SARS-CoV-2 virus label-free electrochemical nanohybrid MIP-aptasensor based on Ni3(BTC)2 MOF as a high-performance surface substrate

A label-free fluorescent aptasensor based on the AIE effect and CoOOH for ultrasensitive determination of carcinoembryonic antigen

“…The absorption band at 1630.2 cm −1 corresponds to the absorption peak of the Co–O double bond in the crystal structure, whereas the absorption band at 591.9 cm −1 is related to the absorption peak of Co–O. 2–30…”

Non-autofluorescence Detection of H5N1 Virus Using Photochemical Aptamer Sensors Based on Persistent Luminescent Nanoparticles

“…A simple and effective strategy to potentially solve this problem is a double recognition strategy involving MIP and aptamer. Roushani et al, in particular, have advanced this field and used such a strategy to detect small molecules, proteins, and viruses. − For example, a nanohybrid probe was constructed based on double recognition by an aptamer-based MIP grafted onto a multiwalled carbon nanotubes-chitosan nanocomposites; when this probe was used to detect the core antigen of hepatitis C virus, it reached an impressive detection limit of 1.67 fg mL –1 . Similarly, an artificial receptor biosensor for the recognition of ultratrace trypsin was designed using a hybrid method including both MIP and aptamer technologies.…”

“…By introducing aptamer strings and MIP, a dual-recognition biosensor was also constructed to selectively detect intact SARS-CoV-2 virus. This sensor was found to exhibit a higher selectivity than single-element sensors …”

“…This sensor was found to exhibit a higher selectivity than single-element sensors. 29 In the present study, a viral MIP luminescence sensor based on aptamer-functionalized PLNPs was designed. This probe can rapidly detect H5N1 virus in complex biological samples with high specificity and high sensitivity and with no detectable autofluorescence.…”

Atomically dispersed Mn boosting photoelectrochemical SARS-CoV-2 spike protein immunosensing on carbon nitride

“…In general, the selection of the recognition element in immunoassays is also critical. The use of S protein-derived peptides, antibodies, and amino-aptamers as recognition elements to detect the S protein of SARS-CoV-2 has been reported, but there are few reports on the use of nanobodies (Nb) [12] , [13] , [14] .…”