recurrence. Conclusions The current case study presented a SCP patient with long-term survival after the operation. It was worth noting that the sarcomatous component of the tumor pathologically showed lower MIB-1 labeling index compared with those in previously reported SCP cases, which might account for the long-term survival of the patient.

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Section: Introductionmentioning

confidence: 99%

“…The prognosis of SCP tends to be similar to or even worse than that of conventional pancreatic ductal adenocarcinoma [2][3][4][5][6][7][8][9][10][11][12]. Herein, we report a rare case of SCP with long-term survival after the operation.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report

et al. 2020

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“…Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis [ 1 , 2 ]. The survival benefit of surgery for SCP remains uncertain, and no therapeutic strategies for SCP have been established.…”

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confidence: 99%

Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

et al. 2021

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Aim Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. Findings The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.

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“…In addition to this patient, 10 cases of pancreatic sarcomatoid carcinoma with confirmed epithelial derivation of the spindle component and/or absence of specific mesenchymal differentiation have been reported [5–14]. Of the previously reported patients (Table 1) our case is the first T2N0M0 ASCP case reported.…”

Section: Discussionmentioning

confidence: 71%

“…The longest survival reported was 26 months, documented in an 85-year-old male who underwent distal (near-total) pancreatectomy, splenectomy and partial gastrectomy. Three patients had liver metastasis on presentation [14].…”

Section: Discussionmentioning

confidence: 99%

Early Stage Anaplastic Sarcomatoid Carcinoma of The Pancreas, A Case Report

Bukhari

Joudeh

2019

Am J Case Rep

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Patient: Male, 64 Final Diagnosis: Anaplastic sarcomatoid carcinoma of the pancreas Symptoms: Abdominal pain Medication: — Clinical Procedure: Pancreatoduodenectomy Specialty: Oncology Objective: Rare disease Background: Anaplastic sarcomatoid carcinoma of the pancreas (ASCP) is a rare variant of pancreatic malignancies. It is a high-grade epithelial carcinoma predominated with spindle cells. Case Report: We report a case of a 65-year-old patient who presented with early stage, ampullary mass indicating malignancy, and who subsequently underwent pancreatoduodenectomy. Histopathology and immunohistochemistry were confirmatory for anaplastic, grade IV sarcomatoid adenocarcinoma arising from the head of the pancreas. Conclusions: To our knowledge, this is a rare presentation with few cases reported in the literature.

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Sarcomatoid carcinoma of pancreas with liver metastases – A case report with review of literature

Cited by 5 publications

References 8 publications

Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report

Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report

Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

Early Stage Anaplastic Sarcomatoid Carcinoma of The Pancreas, A Case Report

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