2020
DOI: 10.21203/rs.3.rs-32464/v1
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SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury

Abstract: Background Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif containing 1), the fifth TLR (Toll-like receptor) adaptor, has diverse functions in the immune and nervous systems, and recently has been identified as a key mediator of Wallerian degeneration (WD). However, the detailed functions of SARM1 after SCI still remain unclear. Methods Modified Allen’s method was used to establish a cont… Show more

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