Scaffolds of PDLLA/bioglass 58S produced via selective laser sintering

Pereira, Rafaela do Vale; Salmoria, Gean Vitor; Moura, Marcela Oliveira Caldeira de; Aragones, Águedo; Fredel, Márcio C.

doi:10.1590/s1516-14392014005000075

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…An alternative sol–gel synthesis of bioactive glass was used when compared with others already reported . Tetraethyl orthosilicate (TEOS) (98%, Sigma–Aldrich, USA), triethyl phosphate (TEP) (99.8%, Sigma–Aldrich, USA) and calcium nitrate tetrahydrate (Ca(NO 3 ) 2 ·4H 2 O) (Vetec, Brazil) were used as precursors of silicon, phosphorous and calcium oxide, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…An alternative sol-gel synthesis of bioactive glass was used when compared with others already reported. 49 Tetraethyl orthosilicate (TEOS) (98%, Sigma-Aldrich, USA), triethyl phosphate (TEP) (99.8%, Sigma-Aldrich, USA) and calcium nitrate tetrahydrate (Ca(NO 3 ) 2 Á4H 2 O) (Vetec, Brazil) were used as precursors of silicon, phosphorous and calcium oxide, respectively. Ethyl alcohol (EtOH, P.A., Synth, Brazil) was used as solvent of TEOS and TEP, and nitric acid (HNO 3 , 68%, Vetec, Brazil) was used to dissolve Ca(N-O 3 ) 2 Á4H 2 O, respecting the "like dissolves like" chemical dissolution rule.…”

Section: Synthesis Of 58s Bioactive Glass Powder Via Sol-gel Processmentioning

confidence: 99%

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Processing and strengthening of 58S bioactive glass‐infiltrated titania scaffolds

Mesquita‐Guimarães

Leite

Souza

et al. 2016

J Biomedical Materials Res

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In this work, TiO ceramic scaffolds were fabricated by the replica method using polyurethane (PU) sponges. Suspensions with high solid content were used to achieve scaffolds with improved mechanical behavior. TiO ceramic suspensions were optimized by rheological studies using different additives. It was found that the composition with 0.5 wt % Darvan enhanced the covering of the sponge struts. PU sponges of 45 to 80 ppi (pore per inch) were well coated without clogging pores. A thermal treatment with varying holding times, temperatures and heating rates was adjusted. The influence of different pore sizes on mechanical strength was evaluated. It was possible to obtain TiO scaffolds with 90% porosity and high pore interconnectivity, having compressive strength exceeding 0.6 MPa. TiO scaffolds were filled up with a 58S bioactive glass suspension to impart bioactive character to the scaffolds. These hybrid structures presented mechanical strengthening of about 26-213% depending on their sponge porosity. The prediction for cells viability via zeta potential measures indicated that this hybrid material is very promising for scaffold application with -19 to -25 mV between pH of 7.35-7.45. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 590-600, 2017.

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of 58s Bioactive Glass Powder Via Sol-gel Processmentioning

confidence: 99%

Processing and strengthening of 58S bioactive glass‐infiltrated titania scaffolds

Mesquita‐Guimarães

Leite

Souza

et al. 2016

J Biomedical Materials Res

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show abstract

“…SBF'de bekletme öncesi ve sonrasında, ağırlıkça %1 bakır nanoparçacıkları içeren yapı iskeleleri için FTIR spektrumu Şekil 4'te verilmiştir. SBF öncesi yapı iskelelerinin 3000 cm -1 ve 2945 cm -1 'de bulunan pikleri, PDLLA'nın metil ve metilen gruplarının gerilmesinden kaynaklanmaktadır [24,25]. PDLLA'nın karakteristik bantlarından biri olan ester karbonil gruplarının gerilme modu (C = O) 1747 cm -1 'de gözükmektedir [24,26].…”

Section: şEkil 3 üRetilen Kompozit Yapı Iskelelerinin Sem Görüntüleriunclassified

“…PDLLA'nın karakteristik bantlarından biri olan ester karbonil gruplarının gerilme modu (C = O) 1747 cm -1 'de gözükmektedir [24,26]. 1452 cm -1 ve 1381 cm -1 'deki pikler sırasıyla CH3 asimetrik ve δs CH3 simetrik deformasyon modlarını göstermektedir [24][25][26]. 1263 cm -1 'de görünen pik, ester gruplarının -CO-O-gerilme bantlarına aittir [25,27].…”

Section: şEkil 3 üRetilen Kompozit Yapı Iskelelerinin Sem Görüntüleriunclassified

“…1452 cm -1 ve 1381 cm -1 'deki pikler sırasıyla CH3 asimetrik ve δs CH3 simetrik deformasyon modlarını göstermektedir [24][25][26]. 1263 cm -1 'de görünen pik, ester gruplarının -CO-O-gerilme bantlarına aittir [25,27]. Bu piklere ek olarak, 1183, 1135, 1082 ve 1043 cm -1 'deki pikler ise = C-O gerilme bantları olduğu belirlenmiştir.…”

Section: şEkil 3 üRetilen Kompozit Yapı Iskelelerinin Sem Görüntüleriunclassified

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Stronsiyum Katkılı Biyocam ve Bakır Nanoparçacıklarından 3D Kompozit Yapı İskelesi Üretimi

Özyuğuran-Arifoğlu

2018

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım Ve Teknoloji

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ÖzBu çalışmada, çözücü döküm ve tanecik uzaklaştırma yöntemi kullanılarak, çok işlevli yapı iskelelerinin geliştirilmesi için ilgili iyonlarla biyoaktif cam (BG) / polimer 3D kompozit yapı iskelelerinin üretilmesi amaçlanmıştır. Gözenekli yapıya sahip yapı iskeleleri başarıyla sentezlenmiş ve yapı iskelelerinin mikroyapısında iyi bir gözenek bağlantısının bulunduğu gözlemlenmiştir. Kompozit yapı iskelelerinin in vitro biyoaktivitesi; Taramalı Elektron Mikroskopisi (SEM), X-ışını kırınımı (XRD) ve Fourier-Dönüşümlü Kızılötesi Spektroskopi (FTIR) ölçümleri ile teyit edilmiştir. Bunun dışında, terapötik iyonların salınımının; SBF (Simulated Body Fluid)'de kalma sürelerinin bir fonksiyonu olarak, stronsiyum ve bakır iyonları için sırasıyla 1.27-5.36 ppm ve 1.53-5.42 ppm aralığında değiştiği belirlenmiştir. Bu sonuç yapı iskelelerinin, kemik dokusu rejenerasyonunun belirleyicisi olan SBF ortamına, stronsiyum ve bakır dozlarının kontrollü olarak verebileceğini göstermiştir. AbstractIn this study, it was aimed to produce BG/polymer 3D composite scaffolds with relevant ions in order to develop multifunctional scaffolds by using salt template-partibakırlate leaching technique. The porous scaffolds were successfully synthesized and it was observed that there was a good pore interconnectivity maintained in the scaffold microstructure. In vitro bioactivity of the composite scaffolds was confirmed by Scanning Electron Microscopy, X-ray diffraction and Fourier-Transform Infrared Spectroscopy measurements. Furthermore, the release of therapeutic ions were determined as a function of immersion time in SBF, which was in the range of 1.27-5.36 ppm and 1.53-5.42 ppm for strontium and copper ions, respectively. This result indicated that the scaffolds can deliver controlled doses of strontium and copper toward the SBF medium that is the determinant for bone tissue regeneration.

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Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing

Canziani¹,

Hanschmann²,

Tischer³

et al. 2022

Adv Funct Materials

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Additive manufacturing, in particular powder bed-based fabrication processes hold promise to revolutionize biomedical engineering for the ability to provide customized, functional implants, for example as bone replacement materials. However, providing functional powder particles that unify material requirements for biodegradable and bioactive biomaterials and process requirements to enable successful powder bed fusion remains an unmet challenge. Here, a supraparticle-based approach to create biodegradable poly(lactic acid) and composite powders for the additive manufacturing of bone replacement materials is introduced. Colloidal binary Ca-SiO 2 glasses and hydroxyapatite are incorporated as bioactive functional additives to support the formation of bone-like calcium phosphate. The supraparticle powders are prepared by a scalable spraydrying process, which offers control of particle size, shape, and composition. All process-relevant powder characteristics are analyzed as a function of composition and structure, including flowability, thermal, and melt rheological properties. The optimized supraparticle powders are successfully used in the process of laser powder bed fusion of polymers to prepare macroscopic specimens via additive manufacturing. It is demonstrated that the material combination of the composites provides relevant functional properties, including biodegradation and bioactivity. The process provides a flexible and adjustable toolbox for the design of functional powders toward biomedical additive manufacturing.

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Scaffolds of PDLLA/bioglass 58S produced via selective laser sintering

Cited by 25 publications

References 22 publications

Processing and strengthening of 58S bioactive glass‐infiltrated titania scaffolds

Processing and strengthening of 58S bioactive glass‐infiltrated titania scaffolds

Stronsiyum Katkılı Biyocam ve Bakır Nanoparçacıklarından 3D Kompozit Yapı İskelesi Üretimi

Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing

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