Scaffold of Selenium Nanovectors and Honey Phytochemicals for Inhibition of Pseudomonas aeruginosa Quorum Sensing and Biofilm Formation

Prateeksha,; Singh, Braj Raj; Shoeb, Mohd; Sharma, Swati; Naqvi, Andleeb Z.; Gupta, Vijai Kumar; Singh, Brahma N.

doi:10.3389/fcimb.2017.00093

Cited by 83 publications

(50 citation statements)

References 58 publications

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“…When P. aeruginosa PAO1 was cultivated in the presence 5 Journal of Nanomaterials of sub-MICs of TONFs, elastase activity was suppressed significantly to 59% and protease production was reduced up to 64% as compared to untreated control (Figure 8). Prateeksha et al [50] reported a comparable decrease in elastase (52%) and protease (60%) after treatment with sub-MICs of selenium nanovectors.…”

Section: Effects Of Tonfs On Quorummentioning

confidence: 94%

Facile Synthesis of Tin Oxide Hollow Nanoflowers Interfering with Quorum Sensing-Regulated Functions and Bacterial Biofilms

Al‐Shabib

Husain

Ahmad

et al. 2018

Journal of Nanomaterials

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Monophasic tin dioxide nanoflowers (TONFs) assembled by rod-like nanostructures were prepared by coprecipitation method using tin chloride and ammonia precipitators, as the starting materials, without using any surfactants or templates. The structural, compositional, optical, and morphological properties of TONFs were investigated by XRD, FT-IR, UV-vis, SEM-EDX, and TEM techniques. Synthesized TONFs demonstrated inhibition of quorum sensing- (QS-) regulated virulence in pathogens, viz., Chromobacterium violaceum, Pseudomonas aeruginosa, and Serratia marcescens. Significant reduction in biofilm formation in all test pathogens was also observed which was further validated by CLSM images illustrating disturbed biofilm architecture. Vital functions like EPS, swarming motility, and cell surface hydrophobicity that contribute to successful biofilm formation were reduced after addition of sub-MICs of TONFs. Significant eradication of preformed biofilms was recorded upon addition of subinhibitory concentrations of TONFs in all test pathogens. The study highlights the broad-spectrum QS and biofilm inhibition by TONFs that can be exploited in future to protect food from contamination and combatting persistent drug-resistant infections.

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Section: Effects Of Tonfs On Quorummentioning

confidence: 94%

Facile Synthesis of Tin Oxide Hollow Nanoflowers Interfering with Quorum Sensing-Regulated Functions and Bacterial Biofilms

Al‐Shabib

Husain

Ahmad

et al. 2018

Journal of Nanomaterials

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“…A delivery system based on varnishes releasing the QSI thiazolidinedione-8 (TZD-8) was used on catheters and were active against Candida albicans biofilms (Shenderovich et al, 2015 ). Notably, honey polyphenols were introduced into a scaffold of selenium nanovectors for quenching P. aeruginosa PAO1 in vitro and in vivo (Prateeksha et al, 2017 ).…”

Section: Use Of Quorum Quenching Molecules In Medical Devicesmentioning

confidence: 99%

Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

et al. 2018

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Numerous bacteria utilize molecular communication systems referred to as quorum sensing (QS) to synchronize the expression of certain genes regulating, among other aspects, the expression of virulence factors and the synthesis of biofilm. To achieve this process, bacteria use signaling molecules, known as autoinducers (AIs), as chemical messengers to share information. Naturally occurring strategies that interfere with bacterial signaling have been extensively studied in recent years, examining their potential to control bacteria. To interfere with QS, bacteria use quorum sensing inhibitors (QSIs) to block the action of AIs and quorum quenching (QQ) enzymes to degrade signaling molecules. Recent studies have shown that these strategies are promising routes to decrease bacterial pathogenicity and decrease biofilms, potentially enhancing bacterial susceptibility to antimicrobial agents including antibiotics and bacteriophages. The efficacy of QSIs and QQ enzymes has been demonstrated in various animal models and are now considered in the development of new medical devices against bacterial infections, including dressings, and catheters for enlarging the therapeutic arsenal against bacteria.

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“…Honey was tested in vitro against aerobic bacteria such as; S. aureus [28]; MRSA [29][30][31]; E. coli [32]; S. typhimurium [33]; Klebsiella pneumonia [34]; Ps. Aerugenosa 35 and anaerobic Porphyromonas gingivalis [36]. Also its antifungal activity against Candida sp.…”

Section: Discussionmentioning

confidence: 99%

Honey and Medicinal Plants in the Management of Certain Surgical Bovine Clow Affections

Ma¹,

As²,

Mm³

et al. 2017

IJCAM

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Owing to the worldwide spread of bacterial antimicrobial resistance, it is of great concern to search for antimicrobial agents of natural origin. Since the antimicrobial activity of honey was widely documented, the study aimed to evaluate its use comparing with certain medicinal plants extracts as surgical dressing of bovine clow affections. Aqueous extracts of Thymus vulgaris (T. vulgaris), Matricaria chamomilla (M. chamomilla) and Origanum vulgare (O. vulgare) were prepared to be used in vitro and in vivo studies in this work. Clinical aerobic or anaerobic bacterial strains were isolated from some clinical surgical bovine clow affections, and were used to determine the minimal inhibitory concentrations (MICs) of the prepared extracts against these pathogens.The study concluded that all tested aerobic bacterial strains were inhibited with 10 % of all tested extracts, while the anaerobic strains were inhibited with 10 % of T. vulgaris and 15 % of both O. vulgare and M. chamomilla extracts. According the achieved MICs values, lotions and ointments of the entended medicinal plants were made to be used during the in vivo study as follow: 20 lactating dairy cows suffering from different surgical clow affections were classified to equal four groups (A -D) which were managed with surgical dressing and received: honey (A): T. vulgaris (B), M. chamomilla: (C) and O. vulgare: (D) extracts with their MICs. All cows of groups A & B (no = 10)as well as one cow from group (C) showed complete healing by the day 30 while, none of group (D).The study concluded that with the alternative medical trends, application of honey -as it is -in surgical dressing of bovine digital dermatitis or inter digital necrobacillosis is the most effective valuable economic tool among the four materials studied for its superurity and feasibility followed by the use of T. vulgaris extract 10% in lotion and ointment preparation.

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Scaffold of Selenium Nanovectors and Honey Phytochemicals for Inhibition of Pseudomonas aeruginosa Quorum Sensing and Biofilm Formation

Cited by 83 publications

References 58 publications

Facile Synthesis of Tin Oxide Hollow Nanoflowers Interfering with Quorum Sensing-Regulated Functions and Bacterial Biofilms

Facile Synthesis of Tin Oxide Hollow Nanoflowers Interfering with Quorum Sensing-Regulated Functions and Bacterial Biofilms

Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

Honey and Medicinal Plants in the Management of Certain Surgical Bovine Clow Affections

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