Sarcopenia as a Risk Factor for Future Hip Fracture: A Meta-Analysis of Prospective Cohort Studies

Huang, Pan; Luo, Kai; Xu, Jiachen; H, Wu; Wu, Yin; Xiao, Man; Wang, Y.; Ding, Mei; Huang, Xiaofeng

doi:10.1007/s12603-020-1474-5

Cited by 22 publications

(19 citation statements)

References 39 publications

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“…With the increasing numbers of older adults, health-related problems resulting from body composition changes are also increasing. A loss of muscle mass, muscle strength, and/or reduced physical performance, called sarcopenia, is related to the risk of frailty and its related complications, such as falls and fractures [6][7][8]. Moreover, an increase in fat mass, the central redistribution of fat, and obesity contribute to the risk of metabolic disorders such as hypertension, type 2 diabetes mellitus, and cardiovascular disease [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Using Dietary Macronutrient Patterns to Predict Sarcopenic Obesity in Older Adults: A Representative Korean Nationwide Population-Based Study

2021

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Older adults with sarcopenic obesity (SO) are at increased risk of adverse health outcomes. It has not been identified which pattern of macronutrient intake is appropriate in relation to SO. We aimed to compare the patterns of macronutrient intake for predicting SO in older adults. Data from a total of 3828 older adults who participated in the 2008–2011 Korea National Health and Nutrition Examination Survey were analyzed. The one-day 24 h dietary recall method was used to assess macronutrient intake. SO was defined by a combination of body mass index (BMI) ≥ 25 kg/m2 and BMI adjusted-appendicular skeletal muscle mass <0.789 for men and <0.512 for women. Weighted logistic regression analysis revealed the odds ratio (95% confidence interval) for SO of total calorie intake per 100 increments and carbohydrate (CHO) intake (g/kg/day) per 1 increment to be 0.95 (0.91–0.99) and 0.83 (0.74–0.94), respectively, after adjusting for confounding variables in women. The predictive power for SO of CHO intake (g/kg/day) was higher compared with the other patterns of macronutrient intake both in men and women. In conclusion, total calorie intake and CHO intake (g/kg/day) are inversely related to SO in women. CHO intake (g/kg/day) could be the best index for determining SO.

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Section: Introductionmentioning

confidence: 99%

Using Dietary Macronutrient Patterns to Predict Sarcopenic Obesity in Older Adults: A Representative Korean Nationwide Population-Based Study

2021

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“…It is widely described in the literature that malnutrition is highly prevalent and a strong predictor of worse clinical outcomes in hospitalized patients [ 9 ]. Sarcopenia is also a condition recognized for increasing the risk of worse clinical outcomes, with a large literature available, especially in non-hospitalized individuals (with impairment of daily activities and instrumental activities of daily living, risk of hip fracture, and mortality) [ 10 , 11 , 12 ]. Some studies conducted in hospitalized patients have demonstrated poorer mobility, low quality of life, increased length of hospital stay, post-surgical complications, and mortality in patients with sarcopenia, compared to those without it [ 1 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Isolated Sarcopenia or Malnutrition–Sarcopenia Syndrome for Clinical Outcomes in Hospitalized Patients

Sousa

Burgel

Silva³

et al. 2022

Nutrients

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Malnutrition–sarcopenia syndrome (MSS) is frequent in the hospital setting. However, data on the predictive validity of sarcopenia and MSS are scarce. We evaluated the association between sarcopenia and MSS and clinical adverse outcomes (prolonged length of hospital stay—LOS, six-month readmission, and death) using a prospective cohort study involving adult hospitalized patients (n = 550, 55.3 ± 14.9 years, 53.1% males). Sarcopenia was diagnosed according to the EWGSOP2, and malnutrition according to the Subjective Global Assessment (SGA). Around 34% were malnourished, 7% probable sarcopenic, 15% sarcopenic, and 2.5% severe sarcopenic. In-hospital death occurred in 12 patients, and the median LOS was 10.0 days. Within six months from discharge, 7.9% of patients died, and 33.8% were readmitted to the hospital. Probable sarcopenia/sarcopenia had increased 3.95 times (95% CI 1.11–13.91) the risk of in-hospital death and in 3.25 times (95% CI 1.56–6.62) the chance of mortality in six months. MSS had increased the odds of prolonged LOS (OR = 2.73; 95% CI 1.42–5.25), readmission (OR = 7.64; 95% CI 3.06–19.06), and death (OR = 1.15; 95% CI 1.08–1.21) within six months after discharge. Sarcopenia and MSS were predictors of worse clinical outcomes in hospitalized patients.

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“…Sarcopenia has been identified as an independent risk factor for many factors and is significantly associated with the mortality of older people, especially individuals with musculoskeletal disorders ( 10 , 11 ). In recent years, more and more studies suggested that sarcopenia played a significant role in not only the incidence of osteoporosis and hip fracture but also the prognosis after hip surgeries ( 12 , 13 ). Moreover, it is also reported that older patients who underwent surgeries for hip fractures may have an increased risk of sarcopenia, which may be caused by poor mobility and a long stay in bed after surgery ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Mapping knowledge structure and global status of sarcopenia in geriatric hip fractures: A bibliometric and visualized study

2022

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BackgroundSarcopenia in geriatric hip fractures is attracting increased attention in recent years. This study aimed to explore the bibliometric characteristics and current status of sarcopenia research in hip fractures of older patients.MethodsPublications related to sarcopenia in geriatric hip fracture published between January 2000 and July 2022 were extracted from the Science Citation Index Expanded, and bibliometric and visualized studies were performed by VOSviewer, Citespace, and R.ResultsThe 1,223 articles used in our study were written by 6,326 authors from 1,879 organizations in 60 countries, published in 388 journals, and cited 37,198 references from 5,422 journals. The United States contributed the most publications (288 publications). The journal with the largest number of papers was Osteoporosis International (62 publications), and the Journals of Gerontology Series A - Biological Sciences and Medical Sciences had been more cited than any other journals in this field (3,302 citations). The University of Melbourne published the biggest number of papers (72 publications) focusing on sarcopenia in geriatric hip fractures while the California Pacific Medical Center Research Institute had the largest citations (4,239 citations). Cawthon PM was the most productive and influential author in the field. keywords were classified into 6 clusters: Cluster 1 (sarcopenia in aging), Cluster 2 (osteoporosis), Cluster 3 (bone density), Cluster 4 (body composition), Cluster 5 (physical performance), and Cluster 6 (risk factor).ConclusionGeriatric hip fracture is one of the most significant health issues in the aging society. In the past 20 years, an increasing number of studies were performed to explore the relationship between sarcopenia and hip fracture in older adults. The United States showed the strongest influence in this field, including publication numbers, citations, institutions, funding agencies, and authorship. Sarcopenia in aging, osteoporosis, bone density, body composition, physical performance, and risk factors may become the future hotspots in this field.

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Sarcopenia as a Risk Factor for Future Hip Fracture: A Meta-Analysis of Prospective Cohort Studies

Cited by 22 publications

References 39 publications

Using Dietary Macronutrient Patterns to Predict Sarcopenic Obesity in Older Adults: A Representative Korean Nationwide Population-Based Study

Using Dietary Macronutrient Patterns to Predict Sarcopenic Obesity in Older Adults: A Representative Korean Nationwide Population-Based Study

Prognostic Value of Isolated Sarcopenia or Malnutrition–Sarcopenia Syndrome for Clinical Outcomes in Hospitalized Patients

Mapping knowledge structure and global status of sarcopenia in geriatric hip fractures: A bibliometric and visualized study

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