Sarcopenia in Ukrainian Older Women

Background Nowadays, it is well-known that sarcopenia increases the risk of falls and fractures, and therefore, requires correction in order to improve the quality and duration of life of elderly people. Most of the early performed studies were conducted among community-dwelling subjects without stratification by ethnicity. This research aimed to study the age-related changes in the sarcopenia risk, falls, and fractures in Ukrainian women in the late reproductive and postmenopausal periods. Materials and Methods In the one-center cohort study we examined 573 females aged from 40 to 89 years old. For the analysis, the subjects were grouped by age decades and presence of high sarcopenia risk (HSR). The sarcopenia risk was measured by Strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, the risk of falls using the Desmond Fall Risk Questionnaire, 10-year probability of major osteoporotic and hip fractures was assessed by Fracture Risk Assessment Tool, and daily activity – according to the Instrumental Activities of Daily Living scale. Also, we measured the hand grip strength and performed a five-repetition sit-to-stand test. Results The frequency of HSR increased with age from 1.5% in the 40-49-year-old group to 73.7% in the subjects over 80 years old, as well as fracture and fall risks (p ˂ 0.00001 for both indices) that were related to decreasing of independence in subjects everyday life. Also, we revealed age-dependent loss of muscle strength according to the hand grip and the five-repetition sit-to-stand test. After the adjustment of the subjects by age we found that the females with HSR had a higher risk of falls, a lower level of independence, and increased frequency and risk of osteoporotic fractures. Conclusion Women with HSR have a higher risk of falls, fractures, and more limitations in daily living activities independently from age and body mass index. These findings request comprehensive management of older women with attention to various parameters for the increase of independence and quality of life.

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“…Studies of the prevalence of sarcopenia in the Ukrainian population had been started in 2010-2012 [13].…”

Section: Discussionmentioning

confidence: 99%

“…All questionnaires were translated and adapted earlier into Ukrainian [13,14]. All subjects had completed the questionnaires themselves after a preliminary instruction by the researcher.…”

Section: Questionnairesmentioning

confidence: 99%

Age-associated risk of sarcopenia, falls and fractures: results of Ukrainian cohort study

Grygorieva

Musiienko

Bystrytska

2023

Preprint

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“…The most important thing is that the lack of definitions causes difficulties in establishing an accurate diagnosis, conducting epidemiological studies and developing strategies for the prevention and treatment of this disease. For today, studies have been conducted in Ukraine on determining the cut-off values for sarcopenia [18], but no studies have been conducted on the criteria and assessment of the epidemiology of sarcopenic obesity. Thus, the aim of our study was to determine the fat-percentage cut-off values for the diagnosis of sarcopenic obesity in the Ukrainian population.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenic obesity: epidemiology and cut-off values in the Ukrainian population

Grygorieva,

Bystrytska,

Musiienko

2023

Fiziol Zh

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Sarcopenic obesity is a term increasingly used to describe the loss of muscle mass (sarcopenia) and obesity associated with aging and chronic disease. There is still no commonly accepted definition of sarcopenic obesity and its diagnostic criteria, which affects the determination of its prevalence, assessment of clinical significance, and negative health consequences. The aim of the study was to assess the fat and lean mass cut-off values for sarcopenic obesity in the Ukrainian population. We used the Zoico method (60th percentile) in a cohort of 3095 subjects (2666 women and 429 men) aged 20-90 years old for assessment of the fat-percentage cut-off values. Cut-off values for lean mass were calculated as –2 SD in 770 healthy subjects (385 females and 385 males) aged 20-39 years old. The fat and lean mass parameters were assessed using dual-energy X-ray absorptiometry (DXA, Hologic, Discovery). The use of different diagnostic criteria for sarcopenic obesity demonstrated its wide variability in men (0-6.5%) and women (0.1-10.5%), which justifies the need to determine Ukrainian population cut-off values. Zoico cut-off values for fat mass were >41% for females and >28% for males. The cut-off values for the ratio of appendicular lean mass to body weight were <22% for women and <28% for men. Our study revealed that the frequency of sarcopenic obesity in the Ukrainian population aged 20-90 years old, using our cut-off values consisted of 9.8% for women and 9.6% for men.

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“…Diseases of musculoskeletal system and; in particular, osteoporosis is one of the most important contemporary problems. Osteoporosis affects about onethird to half of all women in the postmenopausal period [1][2][3]. In majority of cases, primary clinical signs of osteoporosis are low-energetic and minimally traumatic fractures remaining straight complications of this disease.…”

Section: Introductionmentioning

confidence: 99%

Effects of Complex Treatment by Use of Fetal Stem Cells on Bone Mineral Density in Postmenopausal Women

2021

JES

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Analysis of bone mineral density index and a 10-year risk of fractures have been performed and two groups of postmenopausal women under the study were compared. Both investigated groups were randomized and conventional therapy by use of medicines including peroral administration of vitamin D3 and bisphosphonate were prescribed due to special indication. In treatment of the main group (MG), women along with standard therapy methods had been receiving treatment by use of fetal stem cells (FSCs). In accordance with the results and comparison between the groups, bone mineral density of femoral neck and trochanter became significantly higher in the group of women who underwent combined treatment with FSCs if compared to the control group (CG). Furthermore, in the MG we noted a tendency to downgrading a 10-year risk of fractures development in postmenopausal women, if compared to the CG upon randomization, where the patients received only a traditional treatment using medicines. This research aims to investigate effectiveness of complex therapy with FSCs derived from 7 to 12-week gestation fetuses and comparing such a treatment influence on certain markers of ageing process in postmenopausal women between the MG and the CG of patients. Criteria for comparing suggested a study of bone mineral density (BMD), as well as 10-year risk of fractures by Fracture Risk Assessment Tool (FRAX), which are the markers of agerelated changes of the skeletal system in women.

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Sarcopenia in Ukrainian Older Women

Cited by 3 publications

References 0 publications

Age-associated risk of sarcopenia, falls and fractures: results of Ukrainian cohort study

Age-associated risk of sarcopenia, falls and fractures: results of Ukrainian cohort study

Sarcopenic obesity: epidemiology and cut-off values in the Ukrainian population

Effects of Complex Treatment by Use of Fetal Stem Cells on Bone Mineral Density in Postmenopausal Women

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