SARSCOVIDB—A New Platform for the Analysis of the Molecular Impact of SARS-CoV-2 Viral Infection

Abstract

The COVID-19 pandemic caused by the new coronavirus (SARS-CoV-2) has become a global emergency issue for public health. This threat has led to an acceleration in related research and, consequently, an unprecedented volume of clinical and experimental data that include changes in gene expression resulting from infection. The SARS-CoV-2 infection database (SARSCOVIDB: ) was created to mitigate the difficulties related to this scenario. The SARSCOVIDB is an online platform that aims to integrate all differential gene expression data, at messenger RNA and protein levels, helping to speed up analysis and research on the molecular impact of COVID-19. The database can be searched from different experimental perspectives and presents all related information from published data, such as viral strains, hosts, methodological approaches (proteomics or transcriptomics), genes/proteins, and samples (clinical or experimental). All information was taken from 24 articles related to analyses of differential gene expression out of 5,554 COVID-19/SARS-CoV-2-related articles published so far. The database features 12,535 genes whose expression has been identified as altered due to SARS-CoV-2 infection. Thus, the SARSCOVIDB is a new resource to support the health workers and the scientific community in understanding the pathogenesis and molecular impact caused by SARS-CoV-2.

Databases, DrugBank, and virtual screening platforms for therapeutic development

“…The database was firstly designed by searching the exact terms “COVID” and “SARS-CoV-2,” with a manual doublecheck for “differential expression of genes or proteins after SARS-CoV-2 infection,” regardless of the host. The SARSCOVIDB contains differential gene expression measurements, at mRNA and protein levels ( da Rosa et al, 2021 ).…”

“… DOI: direct link to the original reference where the data came from. The type of sample indicates if the data were generated using clinical or experimental samples ( da Rosa et al, 2021 ). …”

“…The type of sample indicates if the data were generated using clinical or experimental samples ( da Rosa et al, 2021 ).…”

Association between molecular markers of COVID‐19 and Alzheimer's disease

“…All genes described in this Letter are available at SARSCOVIDB database (https://sarscovidb.org/). 14 André Quincozes-Santos 1,2 Rafael L. da Rosa 3…”

“…I G U R E 1 Alzheimer's disease (AD)-related markers in COVID-19 patients' blood samples. (A) Interactome of known and predicted proteinprotein and gene-disease interactions of upregulated (red circle) and downregulated (green circle) gene-products differentially expressed in blood samples of COVID-19 patients found in SARSCOVIDB database14 and limited to AD-related genes according to DisGeNET, visualized with Cytoscape v3.8.2 (cytoscape.org). (B) DisGeNET association type ontology of identified genes in "A" with AD.…”