SARS-CoV-2 receptor ACE2 and molecular pathway to enter target cells during infection

Najafi, Khadijeh; Maroufi, Parham; Khodadadi, Ehsaneh; Zeinalzadeh, Elham; Ganbarov, Khudaverdi; Asgharzadeh, Mohammad; Kafil, Hossein Samadi

doi:10.1097/mrm.0000000000000237

Cited by 10 publications

(8 citation statements)

References 86 publications

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“…Virus structural proteins play an essential role in maintaining and establishing the morphology and immuno-pathogenesis of the virus [17]. For instance, spike protein plays a role in the coronal appearance of the virus and also enables the virus to attach to angiotensin-converting enzyme 2 (ACE2) receptor-expressing cells in various tissues, including the alveolar epithelial cells (type 2Pneumocytes) of the lung [19]. Spike protein also assists viral entrance by membrane fusion after attachment [20].…”

Section: Characteristics and Pathogenesis Of Sars-cov-2 And Covid-19 ...mentioning

confidence: 99%

Iron Deficiency Anemia and COVID-19

Taghinejad

Asgharzadeh²,

Poor³

et al. 2022

JoMMID

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a significant health and financial issue in the current century. Despite significant attempts to manage the illness, the transmission routes of the virus and its widespread genomic mutations have led to an increasing number of new infections and mortality rates. In the absence of specific treatment for this new virus, identifying and managing factors affecting the prognosis of the disease is one of the critical strategies to reduce disease mortality. Patients with iron deficiency anemia (IDA), who account for an estimated half a billion people globally, are more prone to infections due to immune system disorders. Since they visit hospitals more frequently for followup care and diagnosis, they are more susceptible to becoming infected with SARS-CoV-2. Once infected with SARS-CoV-2, low hemoglobin (Hb) levels and compromised immune systems disrupt the restriction of infection in these individuals, ultimately leading to severe complications of COVID-19.

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Section: Characteristics and Pathogenesis Of Sars-cov-2 And Covid-19 ...mentioning

confidence: 99%

Iron Deficiency Anemia and COVID-19

Taghinejad

Asgharzadeh²,

Poor³

et al. 2022

JoMMID

Self Cite

View full text Add to dashboard Cite

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“…COVID-19, which stands for Coronavirus Disease 2019, is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). So far, COVID-19 has contaminated over 769 million individuals worldwide, with approximately 7 million mortalities ( Najafi et al, 2022 ; World-Health-Organization, 2023 ). The spike (S) protein of the virus has a high affinity to the angiotensin-converting enzyme 2 (ACE2) receptor, which is essential for its endocytosis and quick spread in individuals.…”

Section: Introductionmentioning

confidence: 99%

Central nervous system manifestations following vaccination against COVID-19

Khatami,

Revheim,

Høilund-Carlsen

et al. 2024

Brain, Behavior, & Immunity - Health

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“…Some preventive measures, such as social distancing and lockdown of cities, have been adopted to control the COVID-19 pandemic [ 3 ]. SARS-CoV-2 has become a global public health hazard despite concerted measures to maintain the virus's high transmissibility in specific places [ 4 , 5 ]. At a minimum, an optimal therapy should speed symptomatic recovery, limit viral transmission in the population through early viral clearance from the infected individuals, and reduce mortality [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Products as a Potential Source of Promising Therapeutics for COVID‐19 and Viral Diseases

Bafandeh

Khodadadi

Ganbarov

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. A global pandemic has recently been observed due to the new coronavirus disease, caused by SARS-CoV-2. Since there are currently no antiviral medicines to combat the highly contagious and lethal COVID-19 infection, identifying natural sources that can either be viricidal or boost the immune system and aid in the fight against the disease can be an essential therapeutic support. Methods. This review was conducted based on published papers related to the herbal therapy of COVID-19 by search on databases including PubMed and Scopus with herbal, COVID-19, SARS-CoV-2, and therapy keywords. Results. To combat this condition, people may benefit from the therapeutic properties of medicinal plants, such as increasing their immune system or providing an antiviral impact. As a result, SARS-CoV-2 infection death rates can be reduced. Various traditional medicinal plants and their bioactive components, such as COVID-19, are summarized in this article to assist in gathering and debating techniques for combating microbial diseases in general and boosting our immune system in particular. Conclusion. The immune system benefits from natural products and many of these play a role in activating antibody creation, maturation of immune cells, and stimulation of innate and adaptive immune responses. The lack of particular antivirals for SARS-CoV-2 means that apitherapy might be a viable option for reducing the hazards associated with COVID-19 in the absence of specific antivirals.

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SARS-CoV-2 receptor ACE2 and molecular pathway to enter target cells during infection

Cited by 10 publications

References 86 publications

Iron Deficiency Anemia and COVID-19

Iron Deficiency Anemia and COVID-19

Central nervous system manifestations following vaccination against COVID-19

Natural Products as a Potential Source of Promising Therapeutics for COVID‐19 and Viral Diseases

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