Sarcopenic obesity predicts nonremission of late‐life depression

Kokkeler, Kitty J.E.; Berg, Karen van den; Comijs, Hannie C.; Voshaar, Richard C. Oude; Marijnissen, Radboud M.

doi:10.1002/gps.5121

Cited by 19 publications

(21 citation statements)

References 61 publications

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“…A previous study found that abdominal obesity (waist circumference) exerts a modification effect on both handgrip strength and depression, reminding us that obesity combined with low handgrip strength exerts a cumulative effect on the risk of depression. 34 In addition, other studies have reported that depression combined with obesity among older adults can lead to lower handgrip strength. 35 Our study did not find any differences in any BMI stratum.…”

Section: Discussionmentioning

confidence: 99%

Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study

Zhang¹,

Jiao²,

Cao³

et al. 2021

NDT

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Objective There have been studies exploring the association between handgrip and depression among community-dwelling adults; however, evidence for this association among hospitalized older adults is scarce. We aimed to use a larger-scale population from multiple centers to explore the association between low handgrip strength and depression. Methods This was a cross-sectional study that included hospitalized patients aged 65 years or older from different hospitals in China. Depression was assessed by a short-form Chinese Geriatric Depression Scale (GDS-15) with a cutoff value of 5 points or more. Dominant hand handgrip strength was assessed by a dynamometer. A generalized additive model and multivariable regression analysis were conducted. Results There were 9,368 participants, with an average age of 72.4 (SD=5.7) in the final analysis. The prevalence of low handgrip strength and depressive symptoms among older Chinese hospitalized patients was 50.3% and 16.3%, respectively. There seemed to be a nonlinear relationship between handgrip strength and depression, and curve fitting and threshold analyses indicated that when handgrip strength was less than 35.6 kg, the depression risk decreased significantly with increasing handgrip strength. However, this association between handgrip strength and depression was not significant when the handgrip strength was greater than 35.6 kg. In addition, after adjusting for potential confounders, older patients with low handgrip strength had an increased risk of depression compared to those with normal handgrip strength (OR=1.46; 95% CI=1.27–1.68). The subgroup analysis found the results were unchanged. Conclusion Our study indicates that low handgrip strength was associated with a higher risk of depression among older Chinese hospitalized patients, implying that early patient screening for handgrip strength and initiating effective intervention programs, such as resistance training and nutritional supplements, could be helpful for older patients.

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Section: Discussionmentioning

confidence: 99%

Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study

Zhang¹,

Jiao²,

Cao³

et al. 2021

NDT

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“…Recently, the presence of sarcopenia and low muscle strength was proposed as one possible mechanism explaining the increased fall risk associated with frailty (Hayashi et al, 2019;Kokkeler, Berg, Comijs, Oude Voshaar, & Marijnissen, 2019;Szlejf, Suemoto, & Brunoni, 2018). The interaction between SSRI usage and frailty might be explained by the biological effects of the antidepressants on the central nervous system, such as sedation (Ray, 1992), the cardiovascular system, causing postural hypotension (Halper & Mann, 1988) and anticholinergic activity (Fick, Semla, Beizer, & American Geriatrics Society, 2015), affecting the capability to maintain the integrity of one's gait and motor function and increasing the risk of falls.…”

Section: Discussionmentioning

confidence: 99%

Serotonin receptor inhibitor is associated with falls independent of frailty in older adults

Lin

Borges

Siqueira

et al. 2019

Aging & Mental Health

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Objectives: To evaluate whether fall risk in older adults is associated with the use of selective serotonin receptor inhibitor (SSRI) monotherapy among geriatric outpatients, and whether this association is moderated by the presence of depressive disorder and/or frailty. Methods: Prospective cohort study with a 12-month follow-up and including 811 communitydwelling adults aged 60 or older from a university-based Geriatric Outpatient Unit. Major depressive disorder (MDD) was diagnosed according to DSM-5 criteria; subsyndromal depression as not meeting MDD criteria, but a Geriatric Depression Scale 15-item score ! 6 points. Frailty was evaluated with the FRAIL questionnaire. The association between SSRI use, depression, or both as well as the association between SSRI use, frailty, or both with falls were estimated through a generalized estimating equation (GEE) adjusted for relevant confounders. Results: At baseline, 297 patients (36.6%) used a SSRI (82 without remitted depression) and 306 (37.7%) were classified as physically frail. Frailty was more prevalent among SSRI users (44.8% versus 33.7%, p ¼.004). After 12 months, 179 participants had at least one fall (22.1%). SSRI use, depression as well as frailty were all independently associated with falls during follow-up. Nonetheless, patients with concurrent of SSRI usage and non-remitted depression had no higher risk compared to either remitted SSRI users or depressed patients without SSRIs. In contrast, concurrence of SSRI use and frailty increases the risk of falling substantially above those by SSRI usage or frailty alone. Conclusion: SSRI usage was independently associated with falls. Especially in frail-depressed patients, treatment strategies for depression other than SSRIs should be considered.

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“…Although the underlying mechanisms connecting depression to accelerated ageing are not well understood, depression has been associated with ageing at the molecular level, for example, DNA damage and mitochondrial dysfunction, the cellular level, for example, telomere attrition, protein accumulation and abnormal secretory patterns, and lastly, at the tissue and system level, for example, sarcopenia and metabolic diseases. [32][33][34][35][36] Our study also connects depression to a clinical level of senescence, namely frailty. From a clinical perspective, depressed older patients should be considered at increased risk of becoming frail and thus constitute a sample suitable for selective prevention of frailty.…”

Section: Reciprocal Associations Between Depression and Frailtymentioning

confidence: 95%

A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

Voshaar

Dimitriadis

vandenBrink

et al. 2021

Int J Geriat Psychiatry

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Introduction: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. Methods:A cohort study with 6-year follow-up including 377 older (≥60 years) outpatients with a DSM-IV-defined depressive disorder and 132 never-depressed controls. Site visits at baseline, 2 and 6-year follow-up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates.Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41-item FI was operationalised and validated against the 6-year morality rate by Cox regression (HR FI = 1.04 [95% CI: 1.02-1.06]).Results: Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR FI = 0.98 [95% CI: 0.97-0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. Conclusions:The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM-IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of latelife depression.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Sarcopenic obesity predicts nonremission of late‐life depression

Cited by 19 publications

References 61 publications

Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study

Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study

Serotonin receptor inhibitor is associated with falls independent of frailty in older adults

A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

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