Sari Etanol, Etil Asetat Alang-Alang (Imperata Cylindrica) Terhadap Superoxide Dismutase (Sod)

Abstract

Oxidative stress has been considered as a mechanism involved in the pathogenesis and progression of many diseases such as:hypercholesterolemia and atherosclerosis. The objective of this current study was to know the potential antioxidant role of ethanol andethyl acetate extract of reeds (Imperata cylindrica) by investigation in rats fed with a high-cholesterol diet. Imperata cylindrica is richin antioxidants and has a cholesterol-reducing effect. A group of twenty four male albino Wistar rats was divided into four subgroups: anormal diet group (K0), a high-cholesterol diet group (K1), the same diet with ethanol extract of Imperata cylindrica group (K2), and thesimilar diet with ethyl acetate fraction of Imperata cylindrica group (K3),. After the treatment period, the hepatic antioxidant enzymeactivity (Superoxide dismutase/SOD) was determined. The rats fed on high-cholesterol diet with supplementation exhibited a significantelevation in SOD activity (p<0. 05), 61.6±12.4% inhibition, compared to normal animals 37.44±12.2%. The treated animals withethanol and ethyl acetate extract of Imperata cylindrica showed a significantly reduced the level of SOD activity (p<0.05, 29.90±5.6%as well as a 33.49±7.4% inhibition). The level of SOD activity when restored was closer to that in normal animals, signifying reversalof the oxidative stress. The study results showed that the treatment with Imperata cylindrica positively changed the hepatic antioxidantenzyme activities in high fat-diet rats, and thus had potential hypocholesterolemic and antioxidant effects. Imperata cylindrica couldprotect against oxidative stress linked to atherosclerosis and also decrease the atherogenic index.

Effect of 7-Hydroxy-2-(4- Hydroxy -3-Methoxyphenyl)-Chroman-4-one On Level of Mangan-Superoxide Dismutase (Mn-Sod) and Superoxide Dismutase 2 (Sod2) Gene Expression in Hyperlipidemia Rats

“…The absence of Nrf2 from Keap1 causes Nrf2 transmigrated from the cytoplasm to the nucleus. Nrf2 in the nucleus will bind to the antioxidant element response (ARE) thus increasing the expression of the SOD2 gene (Khaerunnisa et al, 2014;Vomhof-DeKrey and Picklo, 2012).…”

Studies on the Benefits of Cogon Grass (Imperata cylindrica L) in Indonesia: A Review

“…The results of pharmaceutical studies of cogon grass show that cogon grass extract has the following properties: Anticancer [27] , antilithiasis [28][29] , antioxidant [30][31][32][33] , antipyretic [35][36] , analgesic [37] , anti-inflammatory [38][39] , antilarvae [41][42] . In other studies, related to health, cogon gras extract is known to reduce male fertility [44,46] , increase antibodies [47] , increase male stamina [49] , and increase body weight [50] .…”