SARS-CoV-2 detection in patients with influenza-like illness

Kong, Wen; Li, Yao; Peng, Ming; Kong, De Guang; Yang, Xiao Bing; Wang, Leyi; Liu, Man‐Qing

doi:10.1038/s41564-020-0713-1

Cited by 170 publications

(160 citation statements)

References 15 publications

Supporting

Mentioning

155

Contrasting

Order By: Relevance

“…On mapping, 101 hub proteins were shared between the lung diseases suggesting a common mechanism relating disease symptoms and/or vulnerability (S3 Table). Also mapping with other viral infection dataset, 50 hub proteins of the replication machinery network have noticed in influenza virus infection (S4 Table), which suggests SARS-CoV2 and influenza may have a similar mode of host infection machinery [17].…”

Section: Discussionmentioning

confidence: 88%

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

Shiek

Prabu

Raj

et al. 2020

Preprint

View full text Add to dashboard Cite

We dissect the mechanism of SARS-CoV-2 in human lung host from the initial phase of receptor binding to viral replication machinery. We constructed two independent lung protein interactome to reveal the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis of virus. Further, we test the functional role of the hubs derived from both interactome. Most hubs proteins were differentially regulated on SARS-CoV-2 infection. Also, the proteins of viral replication hubs were related with cardiovascular disease, diabetes and hypertension confirming the vulnerability and severity of infection in the risk individual. Additionally, the hub proteins were closely linked with other viral infection, including MERS and HCoVs which suggest similar infection pattern in SARS-CoV-2. We identified five interconnecting cascades between hubs of both networks that show the preparation of optimal environment in the host for viral replication process upon receptor attachment.Interestingly, we propose that seven potential miRNAs, targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2.

show abstract

Section: Discussionmentioning

confidence: 88%

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

Shiek

Prabu

Raj

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The number of in uenza-like illness (ILI) cases in all age groups increased dramatically starting in early December 2019 and reached the peak by the New Year of 2020. In addition, ILI data for the 2019-2020 winter season was signi cantly higher in comparison to previous years, suggesting the necessity to distinguish between in uenza-infected and suspected COVID-19 patients 1 .…”

Section: Introductionmentioning

confidence: 89%

Influence of influenza A virus in COVID-19 patients: A retrospective cohort study

Cheng

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background and objective: Coronavirus disease (COVID-19) is currently an urgent global issue, but we cannot ignore the impact of influenza A since there is an overlap of infection time and region and similar clinical manifestations and chest computed tomography (CT) images for influenza A and COVID-19 infections. We compared patients who had a COVID-19 infection and co-infection with the influenza A virus.Methods: We retrospectively reviewed patients who met the inclusion criteria for this study.Results: There were 213 patients included in this study, of whom 106 were females and 107 were males, with a median age of 63 years. All patients were diagnosed with COVID-19 and were subsequently divided into influenza positive (n = 97) and influenza negative (n = 116) groups according to the serum test results for the influenza A IgM antibody. The two groups had similar symptoms, outcomes, CT manifestation and CT scores, except for lymphadenopathy (6.2% in the influenza positive group vs. 14.7% in the negative group, P = 0.047). However, in the subgroup analysis, male or younger patients (age <= 60 years) in the influenza negative group had higher CT scores than patients in the influenza positive group (P < 0.05).Conclusions: COVID-19 patients who had co-infection with the influenza A virus showed similar symptoms, outcomes, CT manifestation and CT scores to influenza negative patients. However, male patients and younger patients had higher CT scores in the influenza negative group.

show abstract

“…from December 30, 2019 to January 19, 2020 . A retrospective study identified nine ILI adult cases of COVID-19 from two hospitals in central Wuhan (2) . We estimate that there were a total of 5,558 [95% CI: 2,761-9,864] cases of COVID-19 in adults during that 21-day period across the 13 central districts of Wuhan, ranging from 75 cases [95% CI: 37-133] in suburban Hannan to 711 cases [95% CI: 353-1,262] in central Wuchang, as indicated by shading (Table S1).…”

Section: Figure Estimated Symptomatic Covid-19 Infections In Adults mentioning

confidence: 99%

“…In addition to the nine COVID-19 positive samples, seven others tested positive for influenza (2) . Coupling the ratio between COVID-19 and influenza positive tests with an estimate for influenza prevalence in Wuhan during the same time derived from surveillance data (see Appendix), we estimate that there were 5,558 [95% CI: 2,761-9,864] adults with symptomatic COVID-19 infections in Wuhan between December 30th and January 19th, ranging from 75 cases [95% CI: 37-133] in suburban Hannan to 711 cases [95% CI: 353-1,262] in central Wuchang (Figure).…”

mentioning

confidence: 99%

Using the COVID-19 to influenza ratio to estimate the numbers of symptomatic COVID-19 cases in Wuhan prior to the lockdown

Cowling

Meyers

2020

Preprint

View full text Add to dashboard Cite

show abstract

SARS-CoV-2 detection in patients with influenza-like illness

Cited by 170 publications

References 15 publications

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

Interplay of host regulatory network on SARS-CoV-2 binding and replication machinery

Influence of influenza A virus in COVID-19 patients: A retrospective cohort study

Using the COVID-19 to influenza ratio to estimate the numbers of symptomatic COVID-19 cases in Wuhan prior to the lockdown

Contact Info

Product

Resources

About