SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy

Sandri, Maria Teresa; Azzolini, Elena; Torri, Valter; Carloni, Sara; Pozzi, Chiara; Salvatici, Michela; Tedeschi, Michèle; Castoldi, Massimo; Mantovani, Alberto; Rescigno, María

doi:10.1038/s41598-021-91773-4

Cited by 22 publications

(33 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…New evidence was consistent with prior updates in finding no consistent association between risk for SARS-CoV-2 infection in HCWs and age (13 studies [ 6 , 8 , 10 , 11 , 14–17 , 19 , 22–25 ]), sex (13 studies [ 6 , 8 , 10 , 11 , 13 , 14 , 16 , 17 , 19 , 22–25 ]), or HCW role (15 studies [ 6 , 7 , 11–16 , 19–25 ]) ( Supplement Table 2 ). Also consistent with prior updates, 5 studies done in the United States, Canada, or Ireland found that non-White race (Black, Asian or Asian/Pacific Islander, or combined non-White races) or Hispanic ethnicity was associated with increased risk for infection ( Supplement Table 2 ) ( 6 , 8 , 11 , 15 , 16 ).…”

supporting

confidence: 81%

Update Alert 10: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

et al. 2022

View full text Add to dashboard Cite

supporting

confidence: 81%

Update Alert 10: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

et al. 2022

View full text Add to dashboard Cite

“…Moreover, we previously showed (Lombardi et al) that the exposure within the community probably represented an important mode of HCW infection during 1st wave [6]. The same conclusion is offered by other groups [24][25][26].…”

Section: Discussionsupporting

confidence: 67%

Nasopharyngeal Testing among Healthcare Workers (HCWs) of a Large University Hospital in Milan, Italy during Two Epidemic Waves of COVID-19

Comelli

Consonni

Lombardi

et al. 2021

IJERPH

View full text Add to dashboard Cite

Background: since October 2020, a second SARS-CoV-2 epidemic wave has hit Italy. We investigate the frequency of positive nasopharyngeal swabs among HCWs during the two waves and the association with occupation and demographic characteristics. Methods: this is a retrospective, observational study conducted in a large university hospital in Milan, Northern Italy. We defined two epidemic waves: 1st (February 2020–July 2020) and 2nd (August 2020–January 2021). Occupational and demographic characteristics of HCWs who underwent nasopharyngeal swabs for SARS-CoV-2 were collected. Results: in the 1st wave, 242 positive subjects (7.2%) were found among 3378 HCWs, whereas in the 2nd wave, the positive subjects were 545 out of 4465 (12.2%). In both epidemic waves positive NPSs were more frequent among HCWs with health-related tasks and lower among students (p < 0.001). However, in the 2nd wave, workers engaged in non-health-related tasks had a peak of 20.7% positivity. Among 160 positive HCWs in the 1st wave who were tested again in the 2nd wave, the rate of reinfection based on SARS-CoV2 RNA cycle quantification value was 0.6%. Conclusions: during the 2nd epidemic wave, we confirmed a significant impact of COVID-19 among HCWs. The rise of infection rate among HCWs seems to reflect the increasing spread of SARS-CoV-2 among the overall population.

show abstract

“…Hence, it is imperative to investigate the association between the antibody response, its duration, and the type of symptoms. We previously showed that an anti-SARS-CoV-2 serological analysis allowed us to follow the diffusion of the virus within healthcare facilities in areas differently hit by the virus 10 . At 8–10 months of distance, we analyzed the duration of this antibody response and evaluated whether there were features correlating with maintenance, reduction, or increase of the antibody response.…”

Section: Introductionmentioning

confidence: 99%

The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Persistence of antibodies to SARS-CoV-2 viral infection may depend on several factors and may be related to the severity of disease or to the different symptoms. Methods We evaluated the antibody response to SARS-CoV-2 in personnel from 9 healthcare facilities and an international medical school and its association with individuals’ characteristics and COVID-19 symptoms in an observational cohort study. We enrolled 4735 subjects (corresponding to 80% of all personnel) for three time points over a period of 8–10 months. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach. Results Here we show in individuals positive for IgG (≥12 AU/mL) at the beginning of the study an increase [p = 0.0002] in antibody response in paucisymptomatic or symptomatic subjects, particularly with loss of taste or smell (anosmia/dysgeusia: OR 2.75, 95% CI 1.753 – 4.301), in a multivariate logistic regression analysis in the first three months. The antibody response persists for at least 8–10 months. Conclusions SARS-CoV-2 infection induces a long lasting antibody response that increases in the first months, particularly in individuals with anosmia/dysgeusia. This may be linked to the lingering of SARS-CoV-2 in the olfactory bulb.

show abstract

SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy

Cited by 22 publications

References 45 publications

Update Alert 10: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

Update Alert 10: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

Nasopharyngeal Testing among Healthcare Workers (HCWs) of a Large University Hospital in Milan, Italy during Two Epidemic Waves of COVID-19

The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients

Contact Info

Product

Resources

About