Satellite glial cells: more than just ‘rings around the neuron’

Hanani, Menachem

doi:10.1017/s1740925x10000104

Cited by 39 publications

(35 citation statements)

References 13 publications

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“…It has been demonstrated in cell cultures that membrane-bound genetic calcium indicators can have superior performance to cytoplasmic dyes (such as OGB1 and Fluo-4, which were used in the present study) in detecting local calcium rises under the membrane (Shigetomi et al, 2010a, Shigetomi et al, 2010b, Shigetomi et al, 2011). Translation of this technology in vivo is under development but is not yet available.…”

Section: Discussionmentioning

confidence: 90%

In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase

et al. 2013

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Calcium-dependent release of vasoactive gliotransmitters is widely assumed to trigger vasodilation associated with rapid increases in neuronal activity. Inconsistent with this hypothesis, intact stimulus-induced vasodilation was observed in inositol 1,4,5-triphosphate (IP3) type-2 receptor (R2) knockout (KO) mice, in which the primary mechanism of astrocytic calcium increase – the release of calcium from intracellular stores following activation of an IP3-dependent pathway – is lacking. Further, our results in wild type (WT) mice indicate that in vivo onset of astrocytic calcium increase in response to sensory stimulus could be considerably delayed relative to the simultaneously measured onset of arteriolar dilation. Delayed calcium increases in WT mice were observed in both astrocytic cell bodies and perivascular endfeet. Thus, astrocytes may not play a role in the initiation of blood flow response, at least not via calcium-dependent mechanisms. Moreover, an increase in astrocytic intracellular calcium was not required for normal vasodilation in the IP3R2-KO animals.

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Section: Discussionmentioning

confidence: 90%

In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase

et al. 2013

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“…However, the present findings revealed that SGCs in mouse JNC to be negative for MHC II. The contrary findings of the SGC population may be caused by the ganglionic- and species-specific differences between mouse and human [29,32]. The exact role of SGCs in JNC under physiological and allergic situations remains to be investigated in future experiments.…”

Section: Discussionmentioning

confidence: 99%

Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia

Rochlitzer

Fischer

et al. 2014

Respir Res

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BackgroundA neuroimmune crosstalk between dendritic cells (DCs) and airway nerves in the lung has recently been reported. However, the presence of DCs in airway sensory ganglia under normal and allergic conditions has not been explored so far. Therefore, this study aims to investigate the localisation, distribution and proliferation of DCs in airway sensory ganglia under allergic airway inflammation.MethodsUsing the house dust mite (HDM) model for allergic airway inflammation BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks. With the help of the immunohistochemistry, vagal jugular-nodose ganglia complex (JNC) sections were analysed regarding their expression of DC-markers (MHC II, CD11c, CD103), the neuronal marker PGP 9.5 and the neuropeptide calcitonin gene-related peptide (CGRP) and glutamine synthetase (GS) as a marker for satellite glia cells (SGCs). To address the original source of DCs in sensory ganglia, a proliferation experiment was also carried in this study.ResultsImmune cells with characteristic DC-phenotype were found to be closely located to SGCs and vagal sensory neurons under physiological conditions. The percentage of DCs in relation to neurons was significantly increased by allergic airway inflammation in comparison to the controls (HDM 51.38 ± 2.38% vs. control 28.16 ± 2.86%, p < 0.001). The present study also demonstrated that DCs were shown to proliferate in jugular-nodose ganglia, however, the proliferation rate of DCs is not significantly changed in the two treated animal groups (proliferating DCs/ total DCs: HDM 0.89 ± 0.38%, vs. control 1.19 ± 0.54%, p = 0.68). Also, increased number of CGRP-positive neurons was found in JNC after allergic sensitisation and challenge (HDM 31.16 ± 5.41% vs. control 7.16 ± 1.53%, p < 0.001).ConclusionThe present findings suggest that DCs may migrate from outside into the ganglia to interact with sensory neurons enhancing or protecting the allergic airway inflammation. The increase of DCs as well as CGRP-positive neurons in airway ganglia by allergic airway inflammation indicate that intraganglionic DCs and neurons expressing CGRP may contribute to the pathogenesis of bronchial asthma. To understand this neuroimmune interaction in allergic airway inflammation further functional experiments should be carried out in future studies.

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“…3 In this context, the glial cells of the central nervous system (CNS), and more recently those of the sensory ganglia, have shown to be important in these mechanisms, as they have the ability to communicate with neurons and modulate its activity. 4,5 In sensory ganglia, particularly in dorsal spinal ganglia (DSG) and trigeminal ganglion (TG), satellite glial cells (SGC) establish a privileged relationship with the surrounding neuronal bodies. 6 Interactions between SGC and neurons and its consequences on neuronal excitability are one of the most recent research focuses on the field of pain, as in the last ten years the number of articles on the role these cells play in neuronal activity has increased significantly.…”

Section: Introductionmentioning

confidence: 99%

Satellite glial cells in sensory ganglia: its role in pain

Costa

Neto

2015

Brazilian Journal of Anesthesiology (English Edition)

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Background and objectives: Satellite glial cells in sensory ganglia are a recent subject of research in the field of pain and a possible therapeutic target in the future. Therefore, the aim of this study was to summarize some of the important physiological and morphological characteristics of these cells and gather the most relevant scientific evidence about its possible role in the development of chronic pain. Content: In the sensory ganglia, each neuronal body is surrounded by satellite glial cells forming distinct functional units. This close relationship enables bidirectional communication via a paracrine signaling between those two cell types. There is a growing body of evidence that glial satellite cells undergo structural and biochemical changes after nerve injury, which influence neuronal excitability and consequently the development and/or maintenance of pain in different animal models of chronic pain. Conclusions: Satellite glial cells are important in the establishment of physiological pain, in addition to being a potential target for the development of new pain treatments.Células gliais satélite; Gânglio sensitivo; Dor; Células gliais satélite de gânglios sensitivos: o seu papel na dorResumo Justificativa e objetivos: As células gliais satélite de gânglios sensitivos são um objeto recente de pesquisa na área da dor e um possível alvo terapêutico no futuro. Assim, este trabalho tem Comunicação intraganglionar; Receptores purinérgicos como objetivo resumir algumas das características morfológicas e fisiológicas mais importantes destas células e reunir as evidências científicas mais relevantes acerca do seu possível papel no desenvolvimento da dor crônica. Conteúdo: Nos gânglios sensitivos cada corpo neuronial é envolvido por células gliais satélite, formando unidades funcionais distintas. Esta íntima relação possibilita a comunicação bidirecional, através de uma sinalização parácrina, entre estes dois tipos de células. Existe um número crescente de evidências de que as células gliais satélite sofrem alterações estruturais e bioquímicas, após lesão nervosa, que influenciam a excitabilidade neuronial e consequentemente o desenvolvimento e/ou manutenção da dor, em diferentes modelos animais de dor crônica. Conclusões: As células gliais satélite são importantes no estabelecimento da dor não fisiológica e constituem um alvo potencial para o desenvolvimento de novos tratamentos da dor.

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Satellite glial cells: more than just ‘rings around the neuron’

Cited by 39 publications

References 13 publications

In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase

In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase

Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia

Satellite glial cells in sensory ganglia: its role in pain

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Satellite glial cells: more than just ‘rings around the neuron’

Cited by 39 publications

References 13 publications

In vivoStimulus-Induced Vasodilation Occurs without IP3Receptor Activation and May Precede Astrocytic Calcium Increase

In vivoStimulus-Induced Vasodilation Occurs without IP3Receptor Activation and May Precede Astrocytic Calcium Increase

Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia

Satellite glial cells in sensory ganglia: its role in pain

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Product

Resources

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In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase

In vivoStimulus-Induced Vasodilation Occurs without IP₃Receptor Activation and May Precede Astrocytic Calcium Increase