Sarcopenia and consumptive syndrome in HIV-infected patients receiving antiretroviral therapy in a public hospital in Northeast Brazil

Nascimento, Luciano; Santos, Eryka Maria dos; Silva, Lídia Laís Gomes; Pinho, Cláudia Porto Sabino

doi:10.4067/s0717-75182020000300430

Cited by 1 publication

(6 citation statements)

References 51 publications

(67 reference statements)

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“…Furthermore, a cross‐sectional study of 44 HIV‐infected subjects with sarcopenia incidence of 25% showed that the presence of sarcopenia had a significant correlation with the CD4 cell count 18 . A similar finding was reported in a cross‐sectional study conducted among 99 HIV+ individuals with a mean age of 41 ± 11 years and sarcopenia and pre‐sarcopenia incidence of 18.2% and 16%, respectively 21 …”

Section: Resultssupporting

confidence: 77%

“…In fact, elderly patients diagnosed with type 2 diabetes had a 30% greater 3‐year decline in muscle strength. Additionally, a higher baseline CD4 + T‐cell count was associated with a greater incidence of sarcopenia 21 . To support this, a study indicated that weight and BMI were significantly lower when there were lower levels of CD4 + T cells and the greatest weight loss occurred when CD4 + T cells counts were lower than 600 cells per millilitre.…”

Section: Resultsmentioning

confidence: 99%

“…mean age of 41 ± 11 years and sarcopenia and pre-sarcopenia incidence of 18.2% and 16%, respectively. 21 Viral load of 57% of HIV infected individuals was undetectable and they were receiving ART for 48 months. Also, sarcopenia was significantly higher in those who were ˃65 years old, had diabetes mellitus and were malnourished.…”

Section: Sarcopenia Prevalence and Associated Factorsmentioning

confidence: 99%

“…Additionally, a higher baseline CD4 + T-cell count was associated with a greater incidence of sarcopenia. 21 To support this, a study indicated that weight and BMI were significantly lower when there were lower levels of CD4 + T cells and the greatest weight loss occurred when CD4 + T cells counts were lower than 600 cells per millilitre. Low muscle strength was reported as a significant factor of sarcopenia in a study which was conducted among 302 HIV+ individuals with a sarcopenia incidence rate of 4.3%, mean CD4 + count of 173, and 75.1% undetectable viral load.…”

Section: Sarcopenia Prevalence and Associated Factorsmentioning

confidence: 99%

“…The most common utilized criteria were the European Working Group on Sarcopenia in Older People (EWGSOP), which was used by seven articles. [18][19][20][21][22][23][24] The next common method was the measurement of appendicular skeletal muscle mass index (ASMI), which was used by three papers. 14,16,17 Finally, the Asian Working Group for Sarcopenia (AWGS), percentage skeletal muscle mass (PSMM) and Sarcopenia Definitions and Outcomes Consortium (SDOC) methods were each used by one included study.…”

Section: Description Of the Included Studiesmentioning

confidence: 99%

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A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus

SeyedAlinaghi

Ghayomzadeh

Mirzapour

et al. 2023

J cachexia sarcopenia muscle

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People living with human immunodeficiency virus (HIV) (PLWH) appear to be at an increased risk of sarcopenia, which can have a devastating effect on their life due to consequences such as physical disability, poor quality of life, and finally death. This systematic review examined sarcopenia prevalence and its associated factors in PLWH. A systematic search was conducted using the keywords in the online databases including Scopus, PubMed, Web of Science, Embase and Cochrane databases from the dates of inception up to May 2022. The retrieved articles underwent a two-step title/abstract and full-text review process, and the eligible papers were selected and included in the qualitative synthesis. Data relating to the study population, purpose of study, gender, age, race, body mass index, medical history, paraclinical results and antiretroviral therapy as associated factors of sarcopenia were extracted. In addition, the prevalence of sarcopenia in PLWH and its promoting and reducing factors were also extracted. We reviewed the 14 related studies for identifying of sarcopenia prevalence and its associated factors in PLWH. The total number of PLWH in all the reviewed studies was 2592. There was no criterion for the minimum number of people with HIV and the lowest number of PLWH was 27, and the highest number was 860. Some studies reported a significantly higher prevalence of sarcopenia in HIV-infected individuals compared with HIV-negative controls as follows: 24.2-6.7%, 15-4% and 10-6%, respectively. We showed that, age (30-50 years), being female, >5 years post-HIV diagnosis, multiple vertebral fractures, cocaine/heroin use and lower gamma-glutamyl transferase level were the main promoting factors of sarcopenia. Higher educational level, employment, physical exercise, calf circumference >31 cm, and gait speed >0.8 m/s were also factors to reduce sarcopenia. Sarcopenia prevalence in PLWH is higher than HIV-negative population. Given the importance and prevalence of sarcopenia among PLWH and its associated consequences (i.e., mortality and disability), determining its risk factors is of great importance.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Sarcopenia Prevalence and Associated Factorsmentioning

confidence: 99%

Section: Sarcopenia Prevalence and Associated Factorsmentioning

confidence: 99%