Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Mazumder, Rana; Mahanti, Beduin; Majumdar, Subhabrota; Pal, Rabindranath; Pahari, Nilanjan

doi:10.1186/s43088-022-00333-w

Cited by 7 publications

(1 citation statement)

References 38 publications

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“…Samples were centrifuged for 10 minutes at 5500 rpm. Blood plasma was preserved and collected at 20 0 C [Mazumder et al 2022]. Mix 0.1 ml of blood with 0.5 ml of acetonitrile to extract the drug and let it sit for 10 minutes.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

Majumdar¹,

Mondal²,

Bose³

et al. 2023

Preprint

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Background Mesoporous silica-loaded docetaxel trihydrate nanoparticles are the potential to target drug delivery toward a specific region with high stability and predictable release at the target region. They have large surface areas and mesoporous structures with large pore volumes, leading to high bioavailability and therapeutic efficacy at the disease site. This study demonstrates how nanoparticles can be prepared using an emulsion technique. Results The ratios of eudragit S100 to eudragit L100 polymers, along with phosphatidylcholine, were varied according to the response surface methodology. DSC and FTIR studies showed that mesoporous silica particles were successful. All formulations had average particle sizes ranging from 70.65 to 143.01nm, with a range of zeta potential from 17.6 ± 026 to 21 ± 011. In-vitro drug delivery studies were achieved for all formulations with a zeta potential of 17.6 ± 026 to 21 ± 011. After oral administration of the docetaxel, plasma levels were measured in vivo bioavailability testing of docetaxel. Docetaxel nanosuspension had a significantly higher Cmax amount than docetaxel micro-suspension (98.03 ± 23.40 ng/ml and 213.67 ± 72.21 ng/ml, respectively, with tmax 45 minutes). Docetaxel was more bioavailable in nanosuspension formulations, according to a bioavailability test of rats. Conclusion The results suggested that the mesoporous silica could be a great potential nanocarrier in colonic delivery with optimal drug content and controlled release docetaxel trihydrate.

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Section: Pharmacokineticsmentioning

confidence: 99%

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

Majumdar¹,

Mondal²,

Bose³

et al. 2023

Preprint

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Exploring the phytochemicals and in-vitro anticancer activities of Torenia crustacea

Nath,

Das,

Ghose

et al. 2024

Discov. Plants

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Recent advances in herbal medicine have given it a unique place within society. This is perhaps due to its less harmful effects and plant-based products' use. The plants that we now call herbal remedies were used for centuries by many communities who relied on their traditional healers. The current study examines the phytochemicals and in-vitro anticancer activities properties of the Torenia crustacea after it have been extracted using various solvents. The plant was collected and authenticated, followed by drying, grinding and extraction using liquids with increasing polarity. The extracts obtained were subjected to phytochemical screening and TLC. The results were interpreted and used as a basis for the in vitro antioxidant and anticancer activities. The presence of phytoconstituents was further proved by TLC analysis, during which it was seen that the acetone extract exhibited two spots on the TLC plate, and the chloroform extract exhibited seven spots on the TLC plate. Various identification tests showed the presence of flavonoids, cardiac glycosides and anthraquinone glycosides. This was used as a basis for the in vitro studies, including antioxidant and anticancer studies. The results suggest that the plant under research exhibits promising in vitro antioxidant activity compared to the standard ascorbic acid with a low IC50 value. The in vitro anticancer experiments also yielded good findings, indicating that this plant has the potential to be used as a strong anticancer agent.

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Polysaccharides gums in drug delivery systems: A review

Putro,

Soetaredjo,

Lunardi

et al. 2023

International Journal of Biological Macromolecules

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Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Cited by 7 publications

References 38 publications

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

Exploring the phytochemicals and in-vitro anticancer activities of Torenia crustacea

Polysaccharides gums in drug delivery systems: A review

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