Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study

Landi, Francesco; Liperoti, Rosa; Russo, Andrea M.; Giovannini, Silvia; Tosato, Matteo; Capoluongo, Ettore; Bernabei, Roberto; Onder, Graziano

doi:10.1016/j.clnu.2012.02.007

Cited by 764 publications

(556 citation statements)

References 36 publications

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“…This is consistent with the information reported by previous studies who documented the association between underweight and sarcopenia [4] [8] [25].…”

Section: Discussionsupporting

confidence: 83%

“…Previous studies [4] [26] [27] and the current study found a significant association between physical activity and sarcopenia (p = 0.002). Lack of physical activity has been shown to be a risk factor for muscle weakness that, in turn, results in loss of muscle mass and muscle strength [26] [27].…”

Section: Discussionmentioning

confidence: 63%

“…It is a syndrome characterized by progressive and generalized loss of skeletal muscle mass, strength, and muscle function [1]. Sarcopenia is associated with weakness, loss of independence, disability, higher risk of falls, and a decrease in quality of life [2]- [4]. The significant clinical impact of sarcopenia and its high costs both direct and indirect that this condition generates emphasizes the need of health care systems to focus on this geriatric syndrome [5]- [7].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Sarcopenia among Nursing Home Older Residents in Cairo, Egypt

Rahman¹,

Elkholy²,

Mortagy³

2014

AAR

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Sarcopenia is highly prevalent in community dwelling older adults in many countries; however, the prevalence of sarcopenia in nursing home older residents is not well characterized. The aim of this study is to assess the prevalence of sarcopenia in nursing home older residents in Cairo. Cross sectional study was performed among 357 nursing home residents in Cairo. The European Working Group on Sarcopenia in Older People (EWGSOP) recommendation was used for diagnosing sarcopenia. The study showed that the prevalence of sarcopenia in nursing home older residents in Cairo was 17.7%, 22.2% in elderly men and 14.4% in elderly women. Age, underweight and lack of physical activity were found to be associated with sarcopenia among studied participants. The study concluded that sarcopenia is an emerging health problem in nursing home older residents in Cairo.

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“…This is consistent with the information reported by previous studies who documented the association between underweight and sarcopenia [4] [8] [25].…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Sarcopenia among Nursing Home Older Residents in Cairo, Egypt

Rahman¹,

Elkholy²,

Mortagy³

2014

AAR

View full text Add to dashboard Cite

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“…For instance, the conversion of type II (fast) fibers to type I (slow) fibers and subsequent lipid infiltration, which translate into impairment of muscle power and a greatly increased risk of falls [4]. Several studies have shown that sarcopenic individuals are either three times more likely to fall or have an higher risk of death relative to non sarcopenic individuals [5], [6]. Moreover, sarcopenia itself is associated with disability and hospitalization [7].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and sarcopenia: A systematic review and meta-analysis

et al. 2017

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Nicola.Inflammation and sarcopenia: A systematic review and meta-analysis.Maturitas http://dx.doi.org/10.1016/j.maturitas. 2016.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights Sarcopenia is associated with functional impairment and adverse outcomes.  Highly inflammatory cytokines are negatively related to muscle strength and mass.  Sarcopenia is associated with higher serum inflammatory parameters.  Chronic inflammation could play a role in sarcopenia. AbstractInflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size. Out of 1370 initial hits, 17 studies with a total of 11249 participants (3072 with sarcopenia and 8177 without) were meta-analysed. Sarcopenic participants had significantly higher levels of CRP (SMD=0.51; 95%CI 0.26, 0.77; p<0.0001; I 2 =96%) than controls. Conversely, serum IL6 levels were not significantly different (SMD=0.35; 95%CI: -0.19, 0.89; p=0.21; I 2 =97%) in people with sarcopenia versus controls. Sarcopenic people did not have higher levels of TNF-than controls (SMD=0.28; 95%CI -0.26, 0.83; p=0.31; I 2 =97%). In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship.

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“…Aging-related changes in body composition are reported to be negative, with the levels of body fat increasing constantly and the muscle mass and strength decreasing 4) . These changes lead to various physical and physiological changes, and also affect physical function and the risk of various diseases [5][6][7][8][9][10] . In terms of the reduction of muscle mass due to aging, the reduction to an extent that it leads to limited muscle strength or performance of physical activities is referred to as 'sarcopenia,' which has various negative effects on the health of the elderly.…”

Section: Introductionmentioning

confidence: 99%

A Hospital-Based Prospective Cohort Study of Aged People to Elucidate the Predictive Factors for Chronic Disease and Mortality: HAPPY Cohort

Kim

Jang

et al. 2017

Ann Geriatr Med Res

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Background: The world over, the multimorbidity associated with aging is proving to be a great socio-economic burden. The loss of muscle mass and increased adiposity are typical of aging, but the number of longitudinal studies focusing on sarcopenia or sarcopenic obesity is currently limited. We launched a hospital-based, prospective cohort study of aged people (HAPPY cohort) to identify the impact of sarcopenia or sarcopenic obesity on the occurrence of chronic diseases including diabetes, or its vascular complications, osteoporosis and fractures, cognitive dysfunction, and mortality. Methods: For the HAPPY cohort, we aim to recruit 1,000 patients, aged 60 years and above, who visit a tertiary hospital from August 2015. Participants are scheduled to undergo repeated waves of assessment every 3 years; this will be done for 9 years or until death. Results: General information and medical histories are collected through personal interviews and validated using medical records. Participants' physical function is assessed by diverse functional assessments including the hand grip strength test, timed up and go test, and the chair rise test. The functional status, nutritional status, levels of depression, and cognitive function of the participants are also measured. The body compositions are assessed using dual energy X-ray absorptiometry and the bioelectrical impedance method. The biochemical parameters related with chronic diseases are measured. Conclusion: This HAPPY cohort study will provide results relevant to the many health issues among elderly Asians (among at least elderly Koreans). These results will help us gain a better understanding of sarcopenia and sarcopenic obesity, as well as the cross-sectional and longitudinal association of chronic diseases and mortality among elderly adults.

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Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study

Cited by 764 publications

References 36 publications

Prevalence of Sarcopenia among Nursing Home Older Residents in Cairo, Egypt

Prevalence of Sarcopenia among Nursing Home Older Residents in Cairo, Egypt

Inflammation and sarcopenia: A systematic review and meta-analysis

A Hospital-Based Prospective Cohort Study of Aged People to Elucidate the Predictive Factors for Chronic Disease and Mortality: HAPPY Cohort

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