SARS-CoV-2 infection and glucose homeostasis in pregnancy. What about antenatal corticosteroids?

Kakoulidis, Ioannis; Ilias, Ιoannis; Koukkou, Eftychia

doi:10.1016/j.dsx.2020.04.045

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…Betamehasone is a steroid from the group of corticosteroids, it was used in pregnancies complicated by SARS-CoV-2 for its immunosuppressive and anti-in ammatory properties. However, a potential diabetogenic effect was found, in addition to that SARS-CoV-2 and other coronavirus may have effects on glycemia [10].…”

Section: Discussionmentioning

confidence: 99%

Repositioning of ligands that target spike glycoprotein as potential drugs against SARS-CoV-2

Ramírez-Salinas¹,

Martínez‐Archundia²,

Correa-Basurto³

et al. 2020

Preprint

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The worldwide health emergency of the SARS-CoV-2 pandemic and the absence of a specific treatment for this new coronavirus have led to the use of computational strategies (drug repositioning) to search for treatments. The aim of this work is to identify FDA-approved drugs with the potential for binding to the spike structural glycoprotein at the hinge site, receptor binding motif (RBM), and fusion peptide (FP) using molecular docking simulations. It was identified drugs that binding to amino acids crucial for down to up conformational change, receptor recognition, and fusion of the viral membrane with the cell membrane. Results show some drugs that bind to hinge site amino acids (Varenicline, or even steroids as Betamethasone) while other drugs bind to crucial amino acids for RBM (Naldemedine, Atovaquone, Cefotetan) or FP (Edarbi, Maraviroc, Difluprednate); and highlights the Saquinavir that binds both the RBM and the FP. Therefore, these drugs could inhibit spike glycoprotein and prevent viral entry (possible anti-COVID-19 drugs). Several drugs are in clinical studies; focused on another pharmacological target (candesartan, Atovaquone, Losartan, Maviroc and Ritonavir) in this work we propose an additional target, the spike glycoprotein. These results can impact in the proposal of treatments that can inhibit the first steps virus replication cycle.

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Section: Discussionmentioning

confidence: 99%

Repositioning of ligands that target spike glycoprotein as potential drugs against SARS-CoV-2

Ramírez-Salinas¹,

Martínez‐Archundia²,

Correa-Basurto³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Corticosteroids relieve the inflammatory response caused by infection via anti-inflammatory and immunoregulatory effects (141). However, studies have shown conflicting results regarding its clinical effects (142)(143)(144).…”

Section: Treatmentmentioning

confidence: 99%

Lessons from SARS‑CoV‑2 and its variants (Review)

et al. 2022

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coVid-19 has swept through mainland china by human-to-human transmission. The rapid spread of SarS-coV-2 and its variants, including the currently prevalent omicron strain, pose a serious threat worldwide. The present review summarizes epidemiological investigation and etiological analysis of genomic, epidemiological, and pathological characteristics of the original strain and its variants, as well as progress in diagnosis and treatment. Prevention and control measures used during the current omicron pandemic are discussed to provide further knowledge of SarS-coV-2. Contents1. introduction 2. epidemiological features 3. clinical and pathological manifestation 4. diagnosis 5. Treatment 6. Measures to protect vulnerable groups: Vaccination 7. conclusion

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“…ACE2 receptors are specific binding sites for the entry of COVID‐19 into the cell, 22 hence caution should be exercised in administration of antenatal corticosteroids to pregnant women prone to preterm labor. 23 …”

Section: Pregnancy and Covid‐19mentioning

confidence: 99%

COVID‐19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis

Meyyazhagan

Pushparaj

Balasubramanian

et al. 2021

Intl J Gynecology & Obste

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Pregnancy changes the body's immune system to counteract the spectrum of infections, including COVID-19, which can pose complications. Pregnant women are less likely to contract COVID-19 infections than the general public. However, pregnant women are at slightly increased risk of becoming severely unwell if they do catch COVID-19, and congenital conditions in pregnant women may worsen the state of infection and lead to critical stages and even mortality. The possibility of vertical transmission has been reported in only a few cases of COVID-19; however, it was not noted in cases of SARS and MERS. Vaccination coverage in pregnant women remains a challenge. Children are the next suspected and vulnerable population to acquire infection after the first and second waves. Children are disproportionately infected compared with older populations, but the severity of infection is less compared to adults. This review highlights the complexities of COVID-19 in pregnant women and the underlying reasons why children tend to be comparatively less severely affected.Ethnicity, nutrition, lifestyle, and therapeutics influence the severity of infection in children. Low expression of angiotensin-converting enzyme 2 receptors, indigenous virus competence, and maternal immunity is the first-line defense for children against COVID-19. Habituating herbal medicines from childhood may help support a robust and defensive immune system to counteract novel antigens and encourage healthy generations.

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SARS-CoV-2 infection and glucose homeostasis in pregnancy. What about antenatal corticosteroids?

Cited by 12 publications

References 18 publications

Repositioning of ligands that target spike glycoprotein as potential drugs against SARS-CoV-2

Repositioning of ligands that target spike glycoprotein as potential drugs against SARS-CoV-2

Lessons from SARS‑CoV‑2 and its variants (Review)

COVID‐19 in pregnant women and children: Insights on clinical manifestations, complexities, and pathogenesis

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