SARS-CoV-2 induced necrotizing pancreatitis

Maalouf, Rami George; Kozhaya, Karim; Zakhem, Aline El

doi:10.1016/j.medcli.2021.01.005

Cited by 5 publications

(1 citation statement)

References 5 publications

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“… 3 In published literature, numerous cases of COVID-19 complicated with AP have been reported ( Table 1 ). 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 However, no robust causative relationship has been established between them.…”

Section: Introductionmentioning

confidence: 99%

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Tang

Gao

Tong

et al. 2022

The American Journal of the Medical Sciences

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Section: Introductionmentioning

confidence: 99%

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Tang

Gao

Tong

et al. 2022

The American Journal of the Medical Sciences

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Fatal gastrointestinal bleeding associated with acute pancreatitis as a complication of Covid-19: a case report

Mitrović¹,

Tadić

Janković³

et al. 2022

J Int Med Res

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Clinical manifestations of Covid-19 vary widely among patients. Recent studies suggest that up to 15% of patients with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections develop gastrointestinal symptoms. The location of virus–host cell receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 has an important role in the pathophysiology and presentation of disease. They are expressed in the respiratory tract, as well as other organs and tissues including exocrine and endocrine pancreatic cells. These cells are therefore a possible target for the virus, which could explain the relationship between SARS-CoV-2 infection and pancreatic injury. We report a disastrous collateral effect of the Covid-19 pandemic on a 33-year-old man with chronic renal insufficiency and asymptomatic SARS-CoV-2 infection, who developed acute pancreatitis. Inflammation progressed rapidly toward necrosis and the development of a peripancreatic pseudoaneurysm which subsequently ruptured, causing death.

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COVID-19 and pancreatitis: A review of the potential association

Kerawala¹,

Das²,

Fatima

et al. 2023

Int J Gastrointest Interv

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Originally thought to be a respiratory pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been shown to cause a dizzying array of symptoms, including all major organ systems of the human body. As time elapsed, new strains of the virus have emerged, validating concerns about genetic mutation. No single treatment has proven beneficial in treating the consequences, and the world has been left at the mercy of this deadly pathogen. It has been proven that COVID-19 can cause strokes, myocardial infarcts, mesenteric infarcts, acute limb ischemia, and a wide array of other symptomatology. This review aimed to evaluate whether there exists an association between COVID-19 and pancreatitis. Forty publications (34 case reports and 4 case series) were included in the review. In total, 44 cases of acute pancreatitis (38 cases of acute edematous pancreatitis and 6 cases of necrotizing pancreatitis) in COVID-19 patients without any predisposing factors have been published since January 2020. Fortunately, only 4 (9.1%) of these patients were reported to have died. Although the exact mechanism by which COVID-19 causes pancreatitis is still unclear, studies so far have reported it as a multifactorial phenomenon. COVID-19 associated pancreatic injury is thought to involve direct cellular damage via local replication of SARS-CoV-2 within pancreatic cells, as they express angiotensin-converting enzyme 2 receptors even more strongly than lung cells. Our review concludes that acute pancreatitis should be kept in the differential list of all COVID-19 patients with gastrointestinal manifestations, especially in patients with acute abdomen.

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SARS-CoV-2 induced necrotizing pancreatitis

Cited by 5 publications

References 5 publications

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Fatal gastrointestinal bleeding associated with acute pancreatitis as a complication of Covid-19: a case report

COVID-19 and pancreatitis: A review of the potential association

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