2023
DOI: 10.3390/biology12020174
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SARS-CoV-2 Infection: A Clinical and Histopathological Study in Pregnancy

Abstract: During pregnancy, SARS-CoV-2 infection is associated with several adverse outcomes, including an increased risk of pre-eclampsia, preterm delivery, hypertensive disorders, gestational diabetes, and fetal growth restriction related to the development of placenta vascular abnormalities. We analyzed human placenta from full-term, uncomplicated pregnancies with SARS-CoV-2 infection during the first, second, or third trimesters of gestation. We studied, by the immunohistochemistry technique, the expression of CD34 … Show more

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Cited by 4 publications
(3 citation statements)
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“…Results showed PDPN expression around the villous stroma as a plexiform network around the villous nuclei of fetal vessels; significant down-regulation was also observed in the villous stroma of women infected during the third trimester. CD34 showed no changes in expression levels [52].…”
Section: Route Of Sars-cov-2 During Pregnancy and Its Consequencesmentioning
confidence: 92%
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“…Results showed PDPN expression around the villous stroma as a plexiform network around the villous nuclei of fetal vessels; significant down-regulation was also observed in the villous stroma of women infected during the third trimester. CD34 showed no changes in expression levels [52].…”
Section: Route Of Sars-cov-2 During Pregnancy and Its Consequencesmentioning
confidence: 92%
“…Using immunohistochemistry, Perna et al [52] studied the expression of CD34 and podoplanin (PDPN) as markers of vasculogenesis in uncomplicated pregnancies with SARS-CoV-2 infection during the first, second, or third trimester of gestation. Results showed PDPN expression around the villous stroma as a plexiform network around the villous nuclei of fetal vessels; significant down-regulation was also observed in the villous stroma of women infected during the third trimester.…”
Section: Route Of Sars-cov-2 During Pregnancy and Its Consequencesmentioning
confidence: 99%
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