SAT-195-The novel HBx mutation F30V correlates with HCC in vivo, hampers HBV replicative efficiency and enhances anti-apoptotic activity of HBx N-terminus in vitro

Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression

“…Epidemiological and experimental studies have pointed out that the development of HCC may be caused and promoted by hepatitis B virus (HBV) and hepatitis C virus infection (HCV), 4 smoking, alcohol, 5 etc In recent years, many people have studied HCC from a genetic perspective and have achieved some results. For example, Salpini R et al demonstrated the novel HBx mutation F30V reduces HBV replication ability, increases the anti‐apoptotic ability of HBx N‐terminus in vitro and associates with HCC in vivo 6 . Zhang et al confirmed reducing of exosome transmitted miR‐320a from cancer‐associated fibroblasts promotes HCC metastasis and proliferation 7 .…”

“…For example, Salpini R et al demonstrated the novel HBx mutation F30V reduces HBV replication ability, increases the anti-apoptotic ability of HBx N-terminus in vitro and associates with HCC in vivo. 6 Zhang et al confirmed reducing of exosome transmitted miR-320a from cancer-associated fibroblasts promotes HCC metastasis and proliferation. 7 But these findings have not yet fully revealed the pathogenesis of HCC, thereby it has important clinical value to further research the occurrence and development of HCC from the epigenetic perspective.…”

Advances on molecular mechanism of hepatitis B virus-induced hepatocellular carcinoma

“…胞周期抑制物，增强 S 期激酶相关蛋白的表达，缩 短细胞增殖周期，从而促使 HCC 的发生 [28] 。 2.3 HBV X 区基因突变 HBV X 区是 HBV 基因组中最小的开放阅读 框，HBV X 区基因编码的 HBx 蛋白与肝细胞的恶 性转化密切相关 [29] 。流行病学研究发现， HBx 突 变可增加 HCC 发生的风险 [30] 。其中，羧基端缺…”