Saussurea involucrata: A review of the botany, phytochemistry and ethnopharmacology of a rare traditional herbal medicine

Chik, Wai-I; Zhu, Lin; Fan, Lan-Lan; Yi, Tao; Zhu, Guo‐Yuan; Gou, Xiao-Jun; Tang, Yiqun; Xu, Jun; Yeung, Wing-Ping; Zhao, Zhongzhen; Yu, Zhi‐Ling; Chen, Hubiao

doi:10.1016/j.jep.2015.06.033

Cited by 85 publications

(65 citation statements)

References 65 publications

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“…Traditional Chinese medicine helps to delay aging by increasing the antioxidant capacity, enhancing immunity, and regulating the blood lipid concentrations [8, 9]. Additionally, it have produced good clinical efficacy, with little toxicity and few side effects.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway

Wang

Hui

Yao

et al. 2016

BMC Complement Altern Med

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BackgroundPolygonum multiflorum has important effects on anti-aging and immunity enhancement. Many traditional Chinese medicine preparations based on Polygonum multiflorum are widely used for the clinical prevention and treatment of aging. However the mechanisms of these herb mixtures are often unknown. This study investigates the effect of Heshouwuyin, a Chinese herbal compound for invigorating the kidney, on the regulation of testicular cells apoptosis in aging rats.MethodsIn this study, 18-month-old Wistar rats served as a model of natural aging and 12-month-old rats served as a young control group. Heshouwuyin group 1 and group 2 were comprised 18-month-old rats given Heshouwuyin intragastrically for 60 days and 30 days respectively. Then testes of the young control group were isolated in the age of 12 months, the other three groups were in the age of 18 months.ResultsTUNEL assay showed that the rate of testicular cell apoptosis was obviously higher and Flow cytometry analysis showed that the rate of cell proliferation was significantly lower in the natural aging group than in the young control group and that intervention with Heshouwuyin could reverse this phenomenon. Therefore, we further applied microarray analysis to screen out differentially expressed genes regulated by Heshouwuyin and related to cell apoptosis. The expression of these genes was observed by quantitative fluorescence PCR, immunofluorescence staining, and western blot. The results showed that the expression of 14-3-3σ was significantly lower and that the expression of DR6, BAX, caspase-3 and Cytc were significantly higher in the natural aging group than in the young control group, but intervention with Heshouwuyin significantly reversed this phenomenon. Moreover, the curative efficacy of Heshouwuyin after 60 days was better than that of Heshouwuyin after 30 days.ConclusionOur study suggests that Heshouwuyin has anti-aging effects on the testis by means of inhibiting the occurrence of apoptosis in spermatogenic cells, thus improving the spermatogenic function of the testis. This is mainly achieved by regulating the expression of key genes in the mitochondrial apoptosis pathway.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway

Wang

Hui

Yao

et al. 2016

BMC Complement Altern Med

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“…This study must be interpreted in context of certain limitations. As compound prescription is one of the key characteristics of TCM, the combined use of TCM injections with other medicine may change the therapeutic effects as well as adverse effects . As reports with multidrug therapies were excluded from the study, the results might not reflect the safety features of TCM injections under the circumstances of multidrug therapies.…”

Section: Discussionmentioning

confidence: 99%

Safety profile of traditional Chinese herbal injection: An analysis of a spontaneous reporting system in China

Deng

et al. 2019

Pharmacoepidemiology and Drug

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Purpose Although a series of serious adverse events have continually raised concerns about the potential toxicity of traditional Chinese medicine injections (TCM injections), studies on this subject are still sparse. We conducted a descriptive analysis of a spontaneous reporting system in China to describe the safety profile of TCM injections. Methods The safety profile of TCM injections is described by descriptive analysis of 559 066 adverse reports collected from Guangdong Provincial Center for adverse drug reaction (ADR) Monitoring in China during 2003 to 2017. Results The percentage of new or serious ADRs of TCM injections is much higher than average percentage of China's spontaneous reporting system (SRS) as a whole (48.70% vs <25%). Compared with conventional injections, TCM injections have a slightly lower percentage of serious ADRs (6.02% vs 6.72%) and much higher percentage of unknown (new) ADRs (46.74% vs 24.13%). The gender and age distribution for TCM injections are similar to conventional injections. The reporting rates of ADRs increased with age. Anaphylactic shock and anaphylactoid reaction are high‐risk ADRs for TCM injections and, anaphylactic shock is ranked number 1 in causing deaths (50.00%). Conclusions There are some differences and similarities on the safety profile between TCM injections and conventional injections. TCM injections have higher risk of adverse effects than any other dosage forms of TCM medications and higher percentage of new or serious adverse effects than conventional injections. A lot of work need to be done to clarify the huge amount of potential unknown adverse effects related to TCM injections.

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“…Saussureae involucratae Flos has been widely applied as a clinical treatment for thousands of years (26). The jiangu capsule is composed of 12 types of natural medicine and has been used to treat a number of conditions, including arthralgia, cold and sore muscles, stiff limbs, inconvenient flexion and activity limitation caused by osteoarthritis (27,28).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the acute and chronic toxicity of the jiangu capsules

et al. 2017

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Abstract. Saussureae involucratae Flos is the primary component of the jiangu capsule, which also consists of 12 types of natural medicine. It is a traditional Chinese medicine used to treat a number of conditions including arthralgia, cold and sore muscles, stiff limbs, inconvenient flexion and activity limitation caused by different types of osteoarthritis. The present study was performed to assess the safety of the jiangu capsule following acute and chronic administration in mice and rats. In the acute study, mice were treated with the jiangu capsule orally at 16 g/kg/day, the highest dose, for 14 days. In the chronic oral toxicity study, rats were treated with 2, 4 and 8 g/kg/day of the jiangu capsule for 6 months. The general condition, body weight changes, food and water consumption, hematological and biochemical parameters, urinalysis, systematic anatomy and organ weights of the rats were monitored and histopathological examination was performed at the end of 3 and 6 months' daily administration, and following 14 days of withdrawal. There were no signs of toxicity in the general condition and body weight of the mice was not significantly affected by the treatment. Furthermore, necropsy findings for the animals in the acute and chronic toxicity studies demonstrated that no mortalities had occurred. The results of the current study indicate that treatment with the jiangu capsule did not induce mortality or any detectable abnormalities in mice and rats.

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Saussurea involucrata: A review of the botany, phytochemistry and ethnopharmacology of a rare traditional herbal medicine

Cited by 85 publications

References 65 publications

Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway

Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway

Safety profile of traditional Chinese herbal injection: An analysis of a spontaneous reporting system in China

Evaluation of the acute and chronic toxicity of the jiangu capsules

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