Sars-cov-2leader-rna-primed transcription and rna-splicing prevention, control and treatment

Farhana, Nikhat; Ansari, Thouheed; Ansari, Moid

doi:10.5958/0974-4150.2020.00057.7

Cited by 6 publications

(1 citation statement)

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“…In the form of intravenous pulse methylprednisolone (MP), systemic corticosteroids were given to some patients with SARS-CoV infection for several reasons [ 174 ]. First, it was hypothesized that the clinical progression of pneumonia and respiratory failure associated with the peak viral load of SARS-CoV may be mediated by the host inflammatory response [ 175 ]. Treatment with systemic corticosteroid blocking agents considerably reduced MCP-1, IL-8, and IP-10 levels 5–8 days after treatment in twenty adults with SARS-CoV infection.…”

Section: Medical Interventions: Antiviral Therapies and Vaccinesmentioning

confidence: 99%

Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting

Elkhatib

Abdelkareem

Khalaf

et al. 2022

Virol J

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The rise of the highly lethal severe acute respiratory syndrome-2 (SARS-2) as corona virus 2019 (COVID-19) reminded us of the history of other pandemics that happened in the last century (Spanish flu) and stayed in the current century, which include Severe-Acute-Respiratory-Syndrome (SARS), Middle-East-Respiratory-Syndrome (MERS), Corona Virus 2019 (COVID-19). We review in this report the newest findings and data on the origin of pandemic respiratory viral diseases, reservoirs, and transmission modes. We analyzed viral adaption needed for host switch and determinants of pathogenicity, causative factors of pandemic viruses, and symptoms and clinical manifestations. After that, we concluded the host factors associated with pandemics morbidity and mortality (immune responses and immunopathology, ages, and effect of pandemics on pregnancy). Additionally, we focused on the burdens of COVID-19, non-pharmaceutical interventions (quarantine, mass gatherings, facemasks, and hygiene), and medical interventions (antiviral therapies and vaccines). Finally, we investigated the nanotechnology between COVID-19 analysis and immune system boosting (Nanoparticles (NPs), antimicrobial NPs as antivirals and immune cytokines). This review presents insights about using nanomaterials to treat COVID-19, improve the bioavailability of the abused drugs, diminish their toxicity, and improve their performance. Graphical Abstract

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Section: Medical Interventions: Antiviral Therapies and Vaccinesmentioning

confidence: 99%

Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting

Elkhatib

Abdelkareem

Khalaf

et al. 2022

Virol J

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The Effects of the Russian Vaccine (Sputnik V) on the Volunteers

Dawood¹

2021

Apollo Medicine

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In silico screening of FDA approved drugs predicts the therapeutic potentials of Antibiotic drugs against the papain like protease of SARS-CoV-2

Kumar¹

2021

RJPT

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Since the outbreak of severe acute respiratory syndrome corona Virus -2 (SARS-CoV-2) has happened in December 2019 in Wuhan, China, the cases of novel coronavirus disease (COVID-19) is rapidly increasing worldwide. In the absence of specific drugs against COVID-19, the fast and reliable choice would be repurposing of existing drugs. Here, we have chosen one of the crucial enzymes of the SARS-CoV-2, Papain like protease (PLpro) and its mutant C111S for the structure-based in-silico screening of the FDA approved drugs. Firstly, the alignment of the wild type and mutant PLpro was done, and no significant change in the global structure was observed. Then based on the docking study, we have reported the best 3 compounds against a mutant and wild type PLpro. These lead compounds include amikacin and mafenide, which are well-known antibiotics. The binding affinity, as well as number of polar and non-polar interactions, indicates their potential against the PLpro. This computational study strongly suggests the experimental validations of the predicted compounds for a confident claim.

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Sars-cov-2leader-rna-primed transcription and rna-splicing prevention, control and treatment

Cited by 6 publications

References 0 publications

Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting

Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting

The Effects of the Russian Vaccine (Sputnik V) on the Volunteers

In silico screening of FDA approved drugs predicts the therapeutic potentials of Antibiotic drugs against the papain like protease of SARS-CoV-2

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