2021
DOI: 10.1007/978-3-030-71697-4_8
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SARS-CoV-2 Infection and the Kidneys: An Evolving Picture

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Cited by 8 publications
(8 citation statements)
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“…No definitive evidence of SARS-CoV-2 in renal biopsy samples was found by in situ hybridization, immunohistochemistry or electron microscopy, leading to hypothesize that direct viral infection of the kidney is an unlikely underlying pathology. These findings suggest that viral infection, influencing innate or adaptive immune responses, could trigger glomerular diseases such as podocytopathies or anti-GBM nephritis, facilitating renal aging and immunosenescence [107]. In the case of COVID-19 this was instead associated with pre-existing autoimmune or alloimmune conditions (LN, MN, allograft rejection), further kidney injury might result from an already developing immunosenescence and inflammaging [108].…”
Section: Evidence For a Role Of Native Immunity In Covid-19 Kidney Injurymentioning
confidence: 99%
“…No definitive evidence of SARS-CoV-2 in renal biopsy samples was found by in situ hybridization, immunohistochemistry or electron microscopy, leading to hypothesize that direct viral infection of the kidney is an unlikely underlying pathology. These findings suggest that viral infection, influencing innate or adaptive immune responses, could trigger glomerular diseases such as podocytopathies or anti-GBM nephritis, facilitating renal aging and immunosenescence [107]. In the case of COVID-19 this was instead associated with pre-existing autoimmune or alloimmune conditions (LN, MN, allograft rejection), further kidney injury might result from an already developing immunosenescence and inflammaging [108].…”
Section: Evidence For a Role Of Native Immunity In Covid-19 Kidney Injurymentioning
confidence: 99%
“…Trauma, cardiovascular surgery, septic shock ( 303 ) and more recently in critical illness due to COVID-19 ( 7 , 295 ), all are associated with generalized EC activation and EC glycocalyx disruption. While proteinuria is common in critically ill patients ( 6 , 8 ), pulmonary and brain EC barrier disruption tend to have greater relevance for outcomes and therapy in these patients.…”
Section: Disruption Of the Ec Macromolecular Barrier In Diseasementioning
confidence: 99%
“…In some cases, endothelial cell (EC) injury predominates, for instance the hemolytic uremic syndrome (HUS) (1), thrombotic thrombocytopenic purpura (TTP) (2), pre-eclampsia (3,4), and nephrotoxicity due to VEGF inhibitors (5). Transient proteinuria also accompanies generalized EC activation, in the presence of sepsis (6) or viral infections (7,8). Microalbuminuria is a feature of widespread EC dysfunction in diabetes (9,10) and in cardiovascular disease, where it is a predictor of cardiovascular risk (11)(12)(13)(14)(15)(16)(17)(18)(19).…”
Section: Introductionmentioning
confidence: 99%
“…Acute and chronic SARS-CoV-2 related kidney injuries are now a well-established potential development of the infection with relevant consequences both in the native and transplant setting [ 6 , 24 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Indeed, more than 40% of COVID-19 hospitalized patients have presented laboratory evidence of kidney injury (i.e., albuminuria, proteinuria, hematuria, increased creatininemia and BUN, and reduced eGFR), eventually leading to acute kidney injury (AKI) and requiring kidney replacement therapy [ 46 , 53 , 54 ].…”
Section: Introductionmentioning
confidence: 99%