Sarcopenia as a Risk Factor for Cognitive Deterioration in Community-Dwelling Older Adults: A 1-Year Prospective Study

Nishiguchi, Shu; Yamada, Minoru; Shirooka, Hidehiko; Nozaki, Yuma; Fukutani, Naoto; Tashiro, Yuto; Hirata, Hinako; Yamaguchi, Moe; Tasaka, Seishiro; Matsushita, Takatoshi; Matsubara, Keisuke; Tsuboyama, Tadao; Aoyama, Tomoki

doi:10.1016/j.jamda.2015.12.096

Cited by 56 publications

(62 citation statements)

References 20 publications

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“…In a 1 year follow up of 131 Japanese elderly subjects, sarcopenia was associated with a larger decline in MMSE scores. 18 However, the longitudinal EPIDOS-Toulouse study reported that decreased muscle mass and walking speeds were not associated with cognitive decline in 181 elderly women. 19 These findings suggest that differences in the methods used to evaluate sarcopenia, the definition of sarcopenia, and the studied population could underlie the inter-study inconsistency.…”

Section: Discussionmentioning

confidence: 99%

“…However, studies of the association between sarcopenia and dementia are inconclusive. [15][16][17][18][19] In a large cohort of 7105 elderly women, body composition, low fat mass, and low fat-free soft mass were significantly associated with cognitive impairment after adjustment for multiple possible confounding variables. 15 In the EIDOS cohort, cognitive impairment was significantly associated with slow walking speed and low hand grip strength, but sarcopenic parameters obtained from dual-energy X-ray absorptiometry were not related to cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…However, results from studies that have evaluated the association between sarcopenia and cognitive impairment in a general population are inconclusive. [15][16][17][18][19] Furthermore, no studies have evaluated the underling mechanisms linking sarcopenia and cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

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Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study

Kohara

Okada

Ochi

et al. 2017

J cachexia sarcopenia muscle

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BackgroundThere is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross‐sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association.MethodsTwo sarcopenic indices were measured: thigh muscle cross‐sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance). Muscle mass decline was defined as either the bottom 10% or 20% of participants for each sex. Cognitive function was assessed using the Touch Panel‐type Dementia Assessment Scale, and brachial–ankle pulse wave velocity was measured as an index of arterial stiffness.ResultsBoth sarcopenic indices were modestly but significantly associated with brachial–ankle pulse wave velocity in male and female subjects. The presence of WMHs was significantly associated with low thigh muscle CSA in men and with low skeletal muscle mass in women. The Touch Panel‐type Dementia Assessment Scale score was modestly but significantly and positively associated with thigh muscle CSA in men and skeletal muscle mass in women. Muscle mass decline in the bottom 10% of participants on both sarcopenic indices was significantly and independently related to cognitive impairment in women.ConclusionsLower sarcopenic indices are significantly related to lower cognitive scores. Arterial stiffness and WMHs could account, at least in part, for this association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study

Kohara

Okada

Ochi

et al. 2017

J cachexia sarcopenia muscle

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“…Although activities of daily living were maintained in the enrolled patients, respiratory function (%PEF) decline is thought to be another risk factor. Indeed, it has been reported that motor function decline and sarcopenia are risk factors for delirium in older adults . In our study, we investigated postoperative delirium using only age and %PEF, and patients positive for both factors (cut‐off value for %PEF ≤ 63.3% [AUROC 0.697]; cut‐off value for age, ≥ 73 years old [AUROC 0.734]) were considered to be in the high‐risk group for postoperative delirium.…”

Section: Discussionmentioning

confidence: 99%

Impact of muscle volume and muscle function decline in patients undergoing surgical resection for hepatocellular carcinoma

Hiraoka

Otsuka

Kawasaki

et al. 2018

J of Gastro and Hepatol

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“…32 A prevalência da sarcopenia segundo uma recente revisão sistemática realizada por Cruz-Jentoft et al 33 pode variar de 1% a 29% entre idosos que residem na comunidade. Ela tem sido associada com anorexia e quedas 19 e declínio cognitivo 34 .…”

Section: Discussionunclassified

Estado nutricional de idosos residentes nos municípios da Superintendência Regional de Saúde de Uberaba

Damião

Meneguci

Santos

et al. 2019

Rev. Med. (São Paulo)

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Objetivo: avaliar o estado nutricional de idosos residentes nos municípios da Superintendência Regional de Saúde de Uberaba. Material e Métodos: Estudo transversal, realizado com indivíduos com ≥ 60 anos de idade, residentes em Minas Gerais, Brasil. O estado nutricional foi avaliado pela Mini Avaliação Nutricional (MAN). Calcularam-se as distribuições de frequências relativas e absolutas das variáveis estudadas. As diferenças encontradas entre as prevalências do estado nutricional e os componentes da MAN segundo sexo, foram testadas utilizando-se a estatística do qui-quadrado. Resultados: Foram analisados 3.101 idosos. A prevalência de desnutrição entre os idosos foi de 1,7% e, 27,8% de risco de desnutrição. Observou-se diferenças estatisticamente significantes no estado nutricional entre os sexos, principalmente em relação ao risco de desnutrição, sendo 24,4% nos homens e 29,9% nas mulheres. Nos parâmetros de diagnóstico do estado nutricional entre os idosos desnutridos e aqueles em risco de desnutrição, a redução do perímetro da panturrilha, perda de peso, diminuição da ingestão alimentar e o não consumo de frutas e vegetais apresentaram maiores percentuais. Os idosos desnutridos, em ambos os sexos, apresentaram piores parâmetros antropométricos, de saúde, alimentares e de auto avaliação na percepção da saúde e do estado nutricional quando comparados com idosos sob risco de desnutrição. Conclusão: O elevado déficit do estado nutricional, desnutrição e risco de desnutrição, observado nos idosos residentes na comunidade dos municípios avaliados demonstra um problema de saúde pública. Espera-se que os achados desse estudo chamem a atenção de setores que trabalham com a integralidade da saúde dos idosos.

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Sarcopenia as a Risk Factor for Cognitive Deterioration in Community-Dwelling Older Adults: A 1-Year Prospective Study

Cited by 56 publications

References 20 publications

Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study

Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study

Impact of muscle volume and muscle function decline in patients undergoing surgical resection for hepatocellular carcinoma

Estado nutricional de idosos residentes nos municípios da Superintendência Regional de Saúde de Uberaba

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