Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults

Prior, Steven J.; Ryan, Alice S.; Blumenthal, Jacob B.; Watson, J.; Katzel, Leslie I.; Goldberg, Andrew P.

doi:10.1093/gerona/glw017

Cited by 86 publications

(77 citation statements)

References 41 publications

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“…Since sarcopenia is associated with lower skeletal muscle capillarization [42], the effect of baicalein on muscle capillarization was interesting; however, the effect of baicalein on muscle capillarization has not been described yet. We analysed the number of capillaries per 0.5 mm 2 muscle tissue in M. soleus (3A), M. gastrocnemius (Figure 3(b)), and M. longissimus (Figure 3(c)).…”

Section: Resultsmentioning

confidence: 99%

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Saul

Kling

Kosinsky

et al. 2016

Journal of Nutrition and Metabolism

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Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle. In this study, sixty-one female Sprague Dawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX). Eight weeks after ovariectomy, three disparate concentrations (1 mg/kg body weight (BW), 10 mg/kg BW, and 100 mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups. Mm. soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, and muscle weights as well as number of capillaries per fibre were recorded. In Mm. soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied. The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups. In M. longissimus, we observed a shift to type IIa fibres. Serum creatine kinase levels were significantly lower in highest baicalein concentration group. We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats. Therefore, a protective effect of baicalein on muscle cells can be assumed.

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Section: Resultsmentioning

confidence: 99%

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Saul

Kling

Kosinsky

et al. 2016

Journal of Nutrition and Metabolism

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“…156 Besides the muscular force, muscular endurance is negatively associated with BMI, 157 which is also a characteristic of sarcopenia. 158 Interestingly, subcutaneous fat does not appear to induce muscle wasting to the same extent as visceral fat. Consistently, the increase in visceral and not total fat mass upregulated ubiquitin ligase, muscle RING-finger protein-1 (MuRF-1), caspase-3, and poly-ADP-ribose polymerase cleavage in muscle of rats with obesity.…”

Section: Sarcopeniamentioning

confidence: 96%

“…Similar to ageing, obesity triggers the infiltration of fat into muscle, which could be a cause of early development of sarcopenia as the intramuscular lipid droplets hinder the regeneration potential and function of skeletal muscle . Besides the muscular force, muscular endurance is negatively associated with BMI, which is also a characteristic of sarcopenia . Taken together, patients with obesity have been shown to have difficulty in performing activities of daily living and are more at risk of falls and fractures, common features of sarcopenia and ageing.…”

Section: Obesity and Age‐related Diseasesmentioning

confidence: 99%

Obesity and ageing: Two sides of the same coin

2020

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Summary Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are “two sides of the same coin” through discussing how obesity predisposes an individual to age‐related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early‐onset of chronic diseases in obesity parallel those of ageing.

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“…Our observations suggest that skeletal muscle capillarisation may play a role in the maintenance of muscle mass and a reduction in angiogenesis may contribute to sarcopenia and physical decline in elderly people [18]. Indeed, animal studies have shown that endothelial cell apoptosis and impairment in capillary function leads to a decline in muscle mass [30].…”

Section: Discussionmentioning

confidence: 99%

“…Their release is stimulated by bone-derived cytokines as well as hypoxia, simulating bone injury. It has also been proposed that sarcopenia or muscle weakness due to ageing may be related to reduced capillary density in the muscles [18]. Levels of various angiogenic factors may decline in muscles with ageing.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Body Composition are Associated with Circulating Angiogenic Factors in Post-menopausal Women

et al. 2016

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Lean mass (LM) and fat mass (FM) are closely related to bone mass (BM) in post-menopausal women, although their relative importance is unclear. Angiogenic factors which control angiogenesis may influence BM, LM and FM. The aim of the study was to compare the contribution of LM and FM to bone mineral density (BMD) and the association between these tissues and circulating angiogenic factors. The study population comprised of 392 post-menopausal women aged mean [SD] 61.8 [6.4] years. BMD was measured at the lumbar spine (LS), neck of femur and total hip (TH) by dual-energy X-ray absorptiometry (DXA). DXA scan was also used to determine LM and FM. Angiopoietin-1 and 2 (ANG-1, ANG-2) were measured by sandwich enzyme-linked immunosorbent assay. Following adjustment for confounders, significant positive independent associations were seen between LM with BMD at all skeletal sites (TH: p < 0.0001) and FM with BMD at the hip sites (TH: p = 0.004). When BMD and LM were regressed against the angiogenic factors, positive associations were seen between ANG-2 with LM (p = 0.002) and LS BMD (p = 0.05). Negative associations were observed between the ratio of ANG-1/ANG-2 with LS BMD (p = 0.014), TH BMD (p = 0.049) and LM (p = 0.029). FM and fat distribution (android/gynoid fat ratio) were negatively associated with ANG-1 (p = 0.006) and ANG-2 (p = 0.004), respectively. ANG-1 and ANG-2 may be involved in the maintenance of bone, muscle and fat mass.

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Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults

Cited by 86 publications

References 41 publications

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

Obesity and ageing: Two sides of the same coin

Bone Mineral Density and Body Composition are Associated with Circulating Angiogenic Factors in Post-menopausal Women

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