Scalable and robust photochemical flow process towards small spherical gold nanoparticles

Bianchi, Pauline; Petit, Guillaume; Monbaliu, Jean‐Christophe M.

doi:10.1039/d0re00092b

Cited by 24 publications

(20 citation statements)

References 74 publications

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“…Corning's Advanced‐Flow G3 photoreactor, depicted in Figure 2B, has recently been utilized for the photochemical synthesis of Au nanoparticles at production scale (≈360 L of aqueous Au nanoparticles a day), providing an alternative to high‐temperature reduction reactions. [ 71,72 ]…”

Section: Colloidal Nanomaterials Synthesis: Batch Versus Flowmentioning

confidence: 99%

“…Corning's Advanced-Flow G3 photoreactor, depicted in Figure 2B, has recently been utilized for the photochemical synthesis of Au nanoparticles at production scale (≈360 L of aqueous Au nanoparticles a day), providing an alternative to high-temperature reduction reactions. [71,72] Despite the advantages of microfabricated reactors, advanced high-resolution fabrication techniques can pose a notable barrier to inexperienced users as they often entail precise etching, thermoforming, or channel casting. In addition, current chip-based designs inhibit reconfiguration, making reactor prototyping and design exploration labor and cost-intensive endeavors.…”

Section: Microreactor Design For Controlled Nanomaterials Synthesismentioning

confidence: 99%

“…Adapted with permission. [71] Copyright 2020, Royal Society of Chemistry. C) FEP tube-based flow reactor incorporating an FEP tube braided (static) micromixer and commercially available fluidic junctions, from Epps et al Adapted with permission.…”

Section: Microreactor Design For Controlled Nanomaterials Synthesismentioning

confidence: 99%

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Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

2020

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Solution-processed organic, [1-3] metallic, [4-6] and semiconductor [7,8] nanomaterials, possess unique size-related physicochemical, optical, magnetic, and electronic properties. These materials have enabled groundbreaking advancements in a variety of applications including catalysis, [9-11] drug delivery, [12,13] data storage, [14] and solar cells. [15] Different nucleation and growth models such as LaMer burst nucleation, [16] Ostwald ripening, [17] Finke-Watzky two-step mechanism, [18] orientated attachment, [19] and coalescence [20] have attempted to explain the mechanisms through which nanoparticles are formed in In recent years, microfluidic technologies have emerged as a powerful approach for the advanced synthesis and rapid optimization of various solution-processed nanomaterials, including semiconductor quantum dots and nanoplatelets, and metal plasmonic and reticular framework nanoparticles. These fluidic systems offer access to previously unattainable measurements and synthesis conditions at unparalleled efficiencies and sampling rates. Despite these advantages, microfluidic systems have yet to be extensively adopted by the colloidal nanomaterial community. To help bridge the gap, this progress report details the basic principles of microfluidic reactor design and performance, as well as the current state of online diagnostics and autonomous robotic experimentation strategies, toward the size, shape, and composition-controlled synthesis of various colloidal nanomaterials. By discussing the application of fluidic platforms in recent high-priority colloidal nanomaterial studies and their potential for integration with rapidly emerging artificial intelligence-based decision-making strategies, this report seeks to encourage interdisciplinary collaborations between microfluidic reactor engineers and colloidal nanomaterial chemists. Full convergence of these two research efforts offers significantly expedited and enhanced nanomaterial discovery, optimization, and manufacturing.

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Section: Colloidal Nanomaterials Synthesis: Batch Versus Flowmentioning

confidence: 99%

Section: Microreactor Design For Controlled Nanomaterials Synthesismentioning

confidence: 99%

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Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

2020

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“…Several large-scale photoreactions in flow have been described in the past few years, mostly based on specific reactor designs. 16 Recently, the HANU reactor, a multipurpose continuous-flow photoreactor developed by Creaflow, 17 was utilized for the multigram-scale synthesis of an N -arylpyrrolidine derivative via a heterogeneous Ni/photoredox dual-catalyzed C–N coupling. 18 This milli-structured photoreactor combines an oscillatory flow regime and static mixing elements along a narrow channel, ensuring good irradiation and mixing properties ( Scheme 1 ).…”

Section: Introductionmentioning

confidence: 99%

Optimization of a Decatungstate-Catalyzed C(sp³)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

Wen

Maheshwari

Sambiagio

et al. 2020

Org. Process Res. Dev.

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Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C–H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp 3 )–H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.

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“…15 However, reactor fouling remains a serious problem with ow-based nanoparticle synthesis. Tightly controlled conditions containing alkali metals can alleviate fouling, 16 but use of other metals leads to nanoparticle contamination and their implementation in a commercial photoreactor can be prohibitively expensive.…”

Section: Introductionmentioning

confidence: 99%

A Low Cost & Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles

Ross

Muñoz

Rotstein

et al. 2020

Preprint

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Rapid synthesis of nanomaterials in scalable quantities is critical for accelerating discovery and commercial translation of nanoscale-based technologies. The synthesis of metal nanogold and silver in volumes larger than 100 mL is not automatized and might require of the use of harsh conditions that in most cases is detrimental for the production of nanoparticles with reproducible size distribution. In this work, we present the development and optimization of an open access low-cost NanoParticle Flow Synthesis System (NPFloSS) that allows for the rapid preparation of volumes of up to 1L of gold and silver nanoparticle aqueous solutions.

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Scalable and robust photochemical flow process towards small spherical gold nanoparticles

Abstract: Scalable preparation of small spherical gold nanoparticles under photochemical flow conditions.

Cited by 24 publications

References 74 publications

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

Optimization of a Decatungstate-Catalyzed C(sp³)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

A Low Cost & Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles

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Scalable and robust photochemical flow process towards small spherical gold nanoparticles

Abstract: Scalable preparation of small spherical gold nanoparticles under photochemical flow conditions.

Cited by 24 publications

References 74 publications

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

A Low Cost &amp; Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles

Contact Info

Product

Resources

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Optimization of a Decatungstate-Catalyzed C(sp³)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

A Low Cost & Open Access System for Rapid Synthesis of Large Volumes of Gold and Silver Nanoparticles