SARS-CoV-2 and HIV co-infection; clinical features, diagnosis, and treatment strategies: A systematic review and meta-analysis

Dadashi, Masoud; Dadashi, Ali; Sameni, Fatemeh; Sayadi, Shahram; Goudarzi, Mehdi; Nasiri, Mohammad Javad; Yaslianifard, Somayeh; Ghazi, Mona; Arjmand, Reza; Hajikhani, Bahareh

doi:10.1016/j.genrep.2022.101624

Cited by 5 publications

(4 citation statements)

References 100 publications

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“…Shrestha et al (2023) Com relação aos aspectos biológicos, pacientes com coinfecção de HIV e covid-19 apresentam uma menor resposta imune humoral contra a covid-19 e, consequentemente, redução da produção de anticorpos contra o SARS-CoV-2, em comparação aos pacientes sem HIV (Liu et al, 2021). Com isso, é esperado que a coinfecção de HIV e covid-19 aumente o risco de morte, com a taxa de mortalidade podendo alcançar 17% (Dadashi et al, 2022).…”

Section: Resultsunclassified

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

De Santana,

Pinheiro,

Montarroyos

2024

CLCS

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A doença covid-19 tem amplo espectro de apresentação clínica, que vai desde indivíduos que não manifestam sintomas aos pacientes com doença respiratória grave que podem progredir para o óbito. Pessoas que vivem com HIV são particularmente mais vulneráveis a contrair o SARS-CoV-2 e a desenvolver formas graves da doença, tendo, inclusive, maior risco de hospitalização e morte. Ainda há muito a ser investigado sobre o HIV e a covid-19, então o objetivo deste estudo foi explorar os principais aspectos clínicos e biológicos da coinfecção. Assim sendo, este estudo se trata de uma revisão sistemática sobre a coinfecção de HIV e covid-19 elaborada a partir de um levantamento de artigos publicados de março de 2020 a dezembro de 2023 nas bases de dados SCIELO, BVS e Pubmed. Os descritores utilizados foram covid-19, vírus SARS-CoV-2, HIV, coinfecção, sintomas e biologia, sendo feita a combinação entre estes descritores através do operador booleano ‘’and’’. Após aplicação dos critérios de inclusão e exclusão, 28 artigos foram selecionados para a construção da revisão sistemática. Em relação aos achados clínicos da coinfecção de covid-19 e HIV, observou-se que os sintomas mais comumente encontrados foram semelhantes aos de pacientes com covid-19 e sem HIV e, dentre eles, os mais frequentes foram febre, tosse, dispneia e mialgia. No que diz respeito aos aspectos biológicos da coinfecção de HIV e covid-19, ambas as doenças provocam desregulação do sistema imune do hospedeiro, o que justifica a alta morbimortalidade decorrente da coinfecção.

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Section: Resultsunclassified

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

De Santana,

Pinheiro,

Montarroyos

2024

CLCS

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“…• Intervention to change people's behavioral patterns with the help of social mobilizations (15). • Dealing with health inequalities (18). • Choosing the right behaviors and decisions (18).…”

Section: Lessons From Hiv In Response To Monkeypox Using Political Le...mentioning

confidence: 99%

“…• Dealing with health inequalities (18). • Choosing the right behaviors and decisions (18). • Using similar researches and epidemiological models (19).…”

Section: Lessons From Hiv In Response To Monkeypox Using Political Le...mentioning

confidence: 99%

Human monkeypox companionship and sexually transmitted diseases; lessons from the HIV pandemic for monkeypox response

et al. 2022

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There are many unknowns and much uncertainty in connection with the recent monkeypox (MPX) outbreak. But is the world ready for a new common viral disease? The aim of this study was to investigate the effects of MPX companionship and STI diseases and in lessons where the HIV pandemic can be used to control MPX outbreaks. A critical literature review, based on the findings from 12 primary research articles. Explores the effects of MPX outbreak on HIV and the lessons that can be used from HIV to control MPX outbreaks. MPX outbreak affects different aspects of patients’ lives. With HIV and by learning from past epidemics of this disease, it is possible to reduce the number of injuries to patients and improve the services received and the quality of life of these patients.

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“…Fever, coughing, and shortness of breath are the most prevalent symptoms ( 7 , 8 ). Asymptomatic carriers and severe clinical symptoms, which include septicemia and severe respiratory distress, are among the manifestations of COVID-19 ( 9 ). Severe symptoms requiring intensive care were experienced by about 5% of patients with COVID-19 and 20% of inpatients ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy

et al. 2022

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Recent evidence proposed that the severity of the coronavirus disease 2019 (COVID-19) in patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18, TNF-α, and IFN-γ. Hence, managing the cytokine storm by drugs has been suggested for the treatment of patients with severe COVID-19. Several of the proinflammatory cytokines involved in the pathogenesis of COVID-19 infection recruit a distinct intracellular signaling pathway mediated by JAKs. Consequently, JAK inhibitors, including baricitinib, pacritinib, ruxolitinib, and tofacitinib, may represent an effective therapeutic strategy for controlling the JAK to treat COVID-19. This study indicates the mechanism of cytokine storm and JAK/STAT pathway in COVID-19 as well as the medications used for JAK/STAT inhibitors.

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SARS-CoV-2 and HIV co-infection; clinical features, diagnosis, and treatment strategies: A systematic review and meta-analysis

Cited by 5 publications

References 100 publications

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

Perfil clínico e biológico da coinfecção de HIV e COVID-19: uma revisão sistemática

Human monkeypox companionship and sexually transmitted diseases; lessons from the HIV pandemic for monkeypox response

COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy

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