Saussurea costus extract as bio mediator in synthesis iron oxide nanoparticles (IONPs) and their antimicrobial ability

Abstract

Saussurea costus is from medicinal plants and have therapeutic properties that were recorded in a variety of medical functions. The usage of biomaterials in the synthesis of nanoparticles is an essential strategy in green nanotechnology. Iron oxide nanoparticles (IONPs) were composed in the stage of (2:1, FeCl2: FeCl3) solution by using the aqueous extract of Saussurea costus peel in an eco-friendly method to evaluate their antimicrobial property. The properties of the obtained IONPs were evaluated using a scanning (SEM) and transmission (TEM) electron microscope. The mean size of IONPs discovered by Zetasizer varies between 100 and 300 nm, with a mean particle size of 295 nm. The morphology of IONPs (γ-Fe2O3) was determined to be nearly spherical and prismatic-curved. Moreover, the antimicrobial property of IONPs was assessed with nine pathogenic microbes, revealing that the nanoparticles have antimicrobial activities with Pseudomonas aeruginosa, Escherichia coli, Shigella sp., Staphylococcus sp. and Aspergillus niger, with possible applications in the therapeutic and biomedical fields.

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The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

“…Among the nanosize materials, iron oxide nanoparticles (IONPs) are promising nanoparticles having unique and tunable magnetic properties, excellent biocompatibility, and vast surface to conjugate theranostic moieties. , IONPs are utilized for magnetic resonance imaging (MRI) contrast dyes, drug delivery vehicles, antimicrobial agents, separating environmental pollutants, , and sensing and diagnosing disease or pathogens . Interestingly, the conjugation of antibiotics or other antimicrobial agents with IONPs makes them more sensitive to bacteria and help to overcome drug resistance .…”

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“…Compared to the synthesis of antibiotics, the preparation of antimicrobial nanoparticles is less complex (Al-Awsi et al, 2023). Biogenic IONps were tested against pathogenic microorganisms such as P. aeruginosa, Escherichia coli, Shigella sp., Staphylococcus sp., and Aspergillus niger to determine their antimicrobial properties and estimate their potential for use in the biomedical and therapeutic domains (Al-Brahim, 2023). Synergistic solutions can be prepared for future use as nanomedical therapy as well as chemotherapeutic or preventive agents against pathogens.…”