Scalability of 3D printed structured porous milli-scale reactors

Process intensification of the catalytic hydrogenation of squalene using a Pd/CNT catalyst combining nanoparticles and single atoms in a continuous flow reactor

“…Furthermore, extended or new process windows can be reached beyond the batch to continuous transposition, allowing to expect more process intensification of the synthesis [37,38]. Finally, with the more and more mature "seamless scale up" strategy [39][40][41],…”

Investigations of mixing and heat transfer in a structured tube‐in‐tube millireactor by numerical, experimental and statistical methods

“…special structure design shows excellent potential for application in the chemical industry as they provide efficient heat and mass transfer while significantly enhancing the throughput capacity of a reactor. 18,19 A large number of scholars and companies have used that to scale up: Advanced reactor from Corning, 20,21 Lonza TG Large and Lonza Multi-injection SZ from Ehrfeld Mikrotechnik, 22 Slit Plate reactor from Syrris Ltd, 3D printed porous millireactors by Kuhn et al, 23,24 and various static mixers. [25][26][27][28] Compared to other complex and expensive flow reactors, the tube-in-tube millireactor can be easily assembled using off-the-shelf commercially available components, which is effortlessly machinable, and is free to select tube materials on demand.…”

“…Despite all these advantages of transfer intensification in microchemical devices, one of their major challenges is that economic production lacks sufficient throughput to meet industrial needs 17 . The strategy of extending the characteristic size to millimeters and compensating for the effects of sizing up on the mixing and transfer by a special structure design shows excellent potential for application in the chemical industry as they provide efficient heat and mass transfer while significantly enhancing the throughput capacity of a reactor 18,19 . A large number of scholars and companies have used that to scale up: Advanced reactor from Corning, 20,21 Lonza TG Large and Lonza Multi‐injection SZ from Ehrfeld Mikrotechnik, 22 Slit Plate reactor from Syrris Ltd, 3D printed porous millireactors by Kuhn et al, 23,24 and various static mixers 25–28 …”

Gas–Liquid Taylor Flow Characteristics in a Fractal Microchannel Network during Numbering-up and Sizing-up

“…By comparing the top and bottom halves of the bubble on the vertical plane passing through the channel axis, the authors observed obvious bubble asymmetry. To date, though both academic and industrial communities are endeavoring to scale-up microreactors to the milliscale, the dependence of fluid dynamics on the characteristic dimension is still not very clear. − Comparing with the liquid–liquid flow, the reported studies related to the size effect in gas–liquid flow seem not deep enough.…”