Sarcopenia and Endocrine Ageing: Are They Related?

Gupta, Prishita; Kumar, Sunil

doi:10.7759/cureus.28787

Cited by 6 publications

(4 citation statements)

References 74 publications

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“…Endocrine function declines with age because many hormones decrease with age and hormone receptors become less sensitive. A decrease in hormones important for muscle maintenance such as insulin-like growth factor-1 (IGF-1), testosterone, estrogen and dehydroepiandrosterone (DHEA) contributes to sarcopenia (19). In our study, one third of the control group was sarcopenic, which is a signi cant proportion.…”

Section: Discussionmentioning

confidence: 60%

Life Activities of Elderly Patients With Operated Nonfunctional Pituitary Adenoma

kara,

Avcı,

Melikoglu

et al. 2023

Preprint

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Aim To evaluate the clinical findings of nonfunctional pituitary adenomas (NFA) in the geriatric population, functional status, cognitive function, quality of life and frailty. Material-Method We evaluated operated NFA cases aged 65 years and older followed up in our clinic between 2010 and 2022. Patients seen in the geriatric outpatient clinic with a diagnosis of hypertension and diabetes mellitus were included in the study as a control group. Bioimpedance was used to assess muscle strength, walking speed, and muscle to fat ratio in patients. In addition, quality of life, anxiety, depression, cognitive function, and frailty were assessed. Results The study included 43 patients with NFA and 60 patients with hypertension (HT) and type 2 diabetes mellitus (DM) diagnoses. The mean age, sex ratios and body mass index (BMI) of the patients with NFA and the control group diagnosed with HT and type 2 DM were similar (age: 70.9±0.66; 73.1±0.8 (p=0,6), FM /M: 24/19, 35/25 (p=0.1) and BMI:28.3±3.9/28.5±4.8 (p=0.9), respectively). Cognition status (MMT: 28;29, p=0.002), frailty scores (2[2-3]; 1[1-2], M[IQR], p<0.001), sarcopenia rates (62%; 30%, p=0.007) was worse in patients with NFA. Conclusion In the study comparing patients diagnosed with surgical pituitary NFA with patients of similar age and comorbidity, the frailty score and rate of sarcopenia were higher and their cognition was worse. Complications arising from surgical and postoperative treatment of patients with pituitary NFA make geriatric patients more frail. We emphasize that patients with NFA in this age group should be examined more carefully.

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Section: Discussionmentioning

confidence: 60%

Life Activities of Elderly Patients With Operated Nonfunctional Pituitary Adenoma

kara,

Avcı,

Melikoglu

et al. 2023

Preprint

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“…history of hypothalamic/pituitary disorders, surgery and/or cranial irradiation to this region in the brain), and with the aim to offer treatment when the diagnosis is confirmed [70][71][72]. However, the clinical benefit of initiating GH therapy in older patients is a matter of debate [73]. Moreover, cut-off values could be different, as reported by Colao et al [74], which found that individuals older than 65 yr have lower cut-off points than do middle-aged adults.…”

Section: Somatotropic Axis Pathology and Treatment In Agingmentioning

confidence: 99%

Age-Related Hormones Changes and Its Impact on Health Status and Lifespan

Biagetti¹,

Puig‐Domingo²

2023

Aging and disease

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The increase in life expectancy is accompanied with an increased consultation of age-related pathologies including endocrine disorders. Two main areas are focusing the attention of medical and social research in older population: the diagnosis and care of this heterogeneous population, and the interventional measures potentially useful to mitigate age-related functional declines and to increase health and quality of lifespan. Thus, better understanding the physiopathology of aging and establishing accurate diagnostic and personalized approaches are a priority and currently an unmet need of the medical community. The endocrine system plays a major role in survival and lifespan through regulating vital processes such as energy consumption and optimizing the stress response among others. The aim of this paper is to review the physiological evolution of the main hormonal functions in aging and its clinical translation to improve our approach to the aging patient.

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“…Some hormones are integral for the growth and maintenance of skeletal muscle, including insulin-like growth factor-1, dehydroepiandrosterone, testosterone and oestrogen, all of which decrease with increasing age [106] and may contribute to sarcopenia and frailty [107]. Men with low free testosterone are 68% more likely to develop mobility limitation than men with normal free testosterone [108].…”

Section: Hormone Replacementmentioning

confidence: 99%

Old muscle, new tricks: a clinician perspective on sarcopenia and where to next

Schütze,

Schopp,

Fairchild

et al. 2023

Current Opinion in Neurology

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Purpose of review This review offers a contemporary clinical approach to the recognition, prevention and management of sarcopenia, and discusses recent clinically relevant advances in the aetiopathogenesis of muscle ageing that may lead to future therapeutic targets. Recent findings The key recent directions for sarcopenia are in the diagnosis, understanding molecular mechanisms and management. Regarding the recognition of the condition, it has become increasingly clear that different definitions hamper progress in understanding. Therefore, the Global Leadership in Sarcopenia has been established in 2022 to develop a universally accepted definition. Moreover, substantial work is occurring to understand the various roles and contribution of inflammation, oxidative stress, mitochondrial dysfunction and metabolic dysregulation on skeletal muscle function and ageing. Finally, the role of resistance-based exercise regimes has been continually emphasised. However, the role of protein supplementation and hormone replacement therapy (HRT) are still under debate, and current clinical trials are underway. Summary With the global ageing of our population, there is increasing emphasis on maintaining good health. Maintenance of skeletal muscle strength and function are key to preventing frailty, morbidity and death.

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Sarcopenia and Endocrine Ageing: Are They Related?

Cited by 6 publications

References 74 publications

Life Activities of Elderly Patients With Operated Nonfunctional Pituitary Adenoma

Life Activities of Elderly Patients With Operated Nonfunctional Pituitary Adenoma

Age-Related Hormones Changes and Its Impact on Health Status and Lifespan

Old muscle, new tricks: a clinician perspective on sarcopenia and where to next

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