Saxitoxins-producing potential of the marine dinoflagellate Alexandrium affine and its environmental implications revealed by toxins and transcriptome profiling

Kim, Hansol; Park, Hyunjun; Wang, Hui; Kim, Tae-Hee; Ki, Jang‐Seu

doi:10.1016/j.marenvres.2023.105874

Cited by 7 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, genes participating in the tailoring, regulation, and transportation of STXs are involved in synthesizing various PST analogs [130][131][132][133]. Similarly, toxic dinoflagellates have sxt gene homologs to cyanobacteria [12,[134][135][136]. Among the genes, sxtA is known to be involved in the initial stage of STX synthesis and is the most widely studied [140].…”

Section: Genetic Understanding Of Environmental Factors and Stxs Bios...mentioning

confidence: 99%

“…Through various molecular studies, sxtA4 was identified in various toxic dinoflagellates, including Alexandrium spp., G. catenatum, and P. bahamense. Furthermore, it was suggested that the presence of sxtA4 and its copy number have a significant relationship with STX synthesis [9,134]. Among the genes, sxtA is known to be involved in the initial stage of STX synthesis and is the most widely studied [140].…”

Section: Genetic Understanding Of Environmental Factors and Stxs Bios...mentioning

confidence: 99%

See 1 more Smart Citation

Environmental Factors Modulate Saxitoxins (STXs) Production in Toxic Dinoflagellate Alexandrium: An Updated Review of STXs and Synthesis Gene Aspects

Bui,

Pradhan,

Kim

et al. 2024

Toxins

Self Cite

View full text Add to dashboard Cite

The marine dinoflagellate Alexandrium is known to form harmful algal blooms (HABs) and produces saxitoxin (STX) and its derivatives (STXs) that cause paralytic shellfish poisoning (PSP) in humans. Cell growth and cellular metabolism are affected by environmental conditions, including nutrients, temperature, light, and the salinity of aquatic systems. Abiotic factors not only engage in photosynthesis, but also modulate the production of toxic secondary metabolites, such as STXs, in dinoflagellates. STXs production is influenced by a variety of abiotic factors; however, the relationship between the regulation of these abiotic variables and STXs accumulation seems not to be consistent, and sometimes it is controversial. Few studies have suggested that abiotic factors may influence toxicity and STXs-biosynthesis gene (sxt) regulation in toxic Alexandrium, particularly in A. catenella, A. minutum, and A. pacificum. Hence, in this review, we focused on STXs production in toxic Alexandrium with respect to the major abiotic factors, such as temperature, salinity, nutrients, and light intensity. This review informs future research on more sxt genes involved in STXs production in relation to the abiotic factors in toxic dinoflagellates.

show abstract

Section: Genetic Understanding Of Environmental Factors and Stxs Bios...mentioning

confidence: 99%

Section: Genetic Understanding Of Environmental Factors and Stxs Bios...mentioning

confidence: 99%

Environmental Factors Modulate Saxitoxins (STXs) Production in Toxic Dinoflagellate Alexandrium: An Updated Review of STXs and Synthesis Gene Aspects

Bui,

Pradhan,

Kim

et al. 2024

Toxins

Self Cite

View full text Add to dashboard Cite

show abstract

Promoter regions of sxtA and sxtG reveal relationship between saxitoxin biosynthesis and photosynthesis in toxic Alexandrium catenella

Kim,

Bui,

Shin

et al. 2024

J Appl Phycol

View full text Add to dashboard Cite

Development of saxitoxin biosynthesis gene sxtB-targeted qPCR assay for the quantification of toxic dinoflagellates Alexandrium catenella (group I) and A. pacificum (group IV) occurring in the Korean coast

Kim,

Park

et al. 2024

Harmful Algae

View full text Add to dashboard Cite

Saxitoxins-producing potential of the marine dinoflagellate Alexandrium affine and its environmental implications revealed by toxins and transcriptome profiling

Cited by 7 publications

References 72 publications

Environmental Factors Modulate Saxitoxins (STXs) Production in Toxic Dinoflagellate Alexandrium: An Updated Review of STXs and Synthesis Gene Aspects

Environmental Factors Modulate Saxitoxins (STXs) Production in Toxic Dinoflagellate Alexandrium: An Updated Review of STXs and Synthesis Gene Aspects

Promoter regions of sxtA and sxtG reveal relationship between saxitoxin biosynthesis and photosynthesis in toxic Alexandrium catenella

Development of saxitoxin biosynthesis gene sxtB-targeted qPCR assay for the quantification of toxic dinoflagellates Alexandrium catenella (group I) and A. pacificum (group IV) occurring in the Korean coast

Contact Info

Product

Resources

About